Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
151 KP13_03141 Uridine kinase udk AlphaFold + ColabFold
2.7.1.48
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0004849Catalysis of the reaction: ATP + uridine = ADP + UMP. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +58 total
0.556 Hit 37.6% 2.91e-42
152 KP13_00989 NADH-quinone oxidoreductase subunit F nuoF AlphaFold + ColabFold
7.1.1.-
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +36 total
0.769 Hit 54.1% 3.45e-42
153 KP13_03039 Molybdenum cofactor biosynthesis protein C moaC AlphaFold + ColabFold
4.6.1.17
GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0061799Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.
0.472 Hit 48.4% 3.48e-42
154 KP13_31805 Sulfur carrier protein ThiS adenylyltransferase thiF AlphaFold + ColabFold –
GO:0008641Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.159 Hit 41.0% 5.49e-42
155 KP13_02851 Dihydroxyacetone kinase AlphaFold + ColabFold
2.7.1.29
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004371Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. +25 total
0.994 Hit 50.3% 6.54e-42
156 KP13_00831 Serine hydroxymethyltransferase glyA AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0035999The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesize other tetrahydrofolate molecules. GO:0004372Catalysis of the reaction: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine. +25 total
0.418 Hit 57.0% 6.95e-42
157 KP13_03293 Deoxyribodipyrimidine photo-lyase phrB AlphaFold + ColabFold
4.1.99.3
GO:0003904Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +25 total
0.867 Hit 28.0% 7.57e-42
158 KP13_01119 Octaprenyl-diphosphate synthase ispB AlphaFold + ColabFold –
GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
0.903 Hit 31.0% 8.67e-42
159 KP13_31485 Malonyl CoA-acyl carrier protein transacylase fabD AlphaFold + ColabFold
2.3.1.39
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0004314Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.658 Hit 34.3% 1.25e-41
160 KP13_31612 Peptide methionine sulfoxide reductase msrA msrA AlphaFold + ColabFold
1.8.4.11
GO:0008113Catalysis of the reaction: L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033744Catalysis of the reaction: [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol. +14 total
0.021 Hit 70.7% 3.01e-41
161 KP13_00143 Alpha-xylosidase AlphaFold + ColabFold
3.2.1.177
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +25 total
0.212 Hit 29.5% 4.82e-41
162 KP13_31747 1,4-alpha-glucan-branching enzyme glgB AlphaFold + ColabFold
2.4.1.18
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005978The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +47 total
0.384 Hit 25.4% 6.27e-41
163 KP13_03363 Enolase-phosphatase E1 mtnC AlphaFold + ColabFold
3.1.3.77
GO:0043874Catalysis of the reactions:5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. +25 total
0.83 Hit 42.9% 3.32e-40
164 KP13_02055 Queuine tRNA-ribosyltransferase AlphaFold + ColabFold
2.4.2.29
GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0008479Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA. GO:0101030OBSOLETE. The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine. +47 total
0.64 Hit 48.9% 6.42e-40
165 KP13_04751 Adenosylhomocysteinase ahcY AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004013Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. GO:0006730The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. +14 total
0.648 Hit 33.0% 6.62e-40
166 KP13_05467 Diaminobutyrate--2-oxoglutarate aminotransferase dat AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
0.578 Hit 29.7% 1.38e-39
167 KP13_04342 Protein clpV1 clpV1 AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.394 Hit 35.8% 1.74e-39
168 KP13_05200 SMP-30/Gluconolaconase/LRE domain-containing protein AlphaFold + ColabFold –
GO:0005509Binding to a calcium ion (Ca2+). GO:0004341Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. GO:0019853The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
0.546 Hit 32.3% 1.75e-39
169 KP13_03277 2-oxoglutarate dehydrogenase E1 component sucA AlphaFold + ColabFold
1.2.4.2
GO:0016624Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. GO:0004591Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2. GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. +36 total
0.729 Hit 47.1% 1.94e-39
170 KP13_00707 Ribulose-phosphate 3-epimerase rpe AlphaFold + ColabFold
5.1.3.1
GO:0004750Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016857Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. +47 total
0.267 Hit 39.5% 1.96e-39
171 KP13_31803 glycine cleavage system aminomethyltransferase T gcvT AlphaFold + ColabFold –
GO:0006546The chemical reactions and pathways resulting in the breakdown of glycine. GO:0005515Binding to a protein. GO:0004047Catalysis of the reaction: N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4+.
0.944 Hit 34.2% 1.99e-39
172 KP13_03461 RomA protein romA AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0070290Catalysis of the reaction: an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) + H2O = an N-acylethanolamine (NAE) + a 1,2-diacyl-sn-glycero-3-phosphate + H+.
0.408 Hit 31.4% 2.75e-39
173 KP13_05360 putative hydroxypyruvate reductase ttuD AlphaFold + ColabFold –
GO:0008887Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.477 Hit 44.1% 1.01e-38
174 KP13_01853 Glutamyl-Q tRNA(Asp) synthetase gluQ AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +47 total
0.147 Hit 36.9% 4.51e-38
175 KP13_04222 ATP-dependent Clp protease ATP-binding subunit clpA clpA AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0043335The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. +47 total
0.461 Hit 41.7% 6.27e-38
Page of 234 · 5842 total proteins