Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
176 KP13_00774 50S ribosomal protein L17 rplQ AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
0.617 Hit 34.2% 8.04e-14
177 KP13_00779 Ribosomal RNA small subunit methyltransferase B rsmB AlphaFold + ColabFold
2.1.1.176
GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
0.079 Hit 34.5% 2.37e-23
178 KP13_00780 Methionyl-tRNA formyltransferase fmt AlphaFold + ColabFold
2.1.2.9
GO:0071951The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet). GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
0.607 Hit 35.6% 1.17e-18
179 KP13_00781 Peptide deformylase def AlphaFold + ColabFold –
GO:0042586Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide.
0.03 Hit 32.3% 2.95e-17
180 KP13_00785 Putative ribosome maturation factor rimN rimN AlphaFold + ColabFold
2.7.7.87
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0003725Binding to double-stranded RNA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.598 Hit 27.6% 6.36e-07
181 KP13_00796 CDP-diacylglycerol--serine O-phosphatidyltransferase pssA AlphaFold + ColabFold –
GO:0032049The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008444Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+. +25 total
0.221 Hit 27.7% 2.25e-07
182 KP13_00799 Thioredoxin-2 trxC AlphaFold + ColabFold –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
0.268 Hit 39.7% 1.68e-11
183 KP13_00800 putative tRNA/rRNA methyltransferase AlphaFold + ColabFold –
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +36 total
0.284 Hit 31.9% 1.17e-09
184 KP13_00801 Uracil-DNA glycosylase ung AlphaFold + ColabFold
3.2.2.27
GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. GO:0004844Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. GO:0016799Catalysis of the hydrolysis of any N-glycosyl bond. +36 total
0.357 Hit 64.8% 1.46e-72
185 KP13_00803 ATP-dependent RNA helicase srmB srmB AlphaFold + ColabFold
3.6.4.13
GO:0000027The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. GO:0003676Binding to a nucleic acid. GO:0003724Unwinding of an RNA helix, driven by ATP hydrolysis. +36 total
0.181 Hit 56.5% 2.92e-14
186 KP13_00805 L-aspartate oxidase nadB AlphaFold + ColabFold
1.4.3.16
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008734Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + H2O2. Can also use fumatate as electron acceptor under anaerobic conditions, yielding succinate. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. +36 total
0.347 Hit 33.5% 1.22e-23
187 KP13_00811 GTP-binding protein lepA lepA AlphaFold + ColabFold
3.6.5.n1
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +47 total
0.546 Hit 50.9% 1.37e-09
188 KP13_00813 Ribonuclease 3 rnc AlphaFold + ColabFold
3.1.26.3
GO:0004525Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +912 total
0.374 Hit 35.1% 9.48e-07
189 KP13_00814 GTP-binding protein Era era AlphaFold + ColabFold –
GO:0005525Binding to GTP, guanosine triphosphate. GO:0003723Binding to an RNA molecule or a portion thereof.
0.147 Hit 46.4% 9.03e-07
190 KP13_00821 tRNA-specific adenosine deaminase tadA AlphaFold + ColabFold
3.5.4.33
GO:0008270Binding to a zinc ion (Zn). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0002100The process in which an adenosine at position 34 of a tRNA is post-transcriptionally converted to inosine. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. +36 total
0.564 Hit 48.4% 5.17e-12
191 KP13_00823 Phosphoribosylformylglycinamidine synthase purL AlphaFold + ColabFold
6.3.5.3
GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0004642Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.899 Hit 46.5% 1.55e-06
192 KP13_00829 Flavohemoprotein hmp AlphaFold + ColabFold
1.14.12.17
GO:0008941Catalysis of the reaction: 2 NO + 2 O2 + NAD(P)H + H+ = 2 nitrate + NAD(P)+. GO:0051409Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +811 total
0.032 Hit 26.0% 1.34e-08
193 KP13_00831 Serine hydroxymethyltransferase glyA AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0035999The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesize other tetrahydrofolate molecules. GO:0004372Catalysis of the reaction: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine. +25 total
0.418 Hit 57.0% 6.95e-42
194 KP13_00833 NAGC-like transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006351The synthesis of an RNA transcript from a DNA template.
0.349 Hit 26.5% 5.01e-14
195 KP13_00835 D-xylose-proton symporter xylE AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.873 Hit 34.7% 4.43e-22
196 KP13_00842 Inositol-1-monophosphatase suhB AlphaFold + ColabFold
3.1.3.25
GO:0046854The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. GO:0008934Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +69 total
0.463 Hit 44.1% 1.44e-13
197 KP13_00845 Cysteine desulfurase iscS AlphaFold + ColabFold
2.8.1.7
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. GO:0044571The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. +47 total
0.469 Hit 70.7% 1.30e-29
198 KP13_00846 NifU-like protein nifU AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005506Binding to an iron (Fe) ion. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
0.181 Hit 75.4% 2.18e-69
199 KP13_00848 Co-chaperone protein hscB hscB AlphaFold + ColabFold –
GO:0001671Binds to and increases the activity of an ATP hydrolysis activity. GO:0051259The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. GO:0051087Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. +36 total
0.357 Hit 40.3% 1.93e-10
200 KP13_00849 Chaperone protein hscA hscA AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +36 total
0.878 Hit 44.1% 6.37e-18
Page of 234 · 5842 total proteins