Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
951 KP13_01779 Methionine import ATP-binding protein metN 1 metN1 AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0033232Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out). GO:0048473The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.434 Hit 67.6% 1.01e-07
952 KP13_00464 Melibiose carrier protein melB AlphaFold + ColabFold –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
0.944 Hit 27.4% 1.04e-07
953 KP13_01177 Malonate decarboxylase subunit beta mdcD AlphaFold + ColabFold –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. +36 total
0.771 Hit 28.6% 1.06e-07
954 KP13_00721 Acetylornithine/succinyldiaminopimelate aminotransferase bifunctional protein argD AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +25 total
0.552 Hit 38.6% 1.07e-07
955 KP13_02996 putative molybdenum transport ATP-binding protein modF modF AlphaFold + ColabFold
3.6.3.17
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.774 Hit 29.0% 1.08e-07
956 KP13_03899 Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase puuC AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0004030Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
0.507 Hit 54.3% 1.09e-07
957 KP13_01206 Putative glycerophosphoryl diester phosphodiesterase AlphaFold + ColabFold
3.1.4.46
GO:0008081Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0008889Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.
0.456 Hit 37.9% 1.16e-07
958 KP13_01318 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase iolD AlphaFold + ColabFold –
GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0016823Catalysis of the hydrolysis of any carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group. GO:0000287Binding to a magnesium (Mg) ion. +25 total
0.87 Hit 31.8% 1.18e-07
959 KP13_04663 Vitamin B12 import ATP-binding protein btuD btuD AlphaFold + ColabFold
7.6.2.8
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015889The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.823 Hit 29.9% 1.20e-07
960 KP13_04260 Glutaredoxin-1 grxA AlphaFold + ColabFold –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. +47 total
0.391 Hit 32.1% 1.21e-07
961 KP13_02709 alpha/beta hydrolase fold domain-containing protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.753 Hit 38.9% 1.22e-07
962 KP13_04773 Putative quinone oxidoreductase AlphaFold + ColabFold
1.3.1.95 1.3.1.84 1.6.5.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0043958Catalysis of the reaction: propanoyl-CoA + NAD+ = acryloyl-CoA + H+ + NADH. GO:0043957Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+.
0.832 Hit 29.1% 1.23e-07
963 KP13_04982 ATP-dependent RNA helicase hrpA hrpA AlphaFold + ColabFold
3.6.4.13
GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003676Binding to a nucleic acid. +47 total
0.393 Hit 51.2% 1.23e-07
964 KP13_03221 putative MFS general substrate transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.748 Hit 30.7% 1.25e-07
965 KP13_01179 Auxin efflux carrier mdcF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.661 Hit 24.0% 1.26e-07
966 KP13_04925 Ribosomal large subunit pseudouridine synthase C rluC AlphaFold + ColabFold
5.4.99.-
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. +36 total
0.541 Hit 39.0% 1.27e-07
967 KP13_01624 Dihydroneopterin triphosphate pyrophosphatase nudB AlphaFold + ColabFold –
GO:0046656The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. GO:0019177Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate. GO:0008828Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate. +47 total
0.417 Hit 30.6% 1.28e-07
968 KP13_05197 3-oxoacyl-[acyl-carrier-protein] reductase Experimental + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004316Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +14 total
0.892 Hit 43.1% 1.29e-07
969 KP13_03660 Acyl-CoA thioesterase 2 tesB AlphaFold + ColabFold
3.1.2.20
GO:0006637The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.359 Hit 50.0% 1.30e-07
970 KP13_01618 Zinc import ATP-binding protein znuC znuC AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0010043Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. +14 total
0.414 Hit 41.5% 1.32e-07
971 KP13_03436 putative ABC transport system ATP-binding component AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.361 Hit 51.0% 1.33e-07
972 KP13_02118 branched-chain amino acid transport ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
0.128 Hit 31.9% 1.34e-07
973 KP13_03593 Phosphoribosylaminoimidazole carboxylase catalytic subunit purE AlphaFold + ColabFold
5.4.99.18
GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0034023Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
0.468 Hit 26.4% 1.36e-07
974 KP13_03448 putative oligopeptide/dipeptide ABC transporter AlphaFold + ColabFold
7.4.2.9
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
0.359 Hit 32.6% 1.38e-07
975 KP13_04471 putative hydrolase AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0047372Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+. GO:0046464The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
0.391 Hit 50.0% 1.46e-07
Page of 234 · 5842 total proteins