Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3876 VK055_1617 phage tail-collar fiber family protein ColabFold model – – No map 0.201 0.948 No Hit 0.0% —
3877 VK055_1108 intracellular protease, PfpI family protein AlphaFold DB model + ColabFold model – – No map 0.201 0.4 No Hit 0.0% —
3878 VK055_0949 SIS domain protein AlphaFold DB model + ColabFold model –
GO:0046348The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. GO:0097367Binding to a carbohydrate derivative. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. +36 total
No map 0.201 0.671 No Hit 0.0% —
3879 VK055_0915 inner membrane protein ynfA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.200 0.842 No Hit 0.0% —
3880 VK055_0133 ycgL domain protein AlphaFold DB model + ColabFold model – – No map N/A 0.2 No Hit 0.0% —
3881 VK055_4775 protein mrkE mrkE AlphaFold DB model + ColabFold model –
GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +14 total
No map 0.199 0.256 No Hit 0.0% —
3882 VK055_4072 gram-negative pili assembly chaperone, C-terminal domain protein AlphaFold DB model + ColabFold model –
GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +14 total
No map 0.199 0.346 No Hit 0.0% —
3883 VK055_2367 acetyl-CoA carboxylase, carboxyl transferase, alpha subunit accA AlphaFold DB model + ColabFold model
2.1.3.15
GO:0016743Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). GO:0009317A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. +47 total
Chokepoint 3 0.199 0.968 Hit 28.8% 3.73e-08
3884 VK055_2290 fimbrial subunit type 1 fim ColabFold model –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
No map 0.199 0.329 No Hit 0.0% —
3885 VK055_1149 phage shock protein B pspB AlphaFold DB model + ColabFold model –
GO:0009271A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map N/A 0.199 No Hit 0.0% —
3886 VK055_0090 copC domain protein ColabFold model –
GO:0005507Binding to a copper (Cu) ion. GO:0006825The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0046688Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. +14 total
No map N/A 0.199 No Hit 0.0% —
3887 VK055_5172 phage portal protein, HK97 family AlphaFold DB model + ColabFold model – – No map 0.198 0.85 No Hit 0.0% —
3888 VK055_4405 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.198 0.8 No Hit 0.0% —
3889 VK055_2102 hypothetical protein AlphaFold DB model + ColabFold model –
GO:1990238Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.198 0.589 No Hit 0.0% —
3890 VK055_0853 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.198 0.63 No Hit 0.0% —
3891 VK055_0070 crossover junction endodeoxyribonuclease RuvC ruvC AlphaFold DB model + ColabFold model
3.1.21.10
GO:0003676Binding to a nucleic acid. GO:0008821Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). GO:0004520Catalysis of the cleavage of ester linkages within deoxyribonucleic acid by creating internal breaks. +69 total
No map 0.198 0.304 No Hit 0.0% —
3892 VK055_4505 ygaH L-valine exporter ygaH AlphaFold DB model + ColabFold model – – No map 0.197 0.997 No Hit 0.0% —
3893 VK055_3294 putative cytoplasmic protein AlphaFold DB model + ColabFold model – – No map N/A 0.197 No Hit 0.0% —
3894 VK055_2760 phage integrase family protein AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.197 0.093 No Hit 0.0% —
3895 VK055_1859 rare lipoprotein LptE ColabFold model –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No map N/A 0.197 No Hit 0.0% —
3896 VK055_3038 zur transcriptional repressor zur AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
No map 0.196 0.381 No Hit 0.0% —
3897 VK055_2478 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.196 No Hit 0.0% —
3898 VK055_4900 nudix-type nucleoside diphosphatase, YffH/AdpP family protein AlphaFold DB model + ColabFold model –
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0046872Binding to a metal ion. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.195 0.491 Hit 33.1% 1.38e-09
3899 VK055_4044 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.195 0.172 No Hit 0.0% —
3900 VK055_3575 cellulose synthase operon protein YhjQ yhjQ AlphaFold DB model + ColabFold model – – No map 0.195 0.42 No Hit 0.0% —
Page of 204 · 5081 total proteins