KEGG:map00620

Pyruvate metabolism

KpATCC43816 - Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

All pathways Protein ranking
Reactions 30
Proteins 52
Metabolites 44
Chokepoints 4

Pathway map

Reaction-to-metabolite flow reconstructed from the imported SBML participants.

Chokepoint reaction Metabolite ⇌ Reversible reaction Currency metabolites hidden
Computing layout…

Connected pathways

Other pathways in this genome that share reactions with this one.

MODEL Unassigned metabolic reactions 34 shared KEGG Citrate cycle (TCA cycle) 14 shared KEGG Glycolysis / Gluconeogenesis 6 shared KEGG Glyoxylate and dicarboxylate metabolism 5 shared KEGG Fructose and mannose metabolism 3 shared KEGG Arginine biosynthesis 3 shared KEGG Benzoate degradation 3 shared KEGG Amino sugar and nucleotide sugar metabolism 3 shared KEGG Propanoate metabolism 2 shared KEGG Glycine, serine and threonine metabolism 1 shared KEGG Valine, leucine and isoleucine degradation 1 shared

Reaction table

Catalyzed reactions, mapped genes, and SBML substrates/products.

ALCOHOL-DEHYDROG-RXN

EC 1.1.1.1 · R00754 · ALCOHOL-DEHYDROG-RXN · reversible

ethanol NAD+
⇌
acetaldehyde H+ NADH
No mapped protein

GLYOXII-RXN

EC 3.1.2.6 · R01736 · GLYOXII-RXN · not reversible

consuming
(R)-S-lactoylglutathione H2O
→
(R)-lactate glutathione H+
VK055_2339

GLYOXI-RXN

EC 4.4.1.5 · R02530 · GLYOXI-RXN · not reversible

glutathione methylglyoxal
→
(R)-S-lactoylglutathione
VK055_0487

LACTALDDEHYDROG-RXN

EC 1.2.1.22 · R01446 · LACTALDDEHYDROG-RXN · not reversible

(S)-lactaldehyde H2O NAD+
→
(S)-lactate H+ NADH
No mapped protein

MALIC-NADP-RXN

EC 1.1.1.40 · R00216 · MALIC-NADP-RXN · not reversible

(S)-malate NADP+
→
pyruvate CO2 NADPH
No mapped protein

MALSYN-RXN

EC 2.3.3.9 · R00472 · MALSYN-RXN · not reversible

acetyl-CoA glyoxylate H2O
→
(S)-malate H+ coenzyme A
VK055_3079

PEPCARBOX-RXN

EC 4.1.1.31 · R00345 · PEPCARBOX-RXN · not reversible

hydrogen carbonate phosphoenolpyruvate
→
oxaloacetate phosphate
VK055_3231

PYRUFLAVREDUCT-RXN

EC 1.2.7.1 · R01196 · PYRUFLAVREDUCT-RXN · reversible

an oxidized ferredoxin [iron-sulfur] cluster pyruvate coenzyme A
⇌
a reduced ferredoxin [iron-sulfur] cluster acetyl-CoA CO2 H+
VK055_1056

PYRUVATE-CARBOXYLASE-RXN

EC 6.4.1.1 · R00344 · PYRUVATE-CARBOXYLASE-RXN · not reversible

hydrogen carbonate pyruvate ATP
→
oxaloacetate ADP H+ phosphate
No mapped protein

RXN0-1133

EC 2.3.1.12 · R02569 · RXN0-1133 · not reversible

consuming
a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine coenzyme A
→
a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine acetyl-CoA
VK055_2451

RXN-12508

EC - · R03270 · RXN-12508 · not reversible

consuming
2-(alpha-hydroxyethyl)thiamine diphosphate a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine
→
a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine thiamine diphosphate
VK055_2293 VK055_2294 VK055_2452