Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3726 VK055_0842 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.235 No Hit 0.0% —
3727 VK055_3758 ribosomal protein L2 rplB AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0015934The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). +69 total
No map 0.234 0.582 Hit 42.2% 9.19e-23
3728 VK055_2795 DNA polymerase III chi subunit, HolC family protein AlphaFold DB model + ColabFold model –
GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. +14 total
No map 0.234 0.143 No Hit 0.0% —
3729 VK055_2429 aspartate 1-decarboxylase panD AlphaFold DB model + ColabFold model
4.1.1.11
GO:0004068Catalysis of the reaction: L-aspartate = beta-alanine + CO2. GO:0006523The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
Mapped 1 N/A 0.234 No Hit 0.0% —
3730 VK055_2141 ABC transporter family protein AlphaFold DB model + ColabFold model
7.6.2.2
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +58 total
No map 0.234 0.75 Hit 50.0% 8.14e-15
3731 VK055_1603 potG AlphaFold DB model + ColabFold model
7.6.2.11
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015417Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in). +58 total
No map 0.234 0.293 Hit 34.7% 3.43e-24
3732 VK055_2408 type II secretion system protein D gspD Experimental + AlphaFold DB model + ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. +36 total
No map 0.233 0.395 No Hit 0.0% —
3733 VK055_1805 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.233 0.989 No Hit 0.0% —
3734 VK055_1743 efflux transporter, RND family, MFP subunit AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map N/A 0.233 No Hit 0.0% —
3735 VK055_4458 hydrogenase 3 and formate hydrogenlyase complex,HycG subunit AlphaFold DB model + ColabFold model –
GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +25 total
Mapped 2 0.232 0.429 Hit 37.1% 9.65e-28
3736 VK055_1180 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.232 No Hit 0.0% —
3737 VK055_4919 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.231 No Hit 0.0% —
3738 VK055_4583 23S rRNA pseudouridine synthase AlphaFold DB model + ColabFold model
5.4.99.-
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. +36 total
Mapped 1 0.231 0.433 Hit 43.4% 4.06e-06
3739 VK055_3982 glycerol dehydrase beta subunit gldB Experimental + ColabFold model
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
Chokepoint 1 0.231 0.803 No Hit 0.0% —
3740 VK055_3276 helix-turn-helix family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.231 0.28 No Hit 0.0% —
3741 VK055_2124 hypothetical protein ColabFold model – – No map N/A 0.231 No Hit 0.0% —
3742 VK055_0516 hemolysin expression modulating family protein AlphaFold DB model + ColabFold model – – No map N/A 0.231 No Hit 0.0% —
3743 VK055_0154 meiotically up-regulated gene 113 family protein ColabFold model – – No map 0.231 0.282 No Hit 0.0% —
3744 VK055_4932 GTP cyclohydrolase I folE AlphaFold DB model + ColabFold model
3.5.4.16
GO:0046654The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. GO:0003934Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
Chokepoint 1 0.230 0.425 Hit 36.0% 2.62e-34
3745 VK055_4647 sseB family protein AlphaFold DB model + ColabFold model – – No map 0.230 0.528 No Hit 0.0% —
3746 VK055_3641 cell division ATP-binding protein FtsE ftsE AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +25 total
No map 0.229 0.485 Hit 34.2% 7.25e-25
3747 VK055_2316 gpt gpt AlphaFold DB model + ColabFold model
2.4.2.22
GO:0000310Catalysis of the reaction: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
No map 0.229 0.257 No Hit 0.0% —
3748 VK055_2223 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.229 No Hit 0.0% —
3749 VK055_1742 universal stress protein UP12 AlphaFold DB model + ColabFold model – – No map 0.229 0.406 No Hit 0.0% —
3750 VK055_0393 heme ABC exporter, ATP-binding protein CcmA ccmA AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +14 total
No map 0.229 0.111 Hit 32.9% 3.65e-12
Page of 204 · 5081 total proteins