Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_00025 ATP synthase subunit beta atpD AlphaFold + ColabFold
7.1.2.2
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0046034The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. GO:1902600The directed movement of a proton across a membrane. +69 total
0.523 Hit 71.5% 0.00e+00
2 KP13_00362 Glucose-6-phosphate isomerase pgi AlphaFold + ColabFold
5.3.1.9
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0097367Binding to a carbohydrate derivative. +58 total
0.764 Hit 70.2% 0.00e+00
3 KP13_01964 Carbamoyl-phosphate synthase large chain carB AlphaFold + ColabFold
6.3.4.16 6.3.5.5
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0046872Binding to a metal ion. +69 total
0.918 Hit 44.5% 0.00e+00
4 KP13_02907 Succinate-semialdehyde dehydrogenase [NADP+] gabD AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009450The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA). GO:0009013Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+. +36 total
0.917 Hit 56.5% 0.00e+00
5 KP13_05339 Aconitate hydratase 1 acnA AlphaFold + ColabFold – – 0.824 Hit 53.1% 0.00e+00
6 KP13_31833 Isoleucyl-tRNA synthetase ileS AlphaFold + ColabFold
6.1.1.5
GO:0004822Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+. GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. +710 total
0.944 Hit 36.7% 0.00e+00
7 KP13_31914 Fumarate hydratase class II fumC AlphaFold + ColabFold
4.2.1.2
GO:0006106The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. GO:0045239Any of the heteromeric enzymes that act in the TCA cycle. +69 total
0.806 Hit 61.4% 6.20e-178
8 KP13_03893 Succinate-semialdehyde dehydrogenase [NADP+] AlphaFold + ColabFold –
GO:0009013Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+. GO:0009450The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +36 total
0.933 Hit 53.6% 2.84e-176
9 KP13_03430 Choline dehydrogenase betA AlphaFold + ColabFold
1.1.99.1 1.2.1.8
GO:0019285The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline. GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0008812Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde. +36 total
0.877 Hit 47.8% 4.62e-171
10 KP13_00305 Glutathione reductase gor AlphaFold + ColabFold –
GO:0006749The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. GO:0016668Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +47 total
0.488 Hit 54.3% 5.18e-161
11 KP13_05028 NAD(P) transhydrogenase subunit beta pntB AlphaFold + ColabFold
7.1.1.1
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008750Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+. +14 total
0.989 Hit 52.3% 9.01e-157
12 KP13_00203 putative 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase AlphaFold + ColabFold
2.3.1.29
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +69 total
0.193 Hit 55.4% 1.78e-149
13 KP13_02726 S-adenosylmethionine synthase metK AlphaFold + ColabFold
2.5.1.6
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006556The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. GO:0004478Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. +36 total
0.387 Hit 58.2% 3.00e-144
14 KP13_02494 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase hpcC AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:1901023The chemical reactions and pathways resulting in the breakdown of 4-hydroxyphenylacetate. +14 total
0.699 Hit 42.3% 4.01e-138
15 KP13_15895 Agmatinase AlphaFold + ColabFold
3.5.3.11
GO:0016813Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. GO:0046872Binding to a metal ion. GO:0008783Catalysis of the reaction: agmatine + H2O = putrescine + urea. +25 total
0.531 Hit 61.4% 5.34e-136
16 KP13_01987 Transaldolase 1 tal1 AlphaFold + ColabFold
2.2.1.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004801Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. +25 total
0.128 Hit 60.4% 2.48e-134
17 KP13_05087 Acetyl-CoA acetyltransferase atoB AlphaFold + ColabFold
2.3.1.9
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0003985Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. +14 total
0.944 Hit 51.7% 4.75e-133
18 KP13_32247 Glyceraldehyde-3-phosphate dehydrogenase gapA AlphaFold + ColabFold
1.2.1.-
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. +36 total
0.502 Hit 69.7% 7.91e-128
19 KP13_01100 Translation initiation factor IF-2 infB AlphaFold + ColabFold –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. +36 total
0.644 Hit 41.5% 5.97e-126
20 KP13_03279 Succinate dehydrogenase flavoprotein subunit sdhA AlphaFold + ColabFold
1.3.5.1
GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +69 total
0.582 Hit 63.5% 1.69e-120
21 KP13_02981 Malate dehydrogenase mdh AlphaFold + ColabFold
1.1.1.37
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0006108The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. GO:0019752The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). +69 total
0.863 Hit 59.2% 3.23e-119
22 KP13_04201 Phosphoserine aminotransferase serC Experimental + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006564The chemical reactions and pathways resulting in the formation of L-serine. GO:0004648Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
0.699 Hit 47.8% 1.14e-118
23 KP13_31484 3-oxoacyl-[acyl-carrier-protein] synthase 2 AlphaFold + ColabFold
2.3.1.179
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +25 total
0.967 Hit 44.9% 2.64e-118
24 KP13_05384 Catalase HPII katE AlphaFold + ColabFold
1.11.1.6
GO:0004096Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. +36 total
0.972 Hit 41.0% 1.41e-114
25 KP13_03839 Transaldolase A talA AlphaFold + ColabFold
2.2.1.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004801Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. +25 total
0.508 Hit 60.9% 3.51e-112
Page of 234 · 5842 total proteins