Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3701 VK055_0380 CRISPR type I-E/ECOLI-associated protein CasA/Cse1 casA AlphaFold + ColabFold – – 0.359 No Hit 0.0% —
3702 VK055_5033 glycosyl transferase 8 family protein Experimental + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0046872Binding to a metal ion.
0.358 Hit 22.6% 1.67e-07
3703 VK055_4902 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.358 No Hit 0.0% —
3704 VK055_3922 phosphoheptose isomerase gmhA2 AlphaFold + ColabFold –
GO:0097367Binding to a carbohydrate derivative. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. +14 total
0.358 No Hit 0.0% —
3705 VK055_2079 hypothetical protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.358 No Hit 0.0% —
3706 VK055_0189 sel1 repeat family protein AlphaFold + ColabFold –
GO:0005515Binding to a protein.
0.358 No Hit 0.0% —
3707 VK055_4642 fe-S protein assembly co-chaperone hscB AlphaFold + ColabFold –
GO:0001671Binds to and increases the activity of an ATP hydrolysis activity. GO:0044571The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. GO:0051087Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. +36 total
0.357 Hit 40.3% 8.01e-09
3708 VK055_4598 uracil-DNA glycosylase ung AlphaFold + ColabFold
3.2.2.27
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0016799Catalysis of the hydrolysis of any N-glycosyl bond. GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. +36 total
0.357 Hit 64.8% 1.46e-72
3709 VK055_1695 hypothetical protein AlphaFold + ColabFold – – 0.357 No Hit 0.0% —
3710 VK055_1694 flavin reductase like domain protein AlphaFold + ColabFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016646Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.
0.357 No Hit 0.0% —
3711 VK055_0902 hsp20/alpha crystallin family protein AlphaFold + ColabFold – – 0.357 No Hit 0.0% —
3712 VK055_0535 putative transferase AlphaFold + ColabFold –
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
0.357 No Hit 0.0% —
3713 VK055_4986 HAD hydrolase, IA, variant 1 family protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.356 No Hit 0.0% —
3714 VK055_4719 phosphate acetyltransferase pta AlphaFold + ColabFold –
GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
0.356 No Hit 0.0% —
3715 VK055_4436 periplasmic solute binding family protein AlphaFold + ColabFold –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0046872Binding to a metal ion. +14 total
0.356 No Hit 0.0% —
3716 VK055_4367 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family protein AlphaFold + ColabFold –
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
0.356 No Hit 0.0% —
3717 VK055_2320 glycerophosphoryl diester phosphodiesterase family protein AlphaFold + ColabFold –
GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0008081Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
0.356 Hit 39.4% 4.49e-11
3718 VK055_2285 transcriptional regulatory, C terminal family protein AlphaFold + ColabFold –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.356 No Hit 0.0% —
3719 VK055_1937 hypothetical protein AlphaFold + ColabFold – – 0.355 No Hit 0.0% —
3720 VK055_1494 methylglyoxal synthase mgsA AlphaFold + ColabFold
4.2.3.3
GO:0019242The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. GO:0008929Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.355 No Hit 0.0% —
3721 VK055_1229 smpA / OmlA family protein AlphaFold + ColabFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
0.355 No Hit 0.0% —
3722 VK055_0179 hypothetical protein AlphaFold + ColabFold – – 0.355 No Hit 0.0% —
3723 VK055_0031 hypothetical protein AlphaFold + ColabFold – – 0.355 No Hit 0.0% —
3724 VK055_4873 ribonucleoside-diphosphate reductase, alpha subunit AlphaFold + ColabFold
1.17.4.1
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0004748Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. +25 total
0.354 Hit 27.6% 6.44e-51
3725 VK055_1300 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
0.353 No Hit 0.0% —
Page of 204 · 5081 total proteins