Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4351 VK055_4944 PRD domain protein AlphaFold + ColabFold –
GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.229 No Hit 0.0% —
4352 VK055_4373 ABC transporter, substrate-binding, aliphatic sulfonates family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.229 No Hit 0.0% —
4353 VK055_3348 esterase family protein AlphaFold + ColabFold –
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +14 total
0.229 No Hit 0.0% —
4354 VK055_2772 phosphohydrolase AlphaFold + ColabFold –
GO:0004112Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.229 No Hit 0.0% —
4355 VK055_2223 hypothetical protein AlphaFold + ColabFold – – 0.229 No Hit 0.0% —
4356 VK055_3986 hdeA/HdeB family protein ColabFold –
GO:0009268Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. GO:0051082Binding to an unfolded protein.
0.228 No Hit 0.0% —
4357 VK055_3593 ketodeoxygluconokinase kdgK AlphaFold + ColabFold
2.7.1.45
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008673Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+. +47 total
0.228 No Hit 0.0% —
4358 VK055_0547 hypothetical protein AlphaFold + ColabFold – – 0.228 No Hit 0.0% —
4359 VK055_2886 nsrR nsrR AlphaFold + ColabFold –
GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. +36 total
0.227 No Hit 0.0% —
4360 VK055_2839 fructose-1-6-bisphosphatase family protein AlphaFold + ColabFold
3.1.3.11
GO:0042578Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +811 total
0.227 Hit 48.9% 1.20e-31
4361 VK055_1260 HNH endonuclease family protein AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0003676Binding to a nucleic acid.
0.227 No Hit 0.0% —
4362 VK055_0321 feS assembly ATPase SufC sufC AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.227 Hit 31.0% 2.68e-10
4363 VK055_4752 hypothetical protein AlphaFold + ColabFold – – 0.226 No Hit 0.0% —
4364 VK055_4716 ethanolamine utilization protein, EutP eutP2 AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006576The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
0.226 No Hit 0.0% —
4365 VK055_3440 beta-lactamase superfamily domain protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.226 No Hit 0.0% —
4366 VK055_2796 valine--tRNA ligase valS AlphaFold + ColabFold
6.1.1.9
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006438The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. +69 total
0.226 Hit 50.0% 4.16e-63
4367 VK055_1572 specificity factor for ClpA-ClpP chaperone-protease complex clpS ColabFold –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0030163The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
0.226 No Hit 0.0% —
4368 VK055_1137 hypothetical protein AlphaFold + ColabFold – – 0.226 No Hit 0.0% —
4369 VK055_1020 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.226 No Hit 0.0% —
4370 VK055_0991 mannose-6-phosphate isomerase, class I manA AlphaFold + ColabFold
5.3.1.8
GO:0008270Binding to a zinc ion (Zn). GO:0009298The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. GO:0004476Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. +25 total
0.226 Hit 39.8% 1.47e-29
4371 VK055_4243 gram-negative pili assembly chaperone, C-terminal domain protein AlphaFold + ColabFold –
GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +14 total
0.225 No Hit 0.0% —
4372 VK055_4039 cell division protein sufI AlphaFold + ColabFold –
GO:0005507Binding to a copper (Cu) ion. GO:0043093A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +25 total
0.225 No Hit 0.0% —
4373 VK055_3499 glycosyl transferases group 1 family protein AlphaFold + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
0.225 No Hit 0.0% —
4374 VK055_1976 &gamma-glutamyl:cysteine ligase YbdK ybdK AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016879Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0004357Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate. +14 total
0.225 No Hit 0.0% —
4375 VK055_1130 hypothetical protein AlphaFold + ColabFold – – 0.225 No Hit 0.0% —
Page of 204 · 5081 total proteins