Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3526 KP13_04810 type IV secretion system VirB5 component AlphaFold + ColabFold – – 0.4 No Hit 0.0% —
3527 KP13_03061 putative ThiJ/PfpI family peptidase AlphaFold + ColabFold – – 0.4 No Hit 0.0% —
3528 KP13_01497 hypothetical protein AlphaFold + ColabFold – – 0.4 No Hit 0.0% —
3529 KP13_01486 Sulphatase-modifying factor domain-containing protein AlphaFold + ColabFold
2.7.11.1
GO:0120147Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O. GO:0004674Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
0.399 Hit 37.3% 3.40e-07
3530 KP13_02631 hypothetical protein AlphaFold + ColabFold – – 0.398 No Hit 0.0% —
3531 KP13_02519 Protein-L-isoaspartate O-methyltransferase pcm AlphaFold + ColabFold
2.1.1.77
GO:0004719Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.398 Hit 35.0% 6.73e-15
3532 KP13_01098 tRNA pseudouridine synthase B truB AlphaFold + ColabFold
5.4.99.25
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0009982Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. +58 total
0.398 Hit 41.5% 3.73e-08
3533 KP13_00751 50S ribosomal protein L23 rplW AlphaFold + ColabFold –
GO:0019843Binding to a ribosomal RNA. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +14 total
0.398 Hit 35.9% 4.60e-06
3534 KP13_31813 hypothetical protein AlphaFold + ColabFold – – 0.397 No Hit 0.0% —
3535 KP13_05183 hypothetical protein AlphaFold + ColabFold – – 0.397 No Hit 0.0% —
3536 KP13_02796 Outer membrane protein tolC tolC AlphaFold + ColabFold –
GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
0.397 No Hit 0.0% —
3537 KP13_00970 hypothetical protein AlphaFold + ColabFold – – 0.397 No Hit 0.0% —
3538 KP13_00909 hypothetical protein AlphaFold + ColabFold – – 0.397 No Hit 0.0% —
3539 KP13_05516 N-carbamoyl-L-amino acid hydrolase AlphaFold + ColabFold –
GO:0016813Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.396 No Hit 0.0% —
3540 KP13_04878 Medium-chain-fatty-acid--CoA ligase alkK AlphaFold + ColabFold
6.2.1.25
GO:0018858Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate. GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
0.396 Hit 28.6% 1.05e-14
3541 KP13_03549 hypothetical protein AlphaFold + ColabFold – – 0.396 No Hit 0.0% —
3542 KP13_02812 putative transmembrane protein AlphaFold + ColabFold – – 0.396 No Hit 0.0% —
3543 KP13_01356 50S ribosomal protein L1 rplA AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0015934The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). +58 total
0.396 No Hit 0.0% —
3544 KP13_00452 Phosphonates transport ATP-binding protein phnK phnK AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0019700The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. +14 total
0.396 Hit 33.7% 3.22e-06
3545 KP13_31778 arginine repressor argR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.395 No Hit 0.0% —
3546 KP13_06696 hypothetical protein AlphaFold + ColabFold – – 0.395 No Hit 0.0% —
3547 KP13_04073 hypothetical protein AlphaFold + ColabFold – – 0.395 No Hit 0.0% —
3548 KP13_02993 Galactokinase galK AlphaFold + ColabFold
2.7.1.6
GO:0006012The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). +69 total
0.395 Hit 43.8% 1.29e-91
3549 KP13_01837 General secretion pathway protein D pulD Experimental + AlphaFold + ColabFold –
GO:0009306The controlled release of proteins from a cell. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. +36 total
0.395 No Hit 0.0% —
3550 KP13_01674 hypothetical protein AlphaFold + ColabFold – – 0.395 No Hit 0.0% —
Page of 208 · 5192 total proteins