Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4076 VK055_4294 exodeoxyribonuclease V, gamma subunit recC AlphaFold DB model + ColabFold model –
GO:0009338An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA. GO:0008854Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
No map 0.157 0.581 No Hit 0.0% —
4077 VK055_3628 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. +36 total
No map 0.157 0.74 No Hit 0.0% —
4078 VK055_3290 D-tyrosyl-tRNA(Tyr) deacylase dtd AlphaFold DB model + ColabFold model
3.1.1.96 3.1.1.-
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051499Catalysis of the reaction: a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H+. Removal of a D-amino acid from a charged tRNA. +58 total
No map 0.157 0.778 Hit 34.4% 1.31e-16
4079 VK055_0703 sulfite exporter TauE/SafE family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.157 0.925 No Hit 0.0% —
4080 VK055_0602 nitrate reductase, beta subunit narH2 AlphaFold DB model + ColabFold model
1.7.5.1
GO:0042126The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid. GO:0009325An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor. GO:0008940Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. +811 total
Mapped 2 0.157 0.443 No Hit 0.0% —
4081 VK055_0347 putative thiosulfate sulfurtransferase AlphaFold DB model + ColabFold model –
GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+.
Mapped 3 0.157 0.696 No Hit 0.0% —
4082 VK055_4802 putative flagellar assembly protein AlphaFold DB model + ColabFold model –
GO:0010468Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.156 0.481 No Hit 0.0% —
4083 VK055_4101 extracellular deoxyribonuclease AlphaFold DB model + ColabFold model –
GO:0004518Catalysis of the cleavage of ester linkages within nucleic acids. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.156 0.82 No Hit 0.0% —
4084 VK055_3123 biotin operon repressor Experimental + ColabFold model
6.3.4.15
GO:0004077Catalysis of the reaction: ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H+ + N(6)-biotinyl-L-lysyl-[protein]. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +36 total
No map 0.156 0.976 Hit 32.3% 1.07e-06
4085 VK055_2940 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.156 0.243 No Hit 0.0% —
4086 VK055_2355 metQ metQ2 AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015821The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.156 0.597 No Hit 0.0% —
4087 VK055_0923 DMS reductase maturation protein dmsD AlphaFold DB model + ColabFold model –
GO:0005048Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.
No map 0.156 0.346 No Hit 0.0% —
4088 VK055_0767 periplasmic binding and sugar binding domain of LacI family protein Experimental + ColabFold model – – No map 0.156 0.5 No Hit 0.0% —
4089 VK055_5032 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. +14 total
No map 0.155 0.881 Hit 33.8% 1.62e-26
4090 VK055_3455 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.155 No Hit 0.0% —
4091 VK055_2061 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.155 0.11 No Hit 0.0% —
4092 VK055_2255 branched-chain amino-acid ABC transport system ATP-binding protein livF AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +14 total
No map 0.154 0.67 Hit 29.4% 7.56e-08
4093 VK055_3131 flavodoxin family protein AlphaFold DB model + ColabFold model
1.3.5.3
GO:0006782The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0006783The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. +47 total
No map 0.153 0.918 No Hit 0.0% —
4094 VK055_2258 bacterial extracellular solute-binding, 3 familyprotein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. +25 total
No map 0.153 0.294 Hit 42.5% 2.33e-06
4095 VK055_0219 tetratricopeptide repeat family protein AlphaFold DB model + ColabFold model – – No map 0.153 0.377 No Hit 0.0% —
4096 VK055_4428 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.152 No Hit 0.0% —
4097 VK055_3517 protein-export chaperone SecB secB AlphaFold DB model + ColabFold model –
GO:0051082Binding to an unfolded protein. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0051262The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. +25 total
No map 0.152 0.834 No Hit 0.0% —
4098 VK055_2821 qin prophage antitoxin of the RelE-RelB toxin-antitoxin system and transcriptional repressor of relBEF relB AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template.
No map N/A 0.152 No Hit 0.0% —
4099 VK055_0564 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.152 No Hit 0.0% —
4100 VK055_1541 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.151 0.149 No Hit 0.0% —
Page of 204 · 5081 total proteins