Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5001 VK055_2589 bacterial virulence factor hemolysin family protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.004 0.598 No Hit 0.0% —
5002 VK055_2374 periplasmic chaperone hlpA AlphaFold DB model + ColabFold model –
GO:0051082Binding to an unfolded protein. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +14 total
No map 0.004 0.193 No Hit 0.0% —
5003 VK055_1781 peptidoglycan-associated lipoprotein pal AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
No map 0.004 0.206 No Hit 0.0% —
5004 VK055_1748 biofilm development YmgB/AriR family protein AlphaFold DB model + ColabFold model –
GO:0071468Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
No map N/A 0.004 No Hit 0.0% —
5005 VK055_1351 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.004 0.366 No Hit 0.0% —
5006 VK055_0641 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.004 0.216 No Hit 0.0% —
5007 VK055_0429 bacterial regulatory helix-turn-helix, lysR family protein ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.004 0.555 No Hit 0.0% —
5008 VK055_0158 putative nitrilotriacetate monooxygenase AlphaFold DB model + ColabFold model – – No map N/A 0.004 No Hit 0.0% —
5009 VK055_5158 bacterial regulatory, gntR family protein AlphaFold DB model + ColabFold model – – No map 0.003 0.468 No Hit 0.0% —
5010 VK055_4749 HPr ptsH AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
No map N/A 0.003 No Hit 0.0% —
5011 VK055_4660 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.003 0.371 No Hit 0.0% —
5012 VK055_4536 gram-negative pili assembly chaperone, C-terminal domain protein AlphaFold DB model + ColabFold model –
GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +14 total
No map 0.003 0.379 No Hit 0.0% —
5013 VK055_4464 hypothetical protein ColabFold model – – No map 0.003 0.421 No Hit 0.0% —
5014 VK055_4349 cysteine desulfurase, sulfur acceptor subunit CsdE csdE AlphaFold DB model + ColabFold model – – Chokepoint 19 0.003 0.598 No Hit 0.0% —
5015 VK055_4198 acid stress chaperone hdeB AlphaFold DB model + ColabFold model –
GO:0009268Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. GO:0051082Binding to an unfolded protein. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +14 total
No map 0.003 0.481 No Hit 0.0% —
5016 VK055_3279 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.003 No Hit 0.0% —
5017 VK055_3025 ssDNA-binding protein ssb Experimental + ColabFold model –
GO:0003697Binding to single-stranded DNA. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
No map N/A 0.003 Hit 38.9% 3.24e-16
5018 VK055_2929 hypothetical protein ColabFold model – – No map 0.003 0.799 No Hit 0.0% —
5019 VK055_2489 acetolactate synthase, small subunit ilvN AlphaFold DB model + ColabFold model
2.2.1.6
GO:1990610Binds to and modulates the activity of acetolactate synthase. GO:0009082The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
Chokepoint 2 0.003 0.712 No Hit 0.0% —
5020 VK055_2135 DNA base-flipping protein ybaZ ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
No map 0.003 0.683 Hit 44.7% 7.97e-06
5021 VK055_1499 hypothetical protein ColabFold model – – No map N/A 0.003 No Hit 0.0% —
5022 VK055_1166 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.003 No Hit 0.0% —
5023 VK055_0848 4-oxalocrotonate tautomerase family enzyme domain protein AlphaFold DB model + ColabFold model – – No map 0.003 0.155 No Hit 0.0% —
5024 VK055_4929 hypothetical protein ColabFold model – – No map N/A 0.002 No Hit 0.0% —
5025 VK055_4484 competence/damage-inducible CinA C-terminal domain protein AlphaFold DB model + ColabFold model – – No map 0.002 0.482 No Hit 0.0% —
Page of 204 · 5081 total proteins