Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3826 VK055_4812 3-octaprenyl-4-hydroxybenzoate decarboxylase together with UbiG ubiX2 AlphaFold DB model + ColabFold model
2.5.1.129
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0106141Catalysis of the reaction: dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2.
No map 0.212 0.558 No Hit 0.0% —
3827 VK055_4220 putative outer membrane factor of efflux pump AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. +25 total
No map 0.212 0.695 No Hit 0.0% —
3828 VK055_3872 mlaF yrbF AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006869The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
No map 0.212 0.7 Hit 33.3% 5.19e-09
3829 VK055_3434 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
No map 0.212 0.66 No Hit 0.0% —
3830 VK055_2979 branched-chain amino acid transport system / permease component family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.212 0.731 No Hit 0.0% —
3831 VK055_2841 ytfT AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.212 0.443 No Hit 0.0% —
3832 VK055_1167 putative amidase/amidotransferase AlphaFold DB model + ColabFold model – – Chokepoint 8 0.212 0.737 No Hit 0.0% —
3833 VK055_0911 putative DNA-binding transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.212 0.684 No Hit 0.0% —
3834 VK055_0319 feS assembly scaffold SufA sufA AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map N/A 0.212 Hit 37.7% 9.33e-25
3835 VK055_4876 thiolase, C-terminal domain protein ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
No map 0.211 0.661 Hit 58.3% 4.13e-60
3836 VK055_4734 acetyltransferase family protein AlphaFold DB model + ColabFold model
2.3.1.-
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.211 0.055 Hit 35.5% 1.40e-07
3837 VK055_4704 phospholipase/Carboxylesterase family protein AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.211 0.089 No Hit 0.0% —
3838 VK055_1169 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.211 0.708 No Hit 0.0% —
3839 VK055_4883 rcsB rcsB AlphaFold DB model + ColabFold model –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.210 0.409 No Hit 0.0% —
3840 VK055_1683 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.21 No Hit 0.0% —
3841 VK055_1387 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.210 0.338 No Hit 0.0% —
3842 VK055_1099 type VI secretion valine-glycine repeat protein G vgrG ColabFold model – – No map 0.210 0.424 No Hit 0.0% —
3843 VK055_0083 eda eda AlphaFold DB model + ColabFold model
4.1.2.14
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008675Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate.
No map 0.210 0.94 No Hit 0.0% —
3844 VK055_4054 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.209 0.834 No Hit 0.0% —
3845 VK055_1349 liporeleasing system, ATP-binding protein lolD AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0044873A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane. +14 total
No map 0.209 0.55 Hit 54.1% 5.74e-06
3846 VK055_4093 alanine racemase, N-terminal domain protein AlphaFold DB model + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
Mapped 1 0.208 0.873 Hit 66.7% 9.32e-06
3847 VK055_3594 putative antibiotic biosynthesis monooxygenase AlphaFold DB model + ColabFold model – – No map N/A 0.208 No Hit 0.0% —
3848 VK055_2177 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.208 0.336 Hit 36.3% 4.03e-28
3849 VK055_1795 dihydrolipoyllysine-residue succinyltransferase,E2 component of oxoglutarate dehydrogenase(succinyl-transferring) complex sucB AlphaFold DB model + ColabFold model
2.3.1.61
GO:0004149Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA. GO:0045252A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. +36 total
Chokepoint 1 0.208 0.683 Hit 58.2% 7.31e-98
3850 VK055_0051 periplasmic binding and sugar binding domain of LacI family protein AlphaFold DB model + ColabFold model –
GO:0042882The process in which L-arabinose, the L-enantiomer of arabinose, is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
No map 0.208 0.576 No Hit 0.0% —
Page of 204 · 5081 total proteins