Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4051 VK055_2388 cdaR transcriptional activator cdaR AlphaFold + ColabFold – – 0.293 No Hit 0.0% —
4052 VK055_1603 potG AlphaFold + ColabFold
7.6.2.11
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015417Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in). +58 total
0.293 Hit 34.7% 3.43e-24
4053 VK055_1017 hypothetical protein ColabFold – – 0.293 No Hit 0.0% —
4054 VK055_4100 ribosomal RNA small subunit methyltransferase E rsmE AlphaFold + ColabFold
2.1.1.193
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.292 No Hit 0.0% —
4055 VK055_3961 heme ABC exporter, ATP-binding protein CcmA ccmA13 AlphaFold + ColabFold
7.6.2.13
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.292 Hit 35.7% 2.52e-10
4056 VK055_3223 hypothetical protein AlphaFold + ColabFold – – 0.292 No Hit 0.0% —
4057 VK055_2947 hypothetical protein AlphaFold + ColabFold – – 0.292 No Hit 0.0% —
4058 VK055_1657 putative glutathione S-transferase AlphaFold + ColabFold
2.5.1.18
GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+.
0.292 No Hit 0.0% —
4059 VK055_0018 DNA mismatch endonuclease of the very short patch (VSP) mismatch repair pathway AlphaFold + ColabFold
3.1.-.-
GO:0006298A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.292 No Hit 0.0% —
4060 VK055_5109 antidote-toxin recognition MazE family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.291 No Hit 0.0% —
4061 VK055_4151 putative copper-sensitivity suppressor protein A ColabFold – – 0.291 No Hit 0.0% —
4062 VK055_1058 KTSC domain protein AlphaFold + ColabFold – – 0.291 No Hit 0.0% —
4063 VK055_0272 hypothetical protein AlphaFold + ColabFold –
GO:0004521Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.
0.291 No Hit 0.0% —
4064 VK055_5045 ATP phosphoribosyltransferase hisG AlphaFold + ColabFold
2.4.2.17
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0000287Binding to a magnesium (Mg) ion. GO:0003879Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. +25 total
0.29 No Hit 0.0% —
4065 VK055_4663 exodeoxyribonuclease VII, large subunit xseA AlphaFold + ColabFold
3.1.11.6
GO:0003676Binding to a nucleic acid. GO:0009318An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA. GO:0006308The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. +25 total
0.29 No Hit 0.0% —
4066 VK055_3072 zinc-binding dehydrogenase family protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.29 Hit 24.7% 1.50e-09
4067 VK055_2825 cys/Met metabolism PLP-dependent enzyme family protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004125Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate.
0.29 No Hit 0.0% —
4068 VK055_2631 putative PTS permease Experimental + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.29 No Hit 0.0% —
4069 VK055_2280 proB proB AlphaFold + ColabFold
2.7.2.11
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006561OBSOLETE. The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. +58 total
0.29 Hit 33.4% 3.33e-32
4070 VK055_1809 allophanate hydrolase subunit 1 family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.29 No Hit 0.0% —
4071 VK055_1220 cell division modulator cedA AlphaFold + ColabFold –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.29 No Hit 0.0% —
4072 VK055_1111 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.29 No Hit 0.0% —
4073 VK055_0076 putative peptidase AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +14 total
0.29 No Hit 0.0% —
4074 VK055_4219 putative cytoplasmic protein ColabFold – – 0.289 No Hit 0.0% —
4075 VK055_4071 gram-negative pili assembly chaperone, C-terminal domain protein ColabFold – – 0.289 No Hit 0.0% —
Page of 204 · 5081 total proteins