Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3776 VK055_0193 putative sel1-like repeat; harboring protein ColabFold model – – No map N/A 0.223 No Hit 0.0% —
3777 VK055_0180 AIG2-like family protein AlphaFold DB model + ColabFold model – – No map 0.223 0.442 No Hit 0.0% —
3778 VK055_0041 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.223 0.542 No Hit 0.0% —
3779 VK055_4686 phosphoribosylformylglycinamidine cyclo-ligase purM AlphaFold DB model + ColabFold model –
GO:0004641Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
Chokepoint 1 0.222 0.456 Hit 49.4% 2.47e-106
3780 VK055_4049 tonB system transport protein ExbD exbD AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map N/A 0.222 No Hit 0.0% —
3781 VK055_3525 mannitol operon repressor AlphaFold DB model + ColabFold model –
GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
No map N/A 0.222 No Hit 0.0% —
3782 VK055_3198 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.222 0.842 No Hit 0.0% —
3783 VK055_1417 putative membrane protein AlphaFold DB model + ColabFold model – – No map 0.222 0.478 No Hit 0.0% —
3784 VK055_4849 NADH:ubiquinone oxidoreductase, membrane subunitN nuoN AlphaFold DB model + ColabFold model
7.1.1.-
GO:0042773The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. +36 total
Mapped 3 0.221 0.953 Hit 21.9% 7.77e-12
3785 VK055_2894 RNA chaperone Hfq hfq AlphaFold DB model + ColabFold model –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map N/A 0.221 No Hit 0.0% —
3786 VK055_1492 hemimethylated DNA binding domain protein AlphaFold DB model + ColabFold model –
GO:0009408Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map N/A 0.221 No Hit 0.0% —
3787 VK055_1113 anti-anti-sigma factor family protein AlphaFold DB model + ColabFold model –
GO:0043856The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map N/A 0.221 No Hit 0.0% —
3788 VK055_4318 propanediol dehydratase small subunit pduE AlphaFold DB model + ColabFold model – – Chokepoint 2 0.220 0.604 No Hit 0.0% —
3789 VK055_2360 nlpE N-terminal domain protein AlphaFold DB model + ColabFold model – – No map 0.220 0.436 No Hit 0.0% —
3790 VK055_0334 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.220 0.407 Hit 32.9% 3.65e-09
3791 VK055_4949 conserved inner membrane protein yohD AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.219 0.409 No Hit 0.0% —
3792 VK055_3616 nickel import ATP-binding protein NikE nikE3 AlphaFold DB model + ColabFold model
7.2.2.11
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015413Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
No map 0.219 0.459 Hit 32.2% 5.41e-14
3793 VK055_2140 ABC transporter family protein AlphaFold DB model + ColabFold model
7.6.2.2
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +58 total
No map 0.219 0.71 Hit 54.3% 6.18e-22
3794 VK055_1930 ferric vibriobactin ABC transporter, ATP-bindingprotein fepC AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.219 0.178 Hit 32.0% 4.68e-15
3795 VK055_0197 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.219 0.589 No Hit 0.0% —
3796 VK055_4622 response regulator yfhA AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +36 total
No map 0.218 0.25 No Hit 0.0% —
3797 VK055_4482 ABC 3 transport family protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.218 0.871 No Hit 0.0% —
3798 VK055_3569 dppB dppB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.218 0.851 No Hit 0.0% —
3799 VK055_2870 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.218 No Hit 0.0% —
3800 VK055_0389 glyoxalase/Bleomycin resistance /Dioxygenase superfamily protein AlphaFold DB model + ColabFold model – – No map 0.218 0.592 No Hit 0.0% —
Page of 204 · 5081 total proteins