Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3826 VK055_0909 peptidase M3 family protein AlphaFold + ColabFold
3.4.15.5
GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +58 total
0.336 Hit 34.7% 4.37e-24
3827 VK055_3247 hypothetical protein AlphaFold + ColabFold – – 0.335 No Hit 0.0% —
3828 VK055_2896 mutL mutL AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006298A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. GO:0030983Binding to a double-stranded DNA region containing one or more mismatches. +36 total
0.335 Hit 47.4% 7.22e-09
3829 VK055_2496 leuD leuD AlphaFold + ColabFold
4.2.1.33
GO:0009316A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. GO:0009098The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid. GO:0003861Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. +14 total
0.335 No Hit 0.0% —
3830 VK055_1713 endonuclease/Exonuclease/phosphatase family protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.335 No Hit 0.0% —
3831 VK055_4670 hypothetical protein ColabFold – – 0.334 No Hit 0.0% —
3832 VK055_4595 DTW domain protein AlphaFold + ColabFold
2.5.1.25
GO:0016432Catalysis of the reaction: a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H+. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
0.334 No Hit 0.0% —
3833 VK055_1817 kdpD, KdpD-Phis AlphaFold + ColabFold
2.7.13.3
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515Binding to a protein. +912 total
0.334 No Hit 0.0% —
3834 VK055_0882 rhodanese-like domain protein AlphaFold + ColabFold – – 0.334 No Hit 0.0% —
3835 VK055_3654 livF AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +58 total
0.333 Hit 33.6% 4.55e-24
3836 VK055_3553 hypothetical protein AlphaFold + ColabFold – – 0.333 No Hit 0.0% —
3837 VK055_3287 ribbon-helix-helix, copG family protein Experimental + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
0.333 No Hit 0.0% —
3838 VK055_2531 general stress protein 14 ywrO AlphaFold + ColabFold
1.6.5.2
GO:0006813The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. +47 total
0.333 Hit 52.3% 2.23e-10
3839 VK055_1726 excinuclease ABC subunit B uvrB AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009380Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +811 total
0.333 Hit 33.0% 6.73e-06
3840 VK055_1367 putative metallodependent hydrolase AlphaFold + ColabFold –
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0004536Catalysis of the cleavage of ester linkages within deoxyribonucleic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.333 Hit 35.2% 1.77e-19
3841 VK055_3945 conserved inner membrane protein yqjA ColabFold – – 0.332 No Hit 0.0% —
3842 VK055_3192 transcription termination factor Rho rho AlphaFold + ColabFold
3.6.4.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008186Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. GO:0003676Binding to a nucleic acid. +69 total
0.332 No Hit 0.0% —
3843 VK055_2383 ribosomal protein S2 rpsB AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +25 total
0.332 Hit 30.3% 1.49e-22
3844 VK055_2144 HMP-PP phosphatase cof AlphaFold + ColabFold
3.6.1.-
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0002145Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H+. +25 total
0.332 No Hit 0.0% —
3845 VK055_2961 family 4 glycosyl hydrolase C-terminal domain protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
0.331 No Hit 0.0% —
3846 VK055_0889 recF/RecN/SMC N terminal domain protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0000731Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. +14 total
0.331 No Hit 0.0% —
3847 VK055_0877 urea ABC transporter, ATP-binding protein UrtD urtD AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.331 Hit 32.2% 1.03e-20
3848 VK055_0857 bacterial regulatory helix-turn-helix, lysR family protein Experimental + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.331 No Hit 0.0% —
3849 VK055_0322 feS assembly protein SufD sufD AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
0.331 No Hit 0.0% —
3850 VK055_4096 bacterial regulatory, luxR family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.33 No Hit 0.0% —
Page of 204 · 5081 total proteins