Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4276 KP13_02129 matC family protein AlphaFold + ColabFold – – 0.268 No Hit 0.0% —
4277 KP13_00799 Thioredoxin-2 trxC AlphaFold + ColabFold –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
0.268 Hit 39.7% 1.68e-11
4278 KP13_10184 30S ribosomal protein S8 rpsH AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +36 total
0.267 No Hit 0.0% —
4279 KP13_03460 Transcriptional activator ramA ramA Experimental + AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.267 No Hit 0.0% —
4280 KP13_02088 Phosphate starvation-inducible protein psiF psiF AlphaFold + ColabFold – – 0.267 No Hit 0.0% —
4281 KP13_01233 AraC-family transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.267 No Hit 0.0% —
4282 KP13_00707 Ribulose-phosphate 3-epimerase rpe AlphaFold + ColabFold
5.1.3.1
GO:0004750Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016857Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. +47 total
0.267 Hit 39.5% 1.96e-39
4283 KP13_00690 Phosphoenolpyruvate carboxykinase pckA AlphaFold + ColabFold
4.1.1.49
GO:0017076Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. +47 total
0.267 No Hit 0.0% —
4284 KP13_00447 hypothetical protein AlphaFold + ColabFold – – 0.267 No Hit 0.0% —
4285 KP13_00443 D-ribose-binding periplasmic protein AlphaFold + ColabFold – – 0.267 No Hit 0.0% —
4286 KP13_32168 hypothetical protein AlphaFold + ColabFold – – 0.266 No Hit 0.0% —
4287 KP13_05103 putative LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.266 No Hit 0.0% —
4288 KP13_04816 hypothetical protein AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:1900378Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.
0.266 No Hit 0.0% —
4289 KP13_01867 hypothetical protein AlphaFold + ColabFold – – 0.266 No Hit 0.0% —
4290 KP13_13547 Tryptophanyl-tRNA synthetase AlphaFold + ColabFold
6.1.1.2
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0006436The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0006418The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. +47 total
0.265 Hit 27.6% 3.93e-26
4291 KP13_04992 Arginine N-succinyltransferase AlphaFold + ColabFold
2.3.1.109
GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0008791Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+.
0.265 No Hit 0.0% —
4292 KP13_03804 putative glycosyltransferase family 2 in cps region rfbN AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
0.265 No Hit 0.0% —
4293 KP13_03357 Alkyl hydroperoxide reductase subunit C ahpC AlphaFold + ColabFold
1.11.1.26
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH. +710 total
0.265 Hit 43.4% 3.99e-17
4294 KP13_02784 DNA topoisomerase 4 subunit A parC AlphaFold + ColabFold
5.6.2.2
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. +811 total
0.265 Hit 27.3% 2.00e-09
4295 KP13_02267 Diaminopimelate decarboxylase lysA AlphaFold + ColabFold
4.1.1.20
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008836Catalysis of the reaction: meso-2,6-diaminopimelate + H+ = L-lysine + CO2. +14 total
0.265 No Hit 0.0% —
4296 KP13_31960 hypothetical protein AlphaFold + ColabFold – – 0.264 No Hit 0.0% —
4297 KP13_04899 hypothetical protein AlphaFold + ColabFold – – 0.264 No Hit 0.0% —
4298 KP13_04175 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
0.264 No Hit 0.0% —
4299 KP13_03323 Magnesium and cobalt efflux protein corC corC AlphaFold + ColabFold –
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.264 Hit 31.5% 1.56e-13
4300 KP13_01982 hypothetical protein AlphaFold + ColabFold – – 0.264 No Hit 0.0% —
Page of 208 · 5192 total proteins