Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
101 KP13_00497 putative microcin-H47 secretion/processing ATP-binding protein mchF mchF AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +710 total
0.803 Hit 47.1% 8.66e-14
102 KP13_00510 Outer membrane lipoprotein blc blc AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0008289Binding to a lipid. GO:0006950Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
0.518 Hit 33.6% 4.14e-07
103 KP13_00513 Fumarate reductase iron-sulfur subunit frdB AlphaFold + ColabFold
1.3.5.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +811 total
0.508 Hit 37.2% 8.45e-11
104 KP13_00516 Putative lysyl-tRNA synthetase poxA AlphaFold + ColabFold
6.3.2.-
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006430The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA. +710 total
0.207 Hit 27.8% 6.40e-31
105 KP13_00519 Phosphatidylserine decarboxylase proenzyme psd AlphaFold + ColabFold
4.1.1.65
GO:0004609Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine. GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.797 Hit 36.5% 4.32e-12
106 KP13_00525 ribokinase-like superfamily protein AlphaFold + ColabFold –
GO:0052855Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + H+ + NAD(P)H + phosphate. GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.338 Hit 29.4% 1.74e-12
107 KP13_00528 DNA mismatch repair protein mutL mutL AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006298A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. GO:0030983Binding to a double-stranded DNA region containing one or more mismatches. +47 total
0.427 Hit 47.5% 2.26e-12
108 KP13_00531 GTP-binding protein hflX hflX AlphaFold + ColabFold –
GO:0005525Binding to GTP, guanosine triphosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. +36 total
0.385 Hit 45.5% 8.71e-06
109 KP13_00532 Protein hflK hflK AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.427 Hit 25.0% 6.71e-06
110 KP13_00533 Protein hflC hflC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0052547Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. +14 total
0.367 Hit 28.1% 7.97e-07
111 KP13_00536 Adenylosuccinate synthetase purA AlphaFold + ColabFold
6.3.4.4
GO:0004019Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate. GO:0006164The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +58 total
0.975 Hit 43.5% 6.13e-09
112 KP13_00538 Ribonuclease R rnr AlphaFold + ColabFold
3.1.13.1
GO:0003676Binding to a nucleic acid. GO:0016070The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. GO:0003723Binding to an RNA molecule or a portion thereof. +58 total
0.555 Hit 34.1% 1.06e-08
113 KP13_00539 23S rRNA (guanosine-2'-O-)-methyltransferase rlmB rlmB AlphaFold + ColabFold
2.1.1.185
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +36 total
0.167 Hit 30.5% 2.58e-18
114 KP13_00540 Protein aidB aidB AlphaFold + ColabFold –
GO:0003995Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
0.981 Hit 29.7% 6.12e-14
115 KP13_00549 tRNA (uracil-5-)-methyltransferase trmA AlphaFold + ColabFold
2.1.1.35
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0030697Catalysis of the reaction: S-adenosyl-L-methionine + uridine54 in tRNA = 5-methyluridine54 in tRNA + H+ + S-adenosyl-L-homocysteine. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +47 total
0.411 Hit 29.2% 1.70e-10
116 KP13_00552 Soluble pyridine nucleotide transhydrogenase sthA AlphaFold + ColabFold
1.6.1.1
GO:0003957Catalysis of the reaction: NADPH + NAD+ = NADP+ + NADH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +47 total
0.129 Hit 49.0% 5.83e-07
117 KP13_00554 Argininosuccinate lyase argH AlphaFold + ColabFold
4.3.2.1
GO:0004056Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0042450OBSOLETE. The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. +14 total
0.592 Hit 70.0% 9.84e-18
118 KP13_00564 5,10-methylenetetrahydrofolate reductase metF AlphaFold + ColabFold
1.5.1.54
GO:0006555The chemical reactions and pathways involving L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. +47 total
0.142 Hit 38.2% 3.52e-24
119 KP13_00567 Metallo-dependent phosphatase AlphaFold + ColabFold –
GO:0009166The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. +58 total
0.692 Hit 31.1% 5.56e-17
120 KP13_00570 Cystathionine gamma-synthase metB AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019346The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. +47 total
0.835 Hit 41.9% 1.26e-88
121 KP13_00578 ATP-dependent hsl protease ATP-binding subunit hslU hslU AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009376A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +36 total
0.618 Hit 29.4% 1.82e-17
122 KP13_00579 1,4-dihydroxy-2-naphthoate octaprenyltransferase menA AlphaFold + ColabFold
2.5.1.74
GO:0004659Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. GO:0046428Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H+ = a 2-demethylmenaquinol + CO2 + diphosphate. +47 total
0.995 Hit 28.9% 2.74e-20
123 KP13_00581 6-phosphofructokinase pfkA AlphaFold + ColabFold
2.7.1.11
GO:0008443Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule. GO:0006002The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +1013 total
0.066 Hit 57.8% 6.10e-09
124 KP13_00582 Cation-efflux pump fieF fieF AlphaFold + ColabFold –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +1013 total
0.985 Hit 23.5% 2.86e-09
125 KP13_00587 Superoxide dismutase Mn sodA AlphaFold + ColabFold
1.15.1.1
GO:0004784Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. GO:0006801The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. GO:0046872Binding to a metal ion. +25 total
0.293 Hit 54.3% 2.20e-11
Page of 234 · 5842 total proteins