Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5626 KP13_31969 Type IV secretion system protein IcmF (I-T4SS) AlphaFold + ColabFold – – 0.894 No Hit 0.0% —
5627 KP13_31971 hypothetical protein AlphaFold + ColabFold – – 0.36 No Hit 0.0% —
5628 KP13_31972 hypothetical protein AlphaFold + ColabFold – – 0.535 No Hit 0.0% —
5629 KP13_31976 Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive AlphaFold + ColabFold
2.5.1.54
GO:0003849Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). +47 total
0.376 No Hit 0.0% —
5630 KP13_31977 hypothetical protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.957 No Hit 0.0% —
5631 KP13_31979 hypothetical protein AlphaFold + ColabFold – – 0.254 No Hit 0.0% —
5632 KP13_31980 hypothetical protein AlphaFold + ColabFold – – 0.434 No Hit 0.0% —
5633 KP13_31981 PTS system sucrose-specific EIIBC component scrA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +47 total
0.609 No Hit 0.0% —
5634 KP13_31983 Thiosulfate sulfurtransferase AlphaFold + ColabFold –
GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+.
0.696 No Hit 0.0% —
5635 KP13_31985 hypothetical protein ColabFold – – 0.636 No Hit 0.0% —
5636 KP13_31987 hypothetical protein ColabFold – – 0.87 No Hit 0.0% —
5637 KP13_31989 LysR-family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.845 No Hit 0.0% —
5638 KP13_31990 transcriptional regulator, AraC family AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.454 No Hit 0.0% —
5639 KP13_31992 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.549 No Hit 0.0% —
5640 KP13_31993 glucan biosynthesis protein D mdoD AlphaFold + ColabFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +47 total
0.945 No Hit 0.0% —
5641 KP13_31994 hypothetical protein AlphaFold + ColabFold – – 0.24 No Hit 0.0% —
5642 KP13_31995 putative reverse transcriptase AlphaFold + ColabFold – – 0.062 No Hit 0.0% —
5643 KP13_31996 putative transposase AlphaFold + ColabFold – – 0.546 No Hit 0.0% —
5644 KP13_31999 putative HTH-type transcription regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.945 No Hit 0.0% —
5645 KP13_32001 hypothetical protein ColabFold – – 0.619 No Hit 0.0% —
5646 KP13_32003 hypothetical protein AlphaFold + ColabFold – – 0.21 No Hit 0.0% —
5647 KP13_32004 biofilm-dependent modulation domain-containing protein AlphaFold + ColabFold –
GO:0071468Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
0.029 No Hit 0.0% —
5648 KP13_32005 Cyd operon protein ColabFold – – 0.729 No Hit 0.0% —
5649 KP13_32007 hypothetical protein AlphaFold + ColabFold – – 0.233 No Hit 0.0% —
5650 KP13_32009 hypothetical protein AlphaFold + ColabFold – – 0.759 No Hit 0.0% —
Page of 234 · 5842 total proteins