Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1751 KP13_00825 Putative sensor-like histidine kinase AlphaFold + ColabFold –
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. +14 total
0.706 No Hit 0.0% —
1752 KP13_04252 Putrescine transport system permease protein potH potH AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.705 No Hit 0.0% —
1753 KP13_01952 Transcriptional regulatory protein CitB citB AlphaFold + ColabFold –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.705 No Hit 0.0% —
1754 KP13_05042 Beta-ketoadipyl-CoA thiolase catF AlphaFold + ColabFold
2.3.1.174
GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +14 total
0.704 Hit 46.4% 1.08e-52
1755 KP13_03886 Inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043066Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.704 Hit 30.3% 3.14e-06
1756 KP13_02829 hypothetical protein AlphaFold + ColabFold – – 0.704 No Hit 0.0% —
1757 KP13_02770 Unchacarterized glycoside hydrolase AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond.
0.704 No Hit 0.0% —
1758 KP13_02200 Isopentenyl-diphosphate Delta-isomerase idi AlphaFold + ColabFold
5.3.3.2
GO:0004452Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate. GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.704 Hit 34.6% 9.72e-10
1759 KP13_01014 Histidine transport system permease protein hisM hisM AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +36 total
0.704 No Hit 0.0% —
1760 KP13_00072 hypothetical protein AlphaFold + ColabFold
1.1.99.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.704 No Hit 0.0% —
1761 KP13_32100 F-type conjugal transfer TraG-like protein AlphaFold + ColabFold – – 0.703 No Hit 0.0% —
1762 KP13_31549 HTH-type transcriptional regulator ascG ascG AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.703 No Hit 0.0% —
1763 KP13_04966 Protein maoC maoC AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.703 Hit 29.3% 6.47e-06
1764 KP13_01636 putative symporter AlphaFold + ColabFold –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +14 total
0.703 No Hit 0.0% —
1765 KP13_00520 Putative ribosome biogenesis GTPase RsgA rsgA AlphaFold + ColabFold
3.6.1.-
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.703 No Hit 0.0% —
1766 KP13_05462 hypothetical protein AlphaFold + ColabFold – – 0.702 No Hit 0.0% —
1767 KP13_05253 hypothetical protein AlphaFold + ColabFold – – 0.702 No Hit 0.0% —
1768 KP13_04483 Amidohydrolase family protein AlphaFold + ColabFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.702 No Hit 0.0% —
1769 KP13_01593 Inner membrane protein AlphaFold + ColabFold – – 0.702 No Hit 0.0% —
1770 KP13_02464 putative inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015744The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.701 No Hit 0.0% —
1771 KP13_01376 Endonuclease V nfi AlphaFold + ColabFold
3.1.21.7
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
0.701 Hit 48.6% 7.84e-18
1772 KP13_31890 Isochorismate synthase entC entC AlphaFold + ColabFold
5.4.4.2
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008909Catalysis of the reaction: chorismate = isochorismate. GO:0046872Binding to a metal ion. +14 total
0.7 No Hit 0.0% —
1773 KP13_18751 putative phospholipid import ATP-binding protein mlaF mlaF AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006869The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
0.7 Hit 33.3% 5.19e-09
1774 KP13_05165 Pyridoxamine kinase pdxY AlphaFold + ColabFold
2.7.1.35
GO:0009443Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis. GO:0008478Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.7 Hit 54.8% 8.20e-09
1775 KP13_02159 D-erythrose-4-phosphate dehydrogenase epd AlphaFold + ColabFold
1.2.1.72
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0048001Catalysis of the reaction: D-erythrose 4-phosphate + H2O + NAD+ = 4-phospho-D-erythronate + 2 H+ + NADH. +36 total
0.7 Hit 39.0% 1.80e-32
Page of 208 · 5192 total proteins