Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
601 KP13_00935 Beta-lactamase-related protein AlphaFold DB model + ColabFold model – – No map 0.808 No Hit 0.0% —
602 KP13_00937 Putative aga operon transcriptional repressor agaR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.451 No Hit 0.0% —
603 KP13_00938 Nucleoid-associated protein ndpA ndpA AlphaFold DB model + ColabFold model –
GO:0009295The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.237 No Hit 0.0% —
604 KP13_00939 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.61 No Hit 0.0% —
605 KP13_00940 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.992 No Hit 0.0% —
606 KP13_00941 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.941 No Hit 0.0% —
607 KP13_00942 Ecotin eco AlphaFold DB model + ColabFold model –
GO:0004867Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.241 No Hit 0.0% —
608 KP13_00943 putative malate:quinone oxidoreductase mqo AlphaFold DB model + ColabFold model
1.1.5.4
GO:0008924Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol. Vitamin K (menaquinone) and several other quinones can act as acceptors. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0047545Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
No map 0.945 No Hit 0.0% —
609 KP13_00944 hypothetical protein ColabFold model – – No map 0.373 No Hit 0.0% —
610 KP13_00945 Magnesium transporter AlphaFold DB model + ColabFold model –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0015693The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015095Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. +47 total
No map 0.531 No Hit 0.0% —
611 KP13_00949 Thiamine biosynthesis lipoprotein apbE apbE AlphaFold DB model + ColabFold model
2.7.1.180
GO:0017013The addition of a flavin group to a protein amino acid. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. +14 total
No map 0.49 No Hit 0.0% —
612 KP13_00950 Outer membrane protein C OmpK36 ompC AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034220A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. +25 total
No map 0.686 No Hit 0.0% —
613 KP13_00951 hypothetical protein ColabFold model – – No map 0.444 No Hit 0.0% —
614 KP13_00952 Sensor-like histidine kinase AlphaFold DB model + ColabFold model
2.7.2.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0009927Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. +25 total
No map 0.906 No Hit 0.0% —
615 KP13_00953 Capsular synthesis regulator component B rcsB AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.409 No Hit 0.0% —
616 KP13_00954 Sensor kinase protein rcsC rcsC AlphaFold DB model + ColabFold model
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0018106The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. +811 total
No map 0.489 No Hit 0.0% —
617 KP13_00957 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.838 No Hit 0.0% —
618 KP13_00963 Anaerobic glycerol-3-phosphate dehydrogenase subunit B glpB AlphaFold DB model + ColabFold model
1.1.5.3
GO:0004368Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. GO:0009331An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions. GO:0019563The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
No map 0.733 No Hit 0.0% —
619 KP13_00964 Anaerobic glycerol-3-phosphate dehydrogenase subunit C glpC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009061The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +58 total
No map 0.995 No Hit 0.0% —
620 KP13_00965 2-keto-3-deoxy-L-rhamnonate aldolase AlphaFold DB model + ColabFold model
4.1.2.53
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.143 No Hit 0.0% —
621 KP13_00967 L-rhamnonate dehydratase AlphaFold DB model + ColabFold model
4.2.1.90
GO:0050032Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O. GO:0009063The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. GO:0000287Binding to a magnesium (Mg) ion. +14 total
No map 0.695 No Hit 0.0% —
622 KP13_00968 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.506 No Hit 0.0% —
623 KP13_00970 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.397 No Hit 0.0% —
624 KP13_00971 putative transposase AlphaFold DB model + ColabFold model –
GO:1990238Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.569 No Hit 0.0% —
625 KP13_00972 Nucleoside triphosphatase nudI nudI Experimental + ColabFold model
3.6.1.9 3.6.1.12 3.6.1.- +14 total
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0047840Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate. +25 total
No map 0.472 No Hit 0.0% —
Page of 234 · 5842 total proteins