Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2301 KP13_01539 Proteasome subunit alpha/beta domain-containing protein AlphaFold + ColabFold –
GO:0005839A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. GO:0051603OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
No map 0.458 No Hit 0.0% —
2302 KP13_01540 putative transglutaminase AlphaFold + ColabFold – – No map 0.575 No Hit 0.0% —
2303 KP13_01541 hypothetical protein AlphaFold + ColabFold – – No map 0.719 No Hit 0.0% —
2304 KP13_01542 hypothetical protein AlphaFold + ColabFold – – No map 0.516 No Hit 0.0% —
2305 KP13_01543 hypothetical protein AlphaFold + ColabFold – – No map 0.081 No Hit 0.0% —
2306 KP13_01545 Ferrioxamine receptor AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). +25 total
No map 0.603 No Hit 0.0% —
2307 KP13_01546 Endo-type membrane-bound lytic murein transglycosylase A emtA AlphaFold + ColabFold
4.2.2.n1
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000270The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008933Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. +25 total
No map 0.82 No Hit 0.0% —
2308 KP13_01547 Murein tetrapeptide carboxypeptidase ldcA AlphaFold + ColabFold
3.4.17.13
GO:0106415GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map 0.464 No Hit 0.0% —
2309 KP13_01548 Cell volume regulation protein A cvrA AlphaFold + ColabFold –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). GO:1902600The directed movement of a proton across a membrane. +811 total
No map 0.654 No Hit 0.0% —
2310 KP13_01549 Alanine racemase, catabolic dadB AlphaFold + ColabFold
5.1.1.1
GO:0006522OBSOLETE. The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. GO:0008784Catalysis of the reaction: L-alanine = D-alanine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +47 total
No map 0.121 No Hit 0.0% —
2311 KP13_01551 hypothetical protein AlphaFold + ColabFold – – No map 0.623 No Hit 0.0% —
2312 KP13_01552 SpoVR family protein AlphaFold + ColabFold – – No map 0.593 No Hit 0.0% —
2313 KP13_01553 Fatty acid metabolism regulator protein fadR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0019217Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. +47 total
No map 0.53 No Hit 0.0% —
2314 KP13_01554 Na(+)/H(+) antiporter nhaB nhaB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015385Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). +14 total
No map 0.843 No Hit 0.0% —
2315 KP13_01556 YeaR domain-containing protein AlphaFold + ColabFold – – No map 0.874 No Hit 0.0% —
2316 KP13_01557 hypothetical protein AlphaFold + ColabFold – – No map 0.741 No Hit 0.0% —
2317 KP13_01559 YcgL domain-containing protein AlphaFold + ColabFold – – No map 0.544 No Hit 0.0% —
2318 KP13_01560 putative septum site-determining protein minC minC AlphaFold + ColabFold –
GO:0051302Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. GO:0051726Any process that modulates the rate or extent of progression through the cell cycle. GO:0000902The developmental process in which the size or shape of a cell is generated and organized. +25 total
No map 0.596 No Hit 0.0% —
2319 KP13_01562 Cell division topological specificity factor minE AlphaFold + ColabFold –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0032955Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. GO:0042802Binding to an identical protein or proteins.
No map 0.514 No Hit 0.0% —
2320 KP13_01565 hypothetical protein AlphaFold + ColabFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
No map 0.368 No Hit 0.0% —
2321 KP13_01566 M22 peptidase-like protein AlphaFold + ColabFold –
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.605 No Hit 0.0% —
2322 KP13_01567 putative ATP-dependent helicase AlphaFold + ColabFold
5.6.2.3
GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003676Binding to a nucleic acid. +811 total
No map 0.57 No Hit 0.0% —
2323 KP13_01569 hypothetical protein AlphaFold + ColabFold – – No map 0.426 No Hit 0.0% —
2324 KP13_01570 Para-aminobenzoate synthase component 1 pabB AlphaFold + ColabFold
2.6.1.85
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. GO:0046820Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. +36 total
No map 0.82 No Hit 0.0% —
2325 KP13_01573 Diguanylate phosphodiesterase domain-containing protein AlphaFold + ColabFold – – No map 0.697 No Hit 0.0% —
Page of 234 · 5842 total proteins