Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4326 VK055_3935 pirin family protein AlphaFold + ColabFold – – 0.235 No Hit 0.0% —
4327 VK055_1992 hypothetical protein AlphaFold + ColabFold – – 0.235 No Hit 0.0% —
4328 VK055_0842 hypothetical protein AlphaFold + ColabFold – – 0.235 No Hit 0.0% —
4329 VK055_3915 GIY-YIG catalytic domain protein AlphaFold + ColabFold – – 0.234 No Hit 0.0% —
4330 VK055_2429 aspartate 1-decarboxylase panD AlphaFold + ColabFold
4.1.1.11
GO:0004068Catalysis of the reaction: L-aspartate = beta-alanine + CO2. GO:0006523The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.234 No Hit 0.0% —
4331 VK055_4887 ada transcriptional dual regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003908Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +811 total
0.233 Hit 30.7% 2.98e-15
4332 VK055_4833 deoxyribonucleoside 5'-monophosphate phosphatase yfbR AlphaFold + ColabFold
3.1.3.89
GO:0002953Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. +14 total
0.233 No Hit 0.0% —
4333 VK055_4153 helix-turn-helix domain, rpiR family protein AlphaFold + ColabFold –
GO:0097367Binding to a carbohydrate derivative. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.233 No Hit 0.0% —
4334 VK055_2183 putative oxidoreductase, NAD(P)-binding putativeNAD(P)H-dependent xylose reductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.233 Hit 38.5% 4.22e-10
4335 VK055_1743 efflux transporter, RND family, MFP subunit AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.233 No Hit 0.0% —
4336 VK055_3360 DNA polymerase III, beta subunit dnaN AlphaFold + ColabFold –
GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. +58 total
0.232 No Hit 0.0% —
4337 VK055_2534 carA carA AlphaFold + ColabFold
6.3.5.5
GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. GO:0004088Catalysis of the reaction: hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H+. GO:0006541The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. +47 total
0.232 Hit 38.9% 1.15e-69
4338 VK055_2041 heme ABC exporter, ATP-binding protein CcmA ccmA6 AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.232 Hit 40.8% 6.34e-06
4339 VK055_1180 hypothetical protein AlphaFold + ColabFold – – 0.232 No Hit 0.0% —
4340 VK055_4919 hypothetical protein AlphaFold + ColabFold – – 0.231 No Hit 0.0% —
4341 VK055_4055 glutathione S-transferase, C-terminal domain protein AlphaFold + ColabFold – – 0.231 No Hit 0.0% —
4342 VK055_3417 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase ligK AlphaFold + ColabFold
4.1.3.17
GO:0047443Catalysis of the reactions: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate, and 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate. GO:0046872Binding to a metal ion. GO:0042537The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. +25 total
0.231 No Hit 0.0% —
4343 VK055_2433 yadG yadG AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.231 Hit 39.2% 6.48e-34
4344 VK055_2124 hypothetical protein ColabFold – – 0.231 No Hit 0.0% —
4345 VK055_0516 hemolysin expression modulating family protein AlphaFold + ColabFold – – 0.231 No Hit 0.0% —
4346 VK055_0468 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.231 No Hit 0.0% —
4347 VK055_4056 hypothetical protein AlphaFold + ColabFold – – 0.23 No Hit 0.0% —
4348 VK055_3280 formate dehydrogenase family accessory protein FdhD AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.23 No Hit 0.0% —
4349 VK055_2601 pyrimidine nucleotidase AlphaFold + ColabFold –
GO:0008253Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
0.23 Hit 30.3% 6.95e-16
4350 VK055_2229 alkaline phosphatase H phoA Experimental + ColabFold
3.1.3.1
GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004035Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. +14 total
0.23 Hit 30.4% 2.10e-29
Page of 204 · 5081 total proteins