Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5126 KP13_05637 hypothetical protein ColabFold – – 0.54 No Hit 0.0% —
5127 KP13_05638 hypothetical protein ColabFold – – 0.883 No Hit 0.0% —
5128 KP13_05639 hypothetical protein ColabFold – – 0.506 No Hit 0.0% —
5129 KP13_05640 DNA-invertase gin ColabFold –
GO:0000150Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.782 No Hit 0.0% —
5130 KP13_05642 hypothetical protein AlphaFold + ColabFold – – 0.576 No Hit 0.0% —
5131 KP13_05643 hypothetical protein AlphaFold + ColabFold – – 0.383 No Hit 0.0% —
5132 KP13_05645 hypothetical protein ColabFold – – 0.503 No Hit 0.0% —
5133 KP13_05646 hypothetical protein ColabFold – – 0.071 No Hit 0.0% —
5134 KP13_05648 Phosphotransferase system EIIB/cysteine AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
0.504 No Hit 0.0% —
5135 KP13_05649 hypothetical protein AlphaFold + ColabFold – – 0.366 No Hit 0.0% —
5136 KP13_05655 Pullulanase secretion protein pulS pulS Experimental + AlphaFold + ColabFold –
GO:0006886The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
0.542 No Hit 0.0% —
5137 KP13_05657 hypothetical protein AlphaFold + ColabFold – – 0.449 No Hit 0.0% —
5138 KP13_05658 HNH endonuclease domain-containing protein AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0008270Binding to a zinc ion (Zn). GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
0.227 No Hit 0.0% —
5139 KP13_05660 Pyrazinamidase/nicotinamidase pncA AlphaFold + ColabFold
3.5.1.19
GO:0046872Binding to a metal ion. GO:0008936Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH4+. GO:0019363The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base.
0.45 No Hit 0.0% —
5140 KP13_05662 Protease 4 sppA AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006465OBSOLETE. The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.492 No Hit 0.0% —
5141 KP13_05663 Putative NAD(P)H nitroreductase Experimental + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.872 No Hit 0.0% —
5142 KP13_05669 hypothetical protein AlphaFold + ColabFold – – 0.489 No Hit 0.0% —
5143 KP13_05672 putative transposase AlphaFold + ColabFold –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.739 No Hit 0.0% —
5144 KP13_05682 hypothetical protein AlphaFold + ColabFold – – 0.562 No Hit 0.0% —
5145 KP13_05697 hypothetical protein AlphaFold + ColabFold – – 0.211 No Hit 0.0% —
5146 KP13_05698 hypothetical protein AlphaFold + ColabFold – – 0.37 No Hit 0.0% —
5147 KP13_05699 Transposon Tn3 resolvase AlphaFold + ColabFold –
GO:0000150Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.409 No Hit 0.0% —
5148 KP13_05711 hypothetical protein ColabFold – – 0.565 No Hit 0.0% —
5149 KP13_05719 Propanediol utilization protein pduA AlphaFold + ColabFold –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
0.532 No Hit 0.0% —
5150 KP13_05720 Resolvase AlphaFold + ColabFold –
GO:0000150Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.394 No Hit 0.0% —
Page of 234 · 5842 total proteins