Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4051 VK055_2953 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.163 No Hit 0.0% —
4052 VK055_2883 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.163 No Hit 0.0% —
4053 VK055_2832 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.163 No Hit 0.0% —
4054 VK055_2508 inner membrane protein yabI yabI AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.163 0.833 No Hit 0.0% —
4055 VK055_5000 efflux transporter, RND family, MFP subunit AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map N/A 0.162 No Hit 0.0% —
4056 VK055_2830 glycine-rich SFCGS family protein AlphaFold DB model + ColabFold model – – No map N/A 0.162 No Hit 0.0% —
4057 VK055_2705 outer membrane factor of the CusCFBA copper/silver efflux system AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. +25 total
No map 0.162 0.713 No Hit 0.0% —
4058 VK055_2562 ubiquinol-cytochrome C chaperone family protein AlphaFold DB model + ColabFold model – – No map 0.162 0.51 No Hit 0.0% —
4059 VK055_1558 dimethylsulfoxide reductase, chain B dmsB2 AlphaFold DB model + ColabFold model –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
No map 0.162 0.528 No Hit 0.0% —
4060 VK055_1449 yccJ-like family protein AlphaFold DB model + ColabFold model – – No map N/A 0.162 No Hit 0.0% —
4061 VK055_1094 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.162 0.96 No Hit 0.0% —
4062 VK055_0556 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.162 0.999 No Hit 0.0% —
4063 VK055_0155 hypothetical protein ColabFold model – – No map 0.162 0.608 No Hit 0.0% —
4064 VK055_1689 glnH glnH AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
No map 0.161 0.516 Hit 35.6% 4.60e-07
4065 VK055_0576 amino acid permease family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.161 0.278 Hit 23.6% 6.68e-07
4066 VK055_3417 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase ligK AlphaFold DB model + ColabFold model
4.1.3.17
GO:0047443Catalysis of the reactions: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate, and 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate. GO:0046872Binding to a metal ion. GO:0042537The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. +25 total
Mapped 3 0.160 0.231 No Hit 0.0% —
4067 VK055_3233 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.160 0.735 No Hit 0.0% —
4068 VK055_2206 fructose-1,6-bisphosphate aldolase, class II fba AlphaFold DB model + ColabFold model –
GO:0030388The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. +36 total
Mapped 4 0.160 0.946 No Hit 0.0% —
4069 VK055_1313 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.16 No Hit 0.0% —
4070 VK055_4764 mu DNA-binding domain protein AlphaFold DB model + ColabFold model – – No map 0.159 0.199 No Hit 0.0% —
4071 VK055_4693 arsenate reductase arsC2 AlphaFold DB model + ColabFold model
1.20.4.1
GO:0008794Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
Chokepoint 4 N/A 0.159 No Hit 0.0% —
4072 VK055_2989 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.159 No Hit 0.0% —
4073 VK055_2449 putative secreted protein AlphaFold DB model + ColabFold model – – No map N/A 0.159 No Hit 0.0% —
4074 VK055_1496 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.158 0.859 No Hit 0.0% —
4075 VK055_0079 helix-turn-helix domain, rpiR family protein AlphaFold DB model + ColabFold model –
GO:0097367Binding to a carbohydrate derivative. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.158 0.617 No Hit 0.0% —
Page of 204 · 5081 total proteins