Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
151 KP13_04918 Acyl carrier protein acpP AlphaFold DB model + ColabFold model –
GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
No map 0.283 Hit 51.9% 2.27e-13
152 KP13_02015 Thymidine phosphorylase deoA AlphaFold DB model + ColabFold model
2.4.2.4
GO:0006206The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. GO:0009032Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). +69 total
No map 0.835 Hit 51.9% 8.49e-09
153 KP13_01765 putative NAD(P)H dehydrogenase quinone Experimental + ColabFold model – – No map 0.26 Hit 51.9% 1.59e-10
154 KP13_05087 Acetyl-CoA acetyltransferase atoB AlphaFold DB model + ColabFold model
2.3.1.9
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0003985Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. +14 total
No map 0.944 Hit 51.7% 4.75e-133
155 KP13_31507 Threonine dehydratase biosynthetic ilvA AlphaFold DB model + ColabFold model
4.3.1.19
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004794Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4. +47 total
No map 0.343 Hit 51.6% 2.26e-14
156 KP13_00858 Nucleoside diphosphate kinase ndk AlphaFold DB model + ColabFold model
2.7.4.6
GO:0006183The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. GO:0006241The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. GO:0004550Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. +47 total
No map 0.721 Hit 51.4% 1.87e-18
157 KP13_02012 Lipoate-protein ligase A lplA AlphaFold DB model + ColabFold model
6.3.1.20
GO:0016979Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). GO:0009249The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. +36 total
No map 0.422 Hit 51.4% 1.51e-17
158 KP13_09671 sn-glycerol-3-phosphate import ATP-binding protein ugpC AlphaFold DB model + ColabFold model –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
No map 0.352 Hit 51.3% 6.51e-06
159 KP13_02107 Taurine import ATP-binding protein TauB tauB AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0042918The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical.
No map 0.413 Hit 51.3% 4.78e-06
160 KP13_03568 Lysyl-tRNA synthetase AlphaFold DB model + ColabFold model
6.1.1.6
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. +912 total
No map 0.755 Hit 51.2% 2.61e-17
161 KP13_02843 Cob(I)yrinic acid a,c-diamide adenosyltransferase AlphaFold DB model + ColabFold model
2.5.1.17
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008817Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
No map 0.507 Hit 51.2% 8.72e-06
162 KP13_04982 ATP-dependent RNA helicase hrpA hrpA AlphaFold DB model + ColabFold model
3.6.4.13
GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003676Binding to a nucleic acid. +47 total
No map 0.393 Hit 51.2% 1.23e-07
163 KP13_04219 ATP-binding/permease protein cydC cydC AlphaFold DB model + ColabFold model –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +811 total
No map 0.904 Hit 51.1% 5.13e-07
164 KP13_03168 Ribitol 2-dehydrogenase rbtD AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.636 Hit 51.1% 1.76e-06
165 KP13_03604 Protein qmcA qmcA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map 0.826 Hit 51.0% 5.95e-07
166 KP13_03436 putative ABC transport system ATP-binding component AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.361 Hit 51.0% 1.33e-07
167 KP13_00811 GTP-binding protein lepA lepA AlphaFold DB model + ColabFold model
3.6.5.n1
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +47 total
No map 0.546 Hit 50.9% 1.37e-09
168 KP13_01632 Copper homeostasis protein cutC cutC AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005507Binding to a copper (Cu) ion.
No map 0.329 Hit 50.9% 1.52e-48
169 KP13_04951 hypothetical protein AlphaFold DB model + ColabFold model
3.1.1.106
GO:0061463Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate. Removes the acetyl group from either the 2'' or 3'' position of O-acetyl-ADP-ribose. GO:0001883Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose. GO:0008428Binds to and stops, prevents or reduces the activity of ribonuclease. +14 total
No map 0.404 Hit 50.9% 6.05e-50
170 KP13_01093 Cold-shock DEAD box protein A deaD AlphaFold DB model + ColabFold model
3.6.4.13
GO:0070417Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. GO:0003676Binding to a nucleic acid. GO:0003724Unwinding of an RNA helix, driven by ATP hydrolysis. +912 total
No map 0.46 Hit 50.8% 6.23e-12
171 KP13_01812 Methionine aminopeptidase map AlphaFold DB model + ColabFold model
3.4.11.18
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0070006Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.865 Hit 50.7% 5.43e-17
172 KP13_02286 Thymidylate synthase thyA AlphaFold DB model + ColabFold model
2.1.1.45
GO:0016741Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). GO:0004799Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. GO:0006231The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). +36 total
No map 0.307 Hit 50.7% 8.93e-96
173 KP13_04829 Putative multidrug export ATP-binding/permease protein AlphaFold DB model + ColabFold model –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
No map 0.772 Hit 50.6% 4.14e-17
174 KP13_02087 Pyrroline-5-carboxylate reductase proC AlphaFold DB model + ColabFold model
1.5.1.2
GO:0006561OBSOLETE. The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. GO:0004735Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.363 Hit 50.6% 1.03e-19
175 KP13_04385 ATP-independent RNA helicase dbpA dbpA AlphaFold DB model + ColabFold model
3.6.4.13
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0003724Unwinding of an RNA helix, driven by ATP hydrolysis. +58 total
No map 0.797 Hit 50.5% 6.29e-20
Page of 234 · 5842 total proteins