Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 / 5081 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2801 VK055_3322 AAA domain family protein AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.517 No Hit 0.0% —
2802 VK055_1591 ABC transporter family protein AlphaFold + ColabFold
7.4.2.1
GO:0015424Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +36 total
0.517 Hit 53.8% 1.71e-06
2803 VK055_0832 hypothetical protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.517 No Hit 0.0% —
2804 VK055_5041 imidazole glycerol phosphate synthase, glutamineamidotransferase subunit hisH AlphaFold + ColabFold
4.3.2.10 3.5.1.2
GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.516 No Hit 0.0% —
2805 VK055_4088 periplasmic binding and sugar binding domain of LacI family protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.516 No Hit 0.0% —
2806 VK055_4035 hypothetical protein AlphaFold + ColabFold – – 0.516 No Hit 0.0% —
2807 VK055_2339 hydroxyacylglutathione hydrolase gloB AlphaFold + ColabFold
3.1.2.6
GO:0019243OBSOLETE. The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into pyruvate via the intermediate (R)-S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step. GO:0004416Catalysis of the reaction: an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H+. GO:0046872Binding to a metal ion.
0.516 Hit 36.1% 6.45e-21
2808 VK055_1689 glnH glnH AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.516 Hit 35.6% 4.60e-07
2809 VK055_0925 voltage gated chloride channel family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006821The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005247Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. +47 total
0.516 No Hit 0.0% —
2810 VK055_0150 hypothetical protein AlphaFold + ColabFold – – 0.516 No Hit 0.0% —
2811 VK055_2873 L-xylulose 5-phosphate 3-epimerase AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016861Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. GO:0034015Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate. +14 total
0.515 No Hit 0.0% —
2812 VK055_2443 S-adenosylmethionine decarboxylase proenzyme speD AlphaFold + ColabFold
4.1.1.50
GO:0008295The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. GO:0004014Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.515 No Hit 0.0% —
2813 VK055_2165 hypothetical protein AlphaFold + ColabFold – – 0.515 No Hit 0.0% —
2814 VK055_1917 plasmid stabilization system family protein AlphaFold + ColabFold – – 0.515 No Hit 0.0% —
2815 VK055_1289 hypothetical protein AlphaFold + ColabFold – – 0.515 No Hit 0.0% —
2816 VK055_0700 asp/Glu/Hydantoin racemase family protein Experimental + ColabFold –
GO:0036361OBSOLETE. Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
0.515 No Hit 0.0% —
2817 VK055_0215 glutamyl-tRNA reductase hemA AlphaFold + ColabFold
1.2.1.70
GO:0008883Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. +14 total
0.515 No Hit 0.0% —
2818 VK055_0071 holliday junction DNA helicase RuvA ruvA AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +811 total
0.515 No Hit 0.0% —
2819 VK055_5084 bacterial conjugation TrbI-like family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.514 No Hit 0.0% —
2820 VK055_2963 proP proline/betaine MFS transporter proP AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.514 No Hit 0.0% —
2821 VK055_1686 hypothetical protein AlphaFold + ColabFold – – 0.514 No Hit 0.0% —
2822 VK055_0742 hypothetical protein AlphaFold + ColabFold – – 0.514 No Hit 0.0% —
2823 VK055_0130 cell division topological specificity factor MinE minE AlphaFold + ColabFold –
GO:0032955Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0042802Binding to an identical protein or proteins.
0.514 No Hit 0.0% —
2824 VK055_5066 hypothetical protein AlphaFold + ColabFold – – 0.513 No Hit 0.0% —
2825 VK055_4444 hypothetical protein AlphaFold + ColabFold
3.2.1.78
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005515Binding to a protein. +25 total
0.513 No Hit 0.0% —
Page of 204 · 5081 total proteins