Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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4645 / 5081 proteins Structure: AlphaFold

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Structure: AlphaFold DB model ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
426 VK055_5062 putative lipoate-protein ligase A AlphaFold DB model + ColabFold model –
GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
Chokepoint 10 0.933 No Hit 0.0% —
427 VK055_4591 H+ symporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.933 No Hit 0.0% —
428 VK055_3632 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.933 No Hit 0.0% —
429 VK055_2520 histidine kinase-, DNA gyrase B-, and HSP90-likeATPase family protein AlphaFold DB model + ColabFold model –
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. +14 total
No map 0.933 No Hit 0.0% —
430 VK055_1830 glutamine--tRNA ligase glnS AlphaFold DB model + ColabFold model
6.1.1.18
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0043039The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. GO:0004819Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). +811 total
Chokepoint 2 0.933 Hit 69.7% 2.15e-07
431 VK055_1536 ubiE/COQ5 methyltransferase family protein AlphaFold DB model + ColabFold model
2.1.1.-
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0097697Catalysis of the reaction: 5-carboxymethoxyuridine34 in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine34 in tRNA + S-adenosyl-L-homocysteine. The methylation occurs on the modified base. GO:0032259The process in which a methyl group is covalently attached to a molecule. +14 total
No map 0.933 No Hit 0.0% —
432 VK055_1465 succinate-semialdehyde dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0009013Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +36 total
No map 0.933 Hit 53.8% 2.35e-177
433 VK055_1413 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.933 No Hit 0.0% —
434 VK055_0443 alpha-ketoglutarate permease csbX AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.933 No Hit 0.0% —
435 VK055_5159 DNA adenine methylase family protein dam2 AlphaFold DB model + ColabFold model
2.1.1.72
GO:0003676Binding to a nucleic acid. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0009007Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. +69 total
Mapped 1 0.932 No Hit 0.0% —
436 VK055_5117 2,3-dihydroxybenzoate-AMP ligase ybtE AlphaFold DB model + ColabFold model –
GO:0016878Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
Mapped 1 0.932 Hit 36.1% 1.30e-17
437 VK055_4209 putative oxidoreductase, NAD(P)-binding putativeNAD(P)H-dependent xylose reductase AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.932 Hit 34.9% 4.23e-06
438 VK055_3555 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.932 Hit 24.3% 3.51e-11
439 VK055_1684 sulfatase family protein AlphaFold DB model + ColabFold model –
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.932 No Hit 0.0% —
440 VK055_0684 ahpC/TSA family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. +25 total
No map 0.932 Hit 31.1% 4.07e-20
441 VK055_0532 alpha/beta hydrolase fold family protein AlphaFold DB model + ColabFold model
3.1.1.-
GO:0004104Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.
No map 0.932 Hit 58.0% 2.28e-13
442 VK055_0072 holliday junction DNA helicase RuvB ruvB AlphaFold DB model + ColabFold model
3.6.4.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +69 total
No map 0.932 Hit 29.8% 2.70e-07
443 VK055_4580 SMP-30/Gluconolaconase/LRE-like region family protein AlphaFold DB model + ColabFold model –
GO:0005509Binding to a calcium ion (Ca2+). GO:0004341Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. GO:0019853The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
No map 0.931 Hit 30.4% 1.91e-31
444 VK055_3364 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.931 No Hit 0.0% —
445 VK055_1601 potI potI AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.931 No Hit 0.0% —
446 VK055_1138 L-Ala-D/L-Glu epimerase, a muconate lactonizing enzyme L-Ala-D/L-Glu epimerase AlphaFold DB model + ColabFold model
5.1.1.-
GO:0009063The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. GO:0016855Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. GO:0046872Binding to a metal ion.
No map 0.931 No Hit 0.0% —
447 VK055_0607 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.931 No Hit 0.0% —
448 VK055_4971 bacterially-derived sulfatase bds AlphaFold DB model + ColabFold model
3.1.6.21
GO:0018909The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants. GO:0046983The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. GO:0018741Catalysis of the reaction: a primary linear alkyl sulfate ester + H2O = a primary alcohol + H+ + sulfate. +14 total
No map 0.93 No Hit 0.0% —
449 VK055_4808 folyl-polyglutamate synthetase folC AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016881Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. +710 total
Chokepoint 1 0.93 Hit 37.4% 2.50e-29
450 VK055_1806 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.93 No Hit 0.0% —
Page of 186 · 4645 total proteins