Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4376 VK055_1808 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.089 0.794 No Hit 0.0% —
4377 VK055_1423 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.089 0.37 No Hit 0.0% —
4378 VK055_0652 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.089 No Hit 0.0% —
4379 VK055_3816 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.088 0.318 No Hit 0.0% —
4380 VK055_3260 superoxide dismutase (Mn) sodA AlphaFold DB model + ColabFold model
1.15.1.1
GO:0004784Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. GO:0006801The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. GO:0046872Binding to a metal ion. +25 total
Mapped 2 0.088 0.293 Hit 54.3% 2.07e-11
4381 VK055_2944 hypothetical protein ColabFold model – – No map 0.088 0.654 No Hit 0.0% —
4382 VK055_3115 transcription termination/antitermination factorNusG nusG AlphaFold DB model + ColabFold model –
GO:0032784Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. GO:0140673A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +47 total
No map 0.087 0.408 No Hit 0.0% —
4383 VK055_2027 fecCD transport family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.087 0.746 No Hit 0.0% —
4384 VK055_1752 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.087 No Hit 0.0% —
4385 VK055_4671 P-type conjugative transfer protein TrbL trbL ColabFold model –
GO:0030255The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system.
No map 0.086 0.917 No Hit 0.0% —
4386 VK055_4663 exodeoxyribonuclease VII, large subunit xseA AlphaFold DB model + ColabFold model
3.1.11.6
GO:0003676Binding to a nucleic acid. GO:0009318An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA. GO:0006308The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. +25 total
No map 0.086 0.29 No Hit 0.0% —
4387 VK055_1268 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.086 0.924 No Hit 0.0% —
4388 VK055_0981 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.086 0.04 No Hit 0.0% —
4389 VK055_0441 transposase family protein AlphaFold DB model + ColabFold model –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.086 No Hit 0.0% —
4390 VK055_4570 tRNA (guanine(37)-N(1))-methyltransferase trmD AlphaFold DB model + ColabFold model
2.1.1.228
GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0052906Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
Mapped 2 0.085 0.183 No Hit 0.0% —
4391 VK055_3032 replicative DNA helicase dnaB AlphaFold DB model + ColabFold model
5.6.2.3
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +710 total
No map 0.085 0.535 No Hit 0.0% —
4392 VK055_2491 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.085 0.674 No Hit 0.0% —
4393 VK055_2225 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.085 0.748 No Hit 0.0% —
4394 VK055_1792 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.085 No Hit 0.0% —
4395 VK055_1067 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.085 0.989 No Hit 0.0% —
4396 VK055_0871 bacterial regulatory helix-turn-helix, AraC family protein marA AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.085 0.132 No Hit 0.0% —
4397 VK055_0847 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.085 0.712 No Hit 0.0% —
4398 VK055_2726 transposase, Mutator family protein ColabFold model –
GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.084 0.286 No Hit 0.0% —
4399 VK055_2463 type II secretion system (T2SS), F family protein AlphaFold DB model + ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.084 0.892 No Hit 0.0% —
4400 VK055_5016 putative acid phosphatase Wzb wzb AlphaFold DB model + ColabFold model
3.1.3.48
GO:0006470The process of removing one or more phosphoric residues from a protein. GO:0004725Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Mapped 2 0.083 0.456 Hit 39.4% 3.82e-06
Page of 204 · 5081 total proteins