Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4451 VK055_2749 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.073 0.466 No Hit 0.0% —
4452 VK055_1402 msyB family protein AlphaFold DB model + ColabFold model – – No map 0.073 0.195 No Hit 0.0% —
4453 VK055_1054 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.073 No Hit 0.0% —
4454 VK055_0204 periplasmic binding and sugar binding domain of LacI family protein AlphaFold DB model + ColabFold model –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.073 0.264 No Hit 0.0% —
4455 VK055_4707 transcriptional regulator, Spx/MgsR family protein AlphaFold DB model + ColabFold model – – No map 0.072 0.295 No Hit 0.0% —
4456 VK055_2781 helix-turn-helix domain, rpiR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. +25 total
No map 0.072 0.62 No Hit 0.0% —
4457 VK055_2770 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.072 0.881 No Hit 0.0% —
4458 VK055_5097 bacterial regulatory, luxR family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.071 0.804 No Hit 0.0% —
4459 VK055_2954 integral membrane, YjbE family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.071 0.518 No Hit 0.0% —
4460 VK055_2935 aspartate ammonia-lyase aspA AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006531The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. +25 total
Mapped 1 0.071 0.346 Hit 42.9% 2.13e-27
4461 VK055_2193 glyoxalase/Bleomycin resistance /Dioxygenase superfamily protein AlphaFold DB model + ColabFold model – – No map 0.071 0.078 No Hit 0.0% —
4462 VK055_0434 survival SurE family protein ColabFold model –
GO:0008252Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.071 0.313 No Hit 0.0% —
4463 VK055_4605 mucB/RseB family protein AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0045152Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator. GO:0032885Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.
No map 0.070 0.707 No Hit 0.0% —
4464 VK055_3542 conserved inner membrane protein yiaB AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
No map 0.070 0.435 No Hit 0.0% —
4465 VK055_3169 iron donor protein CyaY cyaY AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0008199Binding to a ferric iron ion, Fe(III). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map N/A 0.07 No Hit 0.0% —
4466 VK055_1856 filamentous hemagglutinin family N-terminal domain protein AlphaFold DB model + ColabFold model – – No map 0.070 0.294 No Hit 0.0% —
4467 VK055_0875 helix-turn-helix family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.070 0.685 No Hit 0.0% —
4468 VK055_3553 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.069 0.333 No Hit 0.0% —
4469 VK055_2762 prophage CP4-57 regulatory family protein AlphaFold DB model + ColabFold model – – No map N/A 0.069 No Hit 0.0% —
4470 VK055_2208 antibiotic biosynthesis monooxygenase family protein AlphaFold DB model + ColabFold model – – No map 0.069 0.721 No Hit 0.0% —
4471 VK055_1926 periplasmic binding family protein fepB AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1901678The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.069 0.382 No Hit 0.0% —
4472 VK055_1875 crcB-like family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0062054Enables the energy-independent facilitated diffusion of a fluoride ion through a transmembrane aqueous pore or channel. +25 total
No map 0.069 0.362 No Hit 0.0% —
4473 VK055_0194 sel1 repeat family protein ColabFold model –
GO:0005515Binding to a protein.
No map 0.069 0.598 No Hit 0.0% —
4474 VK055_5146 phage integrase family protein AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.068 0.495 No Hit 0.0% —
4475 VK055_4720 BMC domain protein AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.068 0.767 No Hit 0.0% —
Page of 204 · 5081 total proteins