Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3776 VK055_3164 FMN phosphatase yigB AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
0.344 Hit 24.7% 5.27e-11
3777 VK055_1702 transketolase, thiamine diphosphate binding domain protein AlphaFold + ColabFold – – 0.344 Hit 37.5% 3.00e-15
3778 VK055_1666 iaaA AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.344 Hit 41.2% 4.93e-21
3779 VK055_1410 putative hydrolase ycdX AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.344 No Hit 0.0% —
3780 VK055_1297 L-asparaginase lanS AlphaFold + ColabFold –
GO:0006528The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid. GO:0004067Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH4+. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
0.344 No Hit 0.0% —
3781 VK055_1253 acid phosphatase pho AlphaFold + ColabFold
3.1.3.2
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0003993Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.
0.344 No Hit 0.0% —
3782 VK055_4819 acetyltransferase family protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.343 No Hit 0.0% —
3783 VK055_3203 threonine ammonia-lyase, biosynthetic ilvA AlphaFold + ColabFold
4.3.1.19
GO:0004794Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0009097OBSOLETE. The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. +47 total
0.343 Hit 51.6% 1.68e-14
3784 VK055_2987 sel1 repeat family protein Experimental + ColabFold –
GO:0005515Binding to a protein.
0.343 No Hit 0.0% —
3785 VK055_1628 hypothetical protein AlphaFold + ColabFold – – 0.343 No Hit 0.0% —
3786 VK055_1579 hypothetical protein AlphaFold + ColabFold –
GO:0015661Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane. GO:1903401The directed movement of L-lysine across a membrane.
0.343 No Hit 0.0% —
3787 VK055_0780 thioredoxin trxA AlphaFold + ColabFold –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
0.343 Hit 37.1% 4.84e-15
3788 VK055_2924 hypothetical protein AlphaFold + ColabFold – – 0.342 No Hit 0.0% —
3789 VK055_1722 hypothetical protein AlphaFold + ColabFold –
GO:0043743Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008360Any process that modulates the surface configuration of a cell.
0.342 No Hit 0.0% —
3790 VK055_1675 glycosyl hydrolases 31 family protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +14 total
0.342 Hit 30.2% 2.14e-80
3791 VK055_1483 glycogen phosphorylase, brain form pygB AlphaFold + ColabFold
2.4.1.1
GO:0008184Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004645Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. +36 total
0.342 Hit 47.8% 5.68e-65
3792 VK055_3707 hypothetical protein ColabFold – – 0.341 No Hit 0.0% —
3793 VK055_2611 siderophore-iron reductase FhuF fhuF AlphaFold + ColabFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.341 No Hit 0.0% —
3794 VK055_1103 type IV/VI secretion system, DotU family domain protein AlphaFold + ColabFold – – 0.341 No Hit 0.0% —
3795 VK055_0880 periplasmic binding domain protein AlphaFold + ColabFold –
GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.341 No Hit 0.0% —
3796 VK055_0353 NMT1-like family protein AlphaFold + ColabFold – – 0.341 No Hit 0.0% —
3797 VK055_4562 DNA repair protein RecN recN AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +25 total
0.34 No Hit 0.0% —
3798 VK055_3837 L-tartrate dehydratase, &alpha subunit AlphaFold + ColabFold
4.2.1.32
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0008730Catalysis of the reaction: L-tartrate = H2O + oxaloacetate. +14 total
0.34 No Hit 0.0% —
3799 VK055_2973 phosphonate metabolism protein PhnM phnM AlphaFold + ColabFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0019700The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.
0.34 No Hit 0.0% —
3800 VK055_2078 chaperone and weak protein oxidoreductase AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. GO:0006950Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
0.34 Hit 36.5% 6.85e-07
Page of 204 · 5081 total proteins