Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3751 VK055_0290 vitamin B12 import ATP-binding protein BtuD btuD AlphaFold DB model + ColabFold model
7.6.2.8
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015889The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.229 0.823 Hit 29.8% 1.69e-06
3752 VK055_3986 hdeA/HdeB family protein ColabFold model –
GO:0009268Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. GO:0051082Binding to an unfolded protein.
No map N/A 0.228 No Hit 0.0% —
3753 VK055_2992 cation/acetate symporter ActP actP AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043879Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA). GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +69 total
No map 0.228 0.766 Hit 26.2% 1.58e-07
3754 VK055_0547 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.228 No Hit 0.0% —
3755 VK055_3105 diguanylate cyclase domain protein AlphaFold DB model + ColabFold model
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate.
Chokepoint 1 0.227 0.785 No Hit 0.0% —
3756 VK055_0418 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
No map 0.227 0.102 No Hit 0.0% —
3757 VK055_0212 ribose-phosphate diphosphokinase prsA AlphaFold DB model + ColabFold model
2.7.6.1
GO:0004749Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+. GO:0044249OBSOLETE. The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. GO:0009165The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). +811 total
Mapped 4 0.227 0.325 Hit 59.3% 2.18e-19
3758 VK055_5046 putative epimerase, with NAD(P)-binding Rossmann-fold domain AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004029Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.
No map 0.226 0.563 No Hit 0.0% —
3759 VK055_4752 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.226 No Hit 0.0% —
3760 VK055_2907 ribosome small subunit-dependent GTPase A rsgA AlphaFold DB model + ColabFold model
3.6.1.-
GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
Mapped 2 0.226 0.703 No Hit 0.0% —
3761 VK055_1572 specificity factor for ClpA-ClpP chaperone-protease complex clpS ColabFold model –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0030163The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
No map N/A 0.226 No Hit 0.0% —
3762 VK055_1316 ACT domain protein AlphaFold DB model + ColabFold model – – No map 0.226 0.135 No Hit 0.0% —
3763 VK055_1137 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.226 No Hit 0.0% —
3764 VK055_4446 fhlA transcriptional activator AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. +47 total
No map 0.225 0.461 No Hit 0.0% —
3765 VK055_3645 4-aminobutyrate transaminase gabT2 Experimental + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009448The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +47 total
Mapped 1 0.225 0.076 Hit 33.1% 2.79e-15
3766 VK055_3162 magnesium and cobalt transport protein CorA corA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015693The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015095Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. +710 total
No map 0.225 0.763 No Hit 0.0% —
3767 VK055_1096 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.225 0.301 No Hit 0.0% —
3768 VK055_0513 electron transport complex, RnfABCDGE type, B subunit AlphaFold DB model + ColabFold model
7.-.-.-
GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. +36 total
No map 0.225 0.369 No Hit 0.0% —
3769 VK055_0445 helix-turn-helix domain, rpiR family protein AlphaFold DB model + ColabFold model –
GO:0097367Binding to a carbohydrate derivative. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.225 0.912 No Hit 0.0% —
3770 VK055_0005 phage tail family protein ColabFold model – – No map 0.225 0.637 No Hit 0.0% —
3771 VK055_2711 merR regulatory family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.224 0.043 No Hit 0.0% —
3772 VK055_1758 molybdate ABC transporter, permease protein modB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. GO:0015098Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid. +25 total
No map 0.224 0.838 No Hit 0.0% —
3773 VK055_0555 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.224 0.845 No Hit 0.0% —
3774 VK055_5100 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.223 0.425 No Hit 0.0% —
3775 VK055_1161 sapF sapF AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.223 0.201 Hit 33.3% 1.48e-06
Page of 204 · 5081 total proteins