Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3851 VK055_3839 oxaloacetate decarboxylase gamma chain oadG2 AlphaFold + ColabFold
7.2.4.2
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015081Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. GO:0036376The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. +36 total
0.33 No Hit 0.0% —
3852 VK055_3460 sulfate ABC transporter, sulfate-binding family protein AlphaFold + ColabFold –
GO:1902358The directed movement of sulfate across a membrane. GO:0140104Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. GO:1901681Binding to a sulfur compound. +14 total
0.33 No Hit 0.0% —
3853 VK055_4730 putative structural protein, ethanolamine utilization microcompartment AlphaFold + ColabFold –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
0.329 No Hit 0.0% —
3854 VK055_2290 fimbrial subunit type 1 fim ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
0.329 No Hit 0.0% —
3855 VK055_1759 molybdate ABC transporter, periplasmic molybdate-binding protein modA Experimental + ColabFold –
GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0046872Binding to a metal ion. +25 total
0.329 No Hit 0.0% —
3856 VK055_0307 ABC transporter family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.329 Hit 36.2% 6.53e-07
3857 VK055_0285 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.329 No Hit 0.0% —
3858 VK055_0061 copper homeostasis protein cutC AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005507Binding to a copper (Cu) ion.
0.329 Hit 50.3% 5.62e-48
3859 VK055_2844 ppa ppa2 AlphaFold + ColabFold
3.6.1.1
GO:0004427Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate. GO:0006796The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.328 No Hit 0.0% —
3860 VK055_2096 DNA-binding protein, YbaB/EbfC family AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.328 No Hit 0.0% —
3861 VK055_0850 altronate oxidoreductase uxaB AlphaFold + ColabFold
1.1.1.58
GO:0009026Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + H+ + NADH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.328 No Hit 0.0% —
3862 VK055_0730 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.328 No Hit 0.0% —
3863 VK055_3345 phosphate ABC transporter, ATP-binding protein pstB AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005315Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. +36 total
0.327 Hit 33.9% 2.20e-23
3864 VK055_3323 VWA domain containing CoxE-like family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.327 No Hit 0.0% —
3865 VK055_2288 type VII secretion system (T7SS), usher family protein AlphaFold + ColabFold –
GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515Binding to a protein. +25 total
0.327 No Hit 0.0% —
3866 VK055_1874 carbon-nitrogen hydrolase family protein AlphaFold + ColabFold –
GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
0.327 Hit 35.5% 7.99e-40
3867 VK055_0849 acetyltransferase family protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
0.327 Hit 27.7% 2.88e-06
3868 VK055_1119 hypothetical protein AlphaFold + ColabFold – – 0.326 No Hit 0.0% —
3869 VK055_3153 sugar phosphatase Experimental + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.325 No Hit 0.0% —
3870 VK055_2783 hypothetical protein ColabFold – – 0.325 No Hit 0.0% —
3871 VK055_2515 DNA polymerase II AlphaFold + ColabFold
2.7.7.7
GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0003676Binding to a nucleic acid. +47 total
0.325 Hit 27.6% 1.95e-08
3872 VK055_0919 hypothetical protein AlphaFold + ColabFold – – 0.325 No Hit 0.0% —
3873 VK055_0403 oxidoreductase, aldo/keto reductase family AlphaFold + ColabFold
1.1.1.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
0.325 Hit 46.6% 6.84e-12
3874 VK055_0212 ribose-phosphate diphosphokinase prsA AlphaFold + ColabFold
2.7.6.1
GO:0004749Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+. GO:0044249OBSOLETE. The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. GO:0009165The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). +811 total
0.325 Hit 59.3% 2.18e-19
3875 VK055_4931 S-formylglutathione hydrolase fghA AlphaFold + ColabFold
3.1.2.12
GO:0046294The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. GO:0018738Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.324 Hit 54.0% 4.83e-94
Page of 204 · 5081 total proteins