Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
326 KP13_31813 hypothetical protein AlphaFold + ColabFold – – 0.397 No Hit 0.0% —
327 KP13_31811 hypothetical protein ColabFold – – 0.001 No Hit 0.0% —
328 KP13_31808 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase AlphaFold + ColabFold
2.1.1.14
GO:0008270Binding to a zinc ion (Zn). GO:0003871Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +36 total
0.894 No Hit 0.0% —
329 KP13_31807 Copper resistance protein C AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0006825The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005507Binding to a copper (Cu) ion. +25 total
0.315 No Hit 0.0% —
330 KP13_31806 Type VI secretion system protein AlphaFold + ColabFold – – 0.74 No Hit 0.0% —
331 KP13_31804 ASCH family protein AlphaFold + ColabFold – – 0.655 No Hit 0.0% —
332 KP13_31802 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.414 No Hit 0.0% —
333 KP13_31801 putative oxidative stress defense protein AlphaFold + ColabFold – – 0.494 No Hit 0.0% —
334 KP13_31797 hypothetical protein AlphaFold + ColabFold – – 0.565 No Hit 0.0% —
335 KP13_31795 hypothetical protein AlphaFold + ColabFold – – 0.082 No Hit 0.0% —
336 KP13_31793 hypothetical protein ColabFold – – 0.238 No Hit 0.0% —
337 KP13_31792 transposase for insertion sequence element IS1328 ColabFold –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.869 No Hit 0.0% —
338 KP13_31791 RNA polymerase sigma factor RpoD rpoD AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.769 No Hit 0.0% —
339 KP13_31789 DUF336 family protein AlphaFold + ColabFold – – 0.538 No Hit 0.0% —
340 KP13_31788 hypothetical protein ColabFold – – 0.501 No Hit 0.0% —
341 KP13_31786 hypothetical protein AlphaFold + ColabFold – – 0.758 No Hit 0.0% —
342 KP13_31785 hypothetical protein AlphaFold + ColabFold – – 0.461 No Hit 0.0% —
343 KP13_31784 hypothetical protein ColabFold – – 0.428 No Hit 0.0% —
344 KP13_31783 hypothetical protein AlphaFold + ColabFold – – 0.146 No Hit 0.0% —
345 KP13_31782 putative phospholipid ABC transporter-binding protein mlaD mlaD AlphaFold + ColabFold –
GO:0015914The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. GO:0005543Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. GO:0005548OBSOLETE. Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.
0.201 No Hit 0.0% —
346 KP13_31781 hypothetical protein ColabFold – – 0.591 No Hit 0.0% —
347 KP13_31780 hypothetical protein ColabFold – – 0.881 No Hit 0.0% —
348 KP13_31779 Oxaloacetate decarboxylase beta chain AlphaFold + ColabFold
7.2.4.2
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.824 No Hit 0.0% —
349 KP13_31778 arginine repressor argR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.395 No Hit 0.0% —
350 KP13_31777 hypothetical protein AlphaFold + ColabFold – – 0.443 No Hit 0.0% —
Page of 234 · 5842 total proteins