Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4351 VK055_3192 transcription termination factor Rho rho AlphaFold DB model + ColabFold model
3.6.4.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008186Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. GO:0003676Binding to a nucleic acid. +69 total
No map 0.093 0.332 No Hit 0.0% —
4352 VK055_1269 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.093 0.808 No Hit 0.0% —
4353 VK055_0620 ccdB family protein AlphaFold DB model + ColabFold model –
GO:0008657Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. GO:0006276The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division.
No map 0.093 0.462 No Hit 0.0% —
4354 VK055_3983 glycerol dehydrase gamma subunit dhaB3 Experimental + ColabFold model
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
Chokepoint 1 0.092 0.695 No Hit 0.0% —
4355 VK055_2926 gram-negative pili assembly chaperone, C-terminal domain protein ColabFold model – – No map 0.092 0.211 No Hit 0.0% —
4356 VK055_2640 helix-turn-helix domain, rpiR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. +14 total
No map 0.092 0.856 No Hit 0.0% —
4357 VK055_0927 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
No map 0.092 0.174 No Hit 0.0% —
4358 VK055_0509 electron transport complex, RnfABCDGE type, E subunit AlphaFold DB model + ColabFold model
7.-.-.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. +14 total
No map 0.092 0.955 No Hit 0.0% —
4359 VK055_4877 acetyl-CoA acetyltransferase thlA ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
Mapped 13 0.091 0.465 Hit 64.0% 2.22e-12
4360 VK055_4614 4Fe-4S binding domain protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
No map 0.091 0.454 No Hit 0.0% —
4361 VK055_4563 NAD kinase monomer ppnK AlphaFold DB model + ColabFold model
2.7.1.23
GO:0019674The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. GO:0006741The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide phosphate (NADP+), a coenzyme that interconverts with its reduced form, NADPH, in many redox and biosynthetic reactions. GO:0003951Catalysis of the reaction: ATP + NAD+ = ADP + H+ + NADP+. +47 total
Mapped 1 0.091 0.431 Hit 27.6% 8.65e-19
4362 VK055_4161 dsbCreduced dsbC AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.091 0.238 No Hit 0.0% —
4363 VK055_3902 translation initiation factor IF-2 infB AlphaFold DB model + ColabFold model –
GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. GO:0005525Binding to GTP, guanosine triphosphate. GO:0006413The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. +36 total
No map 0.091 0.644 Hit 41.5% 5.97e-126
4364 VK055_3803 acrA Membrane Fusion Protein acrA2 AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.091 0.913 No Hit 0.0% —
4365 VK055_2662 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.091 0.559 No Hit 0.0% —
4366 VK055_2410 type II secretion system protein F gspF AlphaFold DB model + ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. +36 total
No map 0.091 0.906 No Hit 0.0% —
4367 VK055_1972 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.091 0.724 No Hit 0.0% —
4368 VK055_1613 putative orf35 AlphaFold DB model + ColabFold model – – No map 0.091 0.844 No Hit 0.0% —
4369 VK055_1112 histidine kinase-like ATPase domain protein AlphaFold DB model + ColabFold model –
GO:0004674Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
No map 0.091 0.812 No Hit 0.0% —
4370 VK055_3433 pyridoxamine 5'-phosphate oxidase family protein AlphaFold DB model + ColabFold model – – No map 0.090 0.56 No Hit 0.0% —
4371 VK055_2501 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.090 0.655 No Hit 0.0% —
4372 VK055_0638 30S ribosomal subunit S22 family protein AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
No map N/A 0.09 No Hit 0.0% —
4373 VK055_0093 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.09 No Hit 0.0% —
4374 VK055_3011 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.089 0.872 No Hit 0.0% —
4375 VK055_2833 cytochrome b cybC AlphaFold DB model + ColabFold model –
GO:0005506Binding to an iron (Fe) ion. GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +25 total
No map 0.089 0.856 No Hit 0.0% —
Page of 204 · 5081 total proteins