Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 / 5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2826 VK055_4095 hypothetical protein AlphaFold + ColabFold – – 0.513 No Hit 0.0% —
2827 VK055_3103 thiazole biosynthesis protein ThiH thiH AlphaFold + ColabFold
4.1.99.19
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005506Binding to an iron (Fe) ion. +36 total
0.513 No Hit 0.0% —
2828 VK055_2150 surA N-terminal domain protein AlphaFold + ColabFold –
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.513 No Hit 0.0% —
2829 VK055_2133 hypothetical protein AlphaFold + ColabFold – – 0.513 No Hit 0.0% —
2830 VK055_0893 3-hydroxyisobutyrate dehydrogenase ygbJ ColabFold –
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.513 Hit 30.3% 1.33e-11
2831 VK055_0323 cysteine desulfurase sufS AlphaFold + ColabFold –
GO:0006534OBSOLETE. The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. +14 total
0.513 Hit 32.1% 5.17e-07
2832 VK055_0107 yobH-like family protein ColabFold – – 0.513 No Hit 0.0% —
2833 VK055_4315 BMC domain protein AlphaFold + ColabFold –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
0.512 No Hit 0.0% —
2834 VK055_3960 lsrR transcriptional repressor AlphaFold + ColabFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
0.512 No Hit 0.0% —
2835 VK055_1296 hypothetical protein AlphaFold + ColabFold – – 0.512 No Hit 0.0% —
2836 VK055_1204 putative alcohol dehydrogenase zinc-binding domain protein ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.512 Hit 36.1% 9.70e-11
2837 VK055_0313 efflux transporter, RND family, MFP subunit AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.512 No Hit 0.0% —
2838 VK055_4102 peptidase MA superfamily protein AlphaFold + ColabFold – – 0.511 No Hit 0.0% —
2839 VK055_3726 hypothetical protein AlphaFold + ColabFold – – 0.511 No Hit 0.0% —
2840 VK055_3577 bacterial cellulose synthase subunit AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006011The chemical reactions and pathways involving UDP-alpha-D-glucose, a substance composed of alpha-D-glucose in glycosidic linkage with uridine diphosphate. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.511 No Hit 0.0% —
2841 VK055_2792 putative transmembrane possibly involved in transport conserved inner membrane protein Experimental + AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.511 No Hit 0.0% —
2842 VK055_2425 poly(A) polymerase I pcnB AlphaFold + ColabFold
2.7.7.19
GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003723Binding to an RNA molecule or a portion thereof. GO:1990817Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. +58 total
0.511 Hit 43.1% 5.64e-06
2843 VK055_1745 acyltransferase family protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016413Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. +14 total
0.511 No Hit 0.0% —
2844 VK055_0974 electron transport regulator A etrA AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +58 total
0.511 No Hit 0.0% —
2845 VK055_3199 ATP-dependent DNA helicase Rep rep AlphaFold + ColabFold
5.6.2.4
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006268OBSOLETE. The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +1013 total
0.51 No Hit 0.0% —
2846 VK055_3052 malF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990060Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK. +25 total
0.51 No Hit 0.0% —
2847 VK055_2732 hypothetical protein AlphaFold + ColabFold – – 0.51 No Hit 0.0% —
2848 VK055_2562 ubiquinol-cytochrome C chaperone family protein AlphaFold + ColabFold – – 0.51 No Hit 0.0% —
2849 VK055_0747 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 family protein AlphaFold + ColabFold
2.7.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
0.51 No Hit 0.0% —
2850 VK055_4684 polyphosphate kinase 1 ppk1 AlphaFold + ColabFold
2.7.4.1
GO:0008976Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). GO:0006799The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.509 No Hit 0.0% —
Page of 204 · 5081 total proteins