Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4351 KP13_00686 hypothetical protein AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0006139Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.251 Hit 37.9% 8.37e-07
4352 KP13_05496 HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.25 No Hit 0.0% —
4353 KP13_01507 hypothetical protein AlphaFold + ColabFold – – 0.25 No Hit 0.0% —
4354 KP13_01172 hypothetical protein AlphaFold + ColabFold – – 0.25 No Hit 0.0% —
4355 KP13_00827 signal transduction response regulator protein AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. +36 total
0.25 No Hit 0.0% —
4356 KP13_00335 Sulfurtransferase tusA tusA AlphaFold + ColabFold –
GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0002143The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.25 No Hit 0.0% —
4357 KP13_32105 type IV conjugative transfer system VirB1-like protein AlphaFold + ColabFold – – 0.248 No Hit 0.0% —
4358 KP13_31561 DNA-3-methyladenine glycosylase 1 tag AlphaFold + ColabFold
3.2.2.20
GO:0008725Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site. GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
0.248 No Hit 0.0% —
4359 KP13_06878 hypothetical protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.248 No Hit 0.0% —
4360 KP13_05211 PTS family enzyme IIA/FPr AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0090563Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +14 total
0.248 No Hit 0.0% —
4361 KP13_04866 Adenylosuccinate lyase purB AlphaFold + ColabFold
4.3.2.2
GO:0009152The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004018Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. +58 total
0.248 Hit 23.2% 5.01e-07
4362 KP13_04801 hypothetical protein AlphaFold + ColabFold – – 0.248 No Hit 0.0% —
4363 KP13_02554 HTH-type transcriptional regulator galR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.248 No Hit 0.0% —
4364 KP13_01793 Lysine decarboxylase, constitutive ldcC AlphaFold + ColabFold
4.1.1.18
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. +69 total
0.248 No Hit 0.0% —
4365 KP13_01037 Penicillin-insensitive murein endopeptidase mepA AlphaFold + ColabFold
3.4.24.-
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +36 total
0.248 No Hit 0.0% —
4366 KP13_00930 HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.248 No Hit 0.0% —
4367 KP13_32107 hypothetical protein AlphaFold + ColabFold – – 0.247 No Hit 0.0% —
4368 KP13_05562 Phosphoglycerate transport system transcriptional regulatory protein pgtA pgtA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. +25 total
0.247 No Hit 0.0% —
4369 KP13_02311 putative propanediol utilization protein AlphaFold + ColabFold –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
0.247 No Hit 0.0% —
4370 KP13_01852 DnaK suppressor protein dksA AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0010468Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
0.247 No Hit 0.0% —
4371 KP13_01343 putative 5-methylcytosine-specific restriction enzyme with GTPase AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.247 No Hit 0.0% —
4372 KP13_01762 DNA helicase domain-containing protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
0.246 No Hit 0.0% —
4373 KP13_01044 hypothetical protein AlphaFold + ColabFold – – 0.246 No Hit 0.0% —
4374 KP13_05097 putative ABC transporter ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.245 Hit 32.5% 4.83e-12
4375 KP13_02506 hypothetical protein AlphaFold + ColabFold – – 0.245 No Hit 0.0% —
Page of 208 · 5192 total proteins