Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4301 VK055_1040 phenylacetic acid degradation B Experimental + AlphaFold + ColabFold – – 0.242 No Hit 0.0% —
4302 VK055_4893 ecotin family protein AlphaFold + ColabFold –
GO:0004867Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.241 No Hit 0.0% —
4303 VK055_4193 ureE urease accessory, N-terminal domain protein AlphaFold + ColabFold –
GO:0019627The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0065003The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. +36 total
0.241 No Hit 0.0% —
4304 VK055_3754 ribosomal protein S10 rpsJ AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +36 total
0.241 Hit 30.7% 1.59e-07
4305 VK055_2176 putative 2-dehydropantoate 2-reductase apbA AlphaFold + ColabFold
1.1.1.169
GO:0008677Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0015940The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. +25 total
0.241 No Hit 0.0% —
4306 VK055_0772 bacterial regulatory helix-turn-helix, lysR family protein ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.241 No Hit 0.0% —
4307 VK055_0397 ccmE ccmE AlphaFold + ColabFold –
GO:0017003The covalent linkage of heme and a protein. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. +25 total
0.241 No Hit 0.0% —
4308 VK055_4503 hypothetical protein AlphaFold + ColabFold – – 0.24 No Hit 0.0% —
4309 VK055_3929 2-hydroxy-3-oxopropionate reductase AlphaFold + ColabFold
1.1.1.60
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0046487The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. +36 total
0.239 Hit 36.8% 2.04e-26
4310 VK055_3442 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.239 No Hit 0.0% —
4311 VK055_3229 N-acetyl-gamma-glutamyl-phosphate reductase argC AlphaFold + ColabFold
1.2.1.38
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0006526The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +58 total
0.239 No Hit 0.0% —
4312 VK055_2948 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA pgaA AlphaFold + ColabFold –
GO:1901515Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other. GO:0005515Binding to a protein.
0.239 No Hit 0.0% —
4313 VK055_1869 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.239 No Hit 0.0% —
4314 VK055_4923 1-phosphofructokinase pfkB AlphaFold + ColabFold –
GO:0008662Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +58 total
0.238 No Hit 0.0% —
4315 VK055_4511 ribonucleoside-diphosphate reductase, alpha subunit AlphaFold + ColabFold
1.17.4.1
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0004748Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. +25 total
0.238 Hit 33.0% 5.47e-10
4316 VK055_4161 dsbCreduced dsbC AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.238 No Hit 0.0% —
4317 VK055_3445 zinc-binding alcohol dehydrogenase family protein AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.238 Hit 34.2% 6.42e-25
4318 VK055_2365 glyoxalase/Bleomycin resistance /Dioxygenase superfamily protein AlphaFold + ColabFold –
GO:0046872Binding to a metal ion.
0.238 No Hit 0.0% —
4319 VK055_1248 hypothetical protein ColabFold – – 0.238 No Hit 0.0% —
4320 VK055_0417 hypothetical protein AlphaFold + ColabFold – – 0.238 No Hit 0.0% —
4321 VK055_4898 DNA-associated protein yjeK AlphaFold + ColabFold –
GO:0009295The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.237 No Hit 0.0% —
4322 VK055_3411 PTS system, Lactose/Cellobiose specific IIB subunit AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.237 No Hit 0.0% —
4323 VK055_5092 transglycosylase SLT domain protein ColabFold – – 0.236 No Hit 0.0% —
4324 VK055_4509 proV proV AlphaFold + ColabFold
7.6.2.9
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0031460The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +58 total
0.236 Hit 44.4% 7.48e-06
4325 VK055_4357 L-fuculokinase fucK AlphaFold + ColabFold
2.7.1.51
GO:0008737Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H+. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +36 total
0.236 Hit 20.6% 3.37e-09
Page of 204 · 5081 total proteins