Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4276 VK055_0685 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.248 No Hit 0.0% —
4277 VK055_4314 BMC domain protein AlphaFold + ColabFold –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
0.247 No Hit 0.0% —
4278 VK055_2423 RNA polymerase-binding protein DksA dksA AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0010468Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
0.247 No Hit 0.0% —
4279 VK055_4788 hypothetical protein AlphaFold + ColabFold – – 0.246 No Hit 0.0% —
4280 VK055_4555 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
0.246 No Hit 0.0% —
4281 VK055_4703 tRNAMet cytidine acetyltransferase AlphaFold + ColabFold
2.3.1.193
GO:0051392Catalysis of the reaction: a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N4-acetylcytidine in tRNA + CoA + H+ + phosphate. GO:0002101The process in which a cytosine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +710 total
0.245 Hit 23.4% 2.04e-17
4282 VK055_4341 cobalt ABC transporter, ATP-binding family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +47 total
0.245 Hit 33.9% 4.16e-13
4283 VK055_3878 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA AlphaFold + ColabFold
2.5.1.7
GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008760Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. +69 total
0.245 No Hit 0.0% —
4284 VK055_2664 hypothetical protein AlphaFold + ColabFold – – 0.245 No Hit 0.0% —
4285 VK055_0423 ABC transporter family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.245 Hit 32.5% 4.13e-12
4286 VK055_4731 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.244 No Hit 0.0% —
4287 VK055_4084 hypothetical protein AlphaFold + ColabFold – – 0.244 No Hit 0.0% —
4288 VK055_3389 acetyltransferase family protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.244 No Hit 0.0% —
4289 VK055_2550 inosine-uridine preferring nucleoside hydrolase family protein AlphaFold + ColabFold
3.2.-.-
GO:0016799Catalysis of the hydrolysis of any N-glycosyl bond. GO:0016798Catalysis of the hydrolysis of any glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
0.244 No Hit 0.0% —
4290 VK055_1474 hypothetical protein ColabFold – – 0.244 No Hit 0.0% —
4291 VK055_5028 phosphoglucomutase/phosphomannomutase, C-terminal domain protein manB AlphaFold + ColabFold
5.4.2.8
GO:0071704OBSOLETE. The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. GO:0000287Binding to a magnesium (Mg) ion. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
0.243 No Hit 0.0% —
4292 VK055_4364 hypothetical protein AlphaFold + ColabFold – – 0.243 No Hit 0.0% —
4293 VK055_3842 ATP:dephospho-CoA triphosphoribosyl transferase family protein AlphaFold + ColabFold
2.4.2.52
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046917Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. +14 total
0.243 No Hit 0.0% —
4294 VK055_2940 hypothetical protein AlphaFold + ColabFold – – 0.243 No Hit 0.0% —
4295 VK055_2299 glycerol-3-phosphate responsive antiterminator family protein AlphaFold + ColabFold –
GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.243 No Hit 0.0% —
4296 VK055_1803 endonuclease VIII AlphaFold + ColabFold
3.2.2.- 4.2.99.18
GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. GO:0019104Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. GO:0003676Binding to a nucleic acid. +811 total
0.243 Hit 32.0% 2.45e-07
4297 VK055_4370 NLPA lipofamily protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.242 No Hit 0.0% —
4298 VK055_4143 glycine cleavage system H protein gcvH AlphaFold + ColabFold –
GO:0005960A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. GO:0019464The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.242 Hit 47.8% 7.78e-24
4299 VK055_2028 ABC transporter family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.242 Hit 36.1% 3.32e-19
4300 VK055_1904 inositol monophosphatase family protein AlphaFold + ColabFold
3.1.3.25
GO:0008934Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. GO:0046872Binding to a metal ion. GO:0006020The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. +25 total
0.242 Hit 35.0% 2.64e-06
Page of 204 · 5081 total proteins