Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3876 VK055_1457 gamma-glutamyl-gamma-aminobutyrate hydrolase AlphaFold + ColabFold
3.5.1.94
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.324 No Hit 0.0% —
3877 VK055_4710 nudix-type nucleoside diphosphatase, YffH/AdpP family protein AlphaFold + ColabFold –
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0046872Binding to a metal ion.
0.323 Hit 32.4% 1.07e-08
3878 VK055_3955 helix-turn-helix family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.323 No Hit 0.0% —
3879 VK055_3771 ribosomal protein L18 rplR AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +25 total
0.323 Hit 39.2% 1.20e-06
3880 VK055_3637 putative membrane protein AlphaFold + ColabFold – – 0.323 No Hit 0.0% —
3881 VK055_1053 heat shock protein hslJ hslJ AlphaFold + ColabFold – – 0.323 No Hit 0.0% —
3882 VK055_0817 fimbrial family protein AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.323 No Hit 0.0% —
3883 VK055_3843 periplasmic serine peptidase DegS degS AlphaFold + ColabFold
3.4.21.107
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. +36 total
0.322 Hit 36.9% 1.45e-18
3884 VK055_1981 putative aldo/keto reductase AlphaFold + ColabFold – – 0.322 No Hit 0.0% —
3885 VK055_3530 L-seryl-tRNA selenium transferase selA AlphaFold + ColabFold
2.9.1.1
GO:0001514The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.321 No Hit 0.0% —
3886 VK055_1996 mechanosensitive ion channel family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.321 No Hit 0.0% —
3887 VK055_3819 rod shape-determining protein MreC mreC AlphaFold + ColabFold –
GO:0008360Any process that modulates the surface configuration of a cell. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.32 No Hit 0.0% —
3888 VK055_3700 heat shock protein Hsp15 involved in ribosome recycling yrfH AlphaFold + ColabFold –
GO:0003727Binding to single-stranded RNA. GO:0043023Binding to a large ribosomal subunit. GO:0003723Binding to an RNA molecule or a portion thereof. +25 total
0.32 No Hit 0.0% —
3889 VK055_2990 acetate--CoA ligase acs AlphaFold + ColabFold
6.2.1.1
GO:0003987Catalysis of the reaction: acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate. GO:0016208Binding to AMP, adenosine monophosphate. GO:0019427OBSOLETE. The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate. +47 total
0.32 Hit 52.2% 5.87e-25
3890 VK055_2965 hypothetical protein AlphaFold + ColabFold – – 0.32 No Hit 0.0% —
3891 VK055_1998 hypothetical protein ColabFold – – 0.32 No Hit 0.0% —
3892 VK055_4794 chorismate synthase aroC AlphaFold + ColabFold
4.2.3.5
GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). GO:0004107Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.319 No Hit 0.0% —
3893 VK055_3300 ribosome biogenesis GTP-binding protein YsxC ysxC Experimental + ColabFold –
GO:0005525Binding to GTP, guanosine triphosphate.
0.319 Hit 35.1% 5.93e-19
3894 VK055_2438 multicopper oxidase with role in copper homeostasis AlphaFold + ColabFold
1.16.3.4
GO:0005507Binding to a copper (Cu) ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.319 No Hit 0.0% —
3895 VK055_2359 nlpC/P60 family protein AlphaFold + ColabFold – – 0.319 No Hit 0.0% —
3896 VK055_5042 hisB AlphaFold + ColabFold –
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0004401Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate. +36 total
0.318 No Hit 0.0% —
3897 VK055_4018 glycogen synthesis family protein AlphaFold + ColabFold –
GO:1902201Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum-dependent cell motility. GO:1900191Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation.
0.318 No Hit 0.0% —
3898 VK055_3816 hypothetical protein AlphaFold + ColabFold – – 0.318 No Hit 0.0% —
3899 VK055_3767 ribosomal L5 family protein AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
0.318 Hit 32.6% 6.51e-12
3900 VK055_2707 membrane fusion protein of the CusCFBA copper efflux system AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +58 total
0.318 No Hit 0.0% —
Page of 204 · 5081 total proteins