Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
476 KP13_00255 Major facilitator superfamily protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.932 Hit 24.3% 3.51e-11
477 KP13_31627 SMP-30/Gluconolaconase/LRE domain-containing protein AlphaFold + ColabFold –
GO:0005509Binding to a calcium ion (Ca2+). GO:0004341Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. GO:0019853The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
0.931 Hit 30.4% 1.91e-31
478 KP13_31545 hypothetical protein AlphaFold + ColabFold – – 0.931 No Hit 0.0% —
479 KP13_06745 hypothetical protein AlphaFold + ColabFold – – 0.931 No Hit 0.0% —
480 KP13_05459 L-Ala-D/L-Glu epimerase AlphaFold + ColabFold
5.1.1.-
GO:0016855Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. GO:0009063The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. GO:0046872Binding to a metal ion.
0.931 No Hit 0.0% —
481 KP13_04515 Methyl viologen resistance protein smvA smvA AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.931 No Hit 0.0% —
482 KP13_04251 Putrescine transport system permease protein potI potI AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.931 No Hit 0.0% —
483 KP13_03447 Amidase, hydantoinase/carbamoylase family protein AlphaFold + ColabFold –
GO:0016813Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.93 No Hit 0.0% —
484 KP13_03287 putative transmembrane protein AlphaFold + ColabFold – – 0.93 No Hit 0.0% —
485 KP13_01023 Bifunctional protein folC folC AlphaFold + ColabFold –
GO:0004326Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0016881Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. +710 total
0.93 Hit 37.4% 2.53e-29
486 KP13_31562 Phosphoethanolamine transferase eptB eptB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. +47 total
0.929 No Hit 0.0% —
487 KP13_04928 major facilitator family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.929 No Hit 0.0% —
488 KP13_04777 HTH-type transcriptional regulator cbl cbl AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +14 total
0.929 No Hit 0.0% —
489 KP13_04267 Inner membrane protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.929 No Hit 0.0% —
490 KP13_03721 putative flavin-containing monoamine oxidase AofH AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.929 No Hit 0.0% —
491 KP13_02207 hypothetical protein AlphaFold + ColabFold – – 0.929 No Hit 0.0% —
492 KP13_01462 Protein methyltransferase hemK hemK AlphaFold + ColabFold
2.1.1.297
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003676Binding to a nucleic acid. GO:0006479The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. +36 total
0.929 Hit 29.9% 2.53e-17
493 KP13_32244 multidrug efflux protein EmrE emrE AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +58 total
0.928 No Hit 0.0% —
494 KP13_31524 2,3-dihydroxyphenylpropionate/2, 3-dihydroxicinnamic acid 1,2-dioxygenase mhpB AlphaFold + ColabFold
1.13.11.16
GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. GO:0047070Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. +47 total
0.928 No Hit 0.0% —
495 KP13_05359 Tryptophan synthase alpha chain trpA AlphaFold + ColabFold –
GO:0004834Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. GO:0006568The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
0.928 No Hit 0.0% —
496 KP13_05119 putative glyoxalase AlphaFold + ColabFold – – 0.928 No Hit 0.0% —
497 KP13_04911 PTS system glucose-specific EIICB component ptsG AlphaFold + ColabFold
2.7.1.199
GO:1904659The process in which D-glucose is transported across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005355OBSOLETE. Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. +69 total
0.928 No Hit 0.0% —
498 KP13_01935 Thiamine-binding periplasmic protein thiB AlphaFold + ColabFold –
GO:0030975Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0015888The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.928 No Hit 0.0% —
499 KP13_01697 Protein wzxE wzxE AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria.
0.928 No Hit 0.0% —
500 KP13_00657 Quercetin 2,3-dioxygenase AlphaFold + ColabFold – – 0.928 Hit 31.8% 2.80e-07
Page of 208 · 5192 total proteins