Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4451 KP13_04708 putative transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.727 No Hit 0.0% —
4452 KP13_04709 Respiratory nitrate reductase 1 gamma chain narI AlphaFold + ColabFold
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0008940Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +69 total
No map 0.979 No Hit 0.0% —
4453 KP13_04710 Respiratory nitrate reductase 1 delta chain narJ AlphaFold + ColabFold –
GO:0051131The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. GO:0051082Binding to an unfolded protein. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.645 No Hit 0.0% —
4454 KP13_04711 Respiratory nitrate reductase 1 beta chain narH AlphaFold + ColabFold
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0042126The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid. GO:0008940Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. +811 total
No map 0.454 No Hit 0.0% —
4455 KP13_04712 Respiratory nitrate reductase 1 alpha chain narG AlphaFold + ColabFold
1.7.5.1
GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +811 total
No map 0.983 No Hit 0.0% —
4456 KP13_04713 Nitrite extrusion protein 1 narK AlphaFold + ColabFold –
GO:0015707The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015112Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +710 total
No map 0.818 No Hit 0.0% —
4457 KP13_04714 Nitrate/nitrite sensor protein narX narX AlphaFold + ColabFold
2.7.13.3
GO:0004673Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +58 total
No map 0.77 No Hit 0.0% —
4458 KP13_04715 Nitrate/nitrite response regulator protein narL narL AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
No map 0.349 No Hit 0.0% —
4459 KP13_04716 hypothetical protein AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No map 0.748 No Hit 0.0% —
4460 KP13_04717 Nitrate reductase nasA AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0043546Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
No map 0.463 No Hit 0.0% —
4461 KP13_04720 Nitrate transport permease protein nrtB nrtB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0015112Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. +47 total
No map 0.952 No Hit 0.0% —
4462 KP13_04721 Nitrate transport protein nrtA nrtA AlphaFold + ColabFold –
GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
No map 0.532 No Hit 0.0% —
4463 KP13_04722 Nitrate regulatory protein nasR AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof.
No map 0.802 No Hit 0.0% —
4464 KP13_04723 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.005 No Hit 0.0% —
4465 KP13_04725 Leu/Ile/Val-binding protein AlphaFold + ColabFold –
GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015820The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.538 No Hit 0.0% —
4466 KP13_04726 putative aromatic amino acid transporter AlphaFold + ColabFold –
GO:0003333The process in which an amino acid is transported across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.602 No Hit 0.0% —
4467 KP13_04728 putative glucose-6-phosphate 1-epimerase AlphaFold + ColabFold
5.1.3.15
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +36 total
No map 0.171 No Hit 0.0% —
4468 KP13_04730 MltA-interacting protein mipA AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.
No map 0.84 No Hit 0.0% —
4469 KP13_04731 PrkA family protein AlphaFold + ColabFold
2.7.11.1
GO:0004672Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004674Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
No map 0.468 No Hit 0.0% —
4470 KP13_04732 hypothetical protein AlphaFold + ColabFold – – No map 0.924 No Hit 0.0% —
4471 KP13_04733 hypothetical protein AlphaFold + ColabFold – – No map 0.808 No Hit 0.0% —
4472 KP13_04735 hypothetical protein AlphaFold + ColabFold – – No map 0.776 No Hit 0.0% —
4473 KP13_04738 hypothetical protein ColabFold – – No map 0.501 No Hit 0.0% —
4474 KP13_04739 putative sugar efflux transporter sotB AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.994 No Hit 0.0% —
4475 KP13_04741 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.845 No Hit 0.0% —
Page of 234 · 5842 total proteins