Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
751 KP13_05591 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.251 No Hit 0.0% —
752 KP13_05590 dicarboxylate transport domain-containing protein AlphaFold DB model + ColabFold model – – No map 0.975 No Hit 0.0% —
753 KP13_05589 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.736 No Hit 0.0% —
754 KP13_05587 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.323 No Hit 0.0% —
755 KP13_05586 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.073 No Hit 0.0% —
756 KP13_05585 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.175 No Hit 0.0% —
757 KP13_05584 putative pyruvate-flavodoxin oxidoreductase AlphaFold DB model + ColabFold model
1.2.7.-
GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0016903Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +58 total
No map 0.964 No Hit 0.0% —
758 KP13_05582 thermonuclease family protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.292 No Hit 0.0% —
759 KP13_05578 putative transposase AlphaFold DB model + ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.809 No Hit 0.0% —
760 KP13_05574 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.511 No Hit 0.0% —
761 KP13_05573 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.296 No Hit 0.0% —
762 KP13_05572 putative acetyltransferase protein ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.858 No Hit 0.0% —
763 KP13_05571 hypothetical protein ColabFold model – – No map 0.392 No Hit 0.0% —
764 KP13_05569 Lactonase drp35 drp35 AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.757 No Hit 0.0% —
765 KP13_05566 LysR family transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.935 No Hit 0.0% —
766 KP13_05565 insertion element IS1 protein insA AlphaFold DB model + ColabFold model –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
No map 0.438 No Hit 0.0% —
767 KP13_05564 insertion element IS1 protein InsB ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.324 No Hit 0.0% —
768 KP13_05563 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.719 No Hit 0.0% —
769 KP13_05562 Phosphoglycerate transport system transcriptional regulatory protein pgtA pgtA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. +25 total
No map 0.247 No Hit 0.0% —
770 KP13_05561 Phosphoglycerate transport system sensor protein pgtB pgtB AlphaFold DB model + ColabFold model
2.7.13.3
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. +25 total
No map 0.967 No Hit 0.0% —
771 KP13_05560 Phosphoglycerate transport regulatory protein pgtC pgtC AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
No map 0.765 No Hit 0.0% —
772 KP13_05559 hypothetical protein ColabFold model – – No map 0.433 No Hit 0.0% —
773 KP13_05558 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.956 No Hit 0.0% —
774 KP13_05556 LysM domain/BON superfamily protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.055 No Hit 0.0% —
775 KP13_05555 putative hydrolase AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.685 No Hit 0.0% —
Page of 234 · 5842 total proteins