Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4426 VK055_4569 16S rRNA processing protein RimM rimM AlphaFold DB model + ColabFold model –
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0043022Binding to a ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +25 total
No map 0.078 0.016 No Hit 0.0% —
4427 VK055_3257 response regulator cpxR AlphaFold DB model + ColabFold model –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +58 total
No map 0.078 0.865 No Hit 0.0% —
4428 VK055_2913 fumarate reductase iron-sulfur protein frdB AlphaFold DB model + ColabFold model
1.3.5.1
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. +811 total
Mapped 1 0.078 0.508 Hit 37.2% 8.45e-11
4429 VK055_2110 maltose O-acetyltransferase maa AlphaFold DB model + ColabFold model –
GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
Mapped 1 0.078 0.123 No Hit 0.0% —
4430 VK055_1863 oligomerization domain protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043023Binding to a large ribosomal subunit. GO:0042256The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol. +25 total
No map 0.078 0.583 Hit 35.6% 3.22e-15
4431 VK055_1850 bacterial extracellular solute-binding, 3 familyprotein AlphaFold DB model + ColabFold model –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.078 0.912 No Hit 0.0% —
4432 VK055_1592 artI artI AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.078 0.07 No Hit 0.0% —
4433 VK055_1270 ahpC/TSA family protein AlphaFold DB model + ColabFold model –
GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0004602Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O.
No map 0.078 0.389 Hit 53.9% 2.04e-18
4434 VK055_0205 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.078 No Hit 0.0% —
4435 VK055_2403 lipo, PulS/OutS family protein AlphaFold DB model + ColabFold model –
GO:0006886The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
No map 0.077 0.497 No Hit 0.0% —
4436 VK055_2203 PTS system, Lactose/Cellobiose specific IIB subunit AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
No map 0.077 0.151 No Hit 0.0% —
4437 VK055_1711 ABC-2 type transporter family protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. +14 total
No map 0.076 0.787 No Hit 0.0% —
4438 VK055_4525 NADH-azoreductase, FMN-dependent Experimental + ColabFold model –
GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
No map 0.075 0.25 No Hit 0.0% —
4439 VK055_3486 pyrE pyrE AlphaFold DB model + ColabFold model
2.4.2.10
GO:0006221The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0004588Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
Chokepoint 1 0.075 0.116 Hit 31.2% 3.19e-08
4440 VK055_0899 bacterial regulatory, luxR family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.075 0.656 No Hit 0.0% —
4441 VK055_4472 D-arabinose 5-phosphate isomerase gutQ AlphaFold DB model + ColabFold model
5.3.1.13
GO:0097367Binding to a carbohydrate derivative. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +58 total
Mapped 1 0.074 0.346 No Hit 0.0% —
4442 VK055_3724 hypothetical protein ColabFold model – – No map N/A 0.074 No Hit 0.0% —
4443 VK055_3386 D-serine deaminase transcriptional activator dsdC AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.074 0.4 No Hit 0.0% —
4444 VK055_2927 type VII secretion system (T7SS), usher family protein AlphaFold DB model + ColabFold model –
GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515Binding to a protein. +25 total
No map 0.074 0.137 No Hit 0.0% —
4445 VK055_2297 putative zinc ribbon domain protein AlphaFold DB model + ColabFold model – – No map 0.074 0.509 No Hit 0.0% —
4446 VK055_1803 endonuclease VIII AlphaFold DB model + ColabFold model
3.2.2.- 4.2.99.18
GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. GO:0019104Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. GO:0003676Binding to a nucleic acid. +811 total
No map 0.074 0.243 Hit 32.0% 2.45e-07
4447 VK055_0369 glyoxalase/Bleomycin resistance /Dioxygenase superfamily protein AlphaFold DB model + ColabFold model –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
No map 0.074 0.036 No Hit 0.0% —
4448 VK055_4810 colicin V production family protein AlphaFold DB model + ColabFold model –
GO:0009403The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.073 0.608 No Hit 0.0% —
4449 VK055_3438 NUDIX domain protein AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006753The chemical reactions and pathways involving any phosphorylated nucleoside. +14 total
No map 0.073 0.172 No Hit 0.0% —
4450 VK055_3420 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.073 No Hit 0.0% —
Page of 204 · 5081 total proteins