Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4976 VK055_4305 BMC domain protein AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map N/A 0.005 No Hit 0.0% —
4977 VK055_4243 gram-negative pili assembly chaperone, C-terminal domain protein AlphaFold DB model + ColabFold model –
GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +14 total
No map 0.005 0.225 No Hit 0.0% —
4978 VK055_4137 protein that localizes to the cytokinetic ring ColabFold model – – No map N/A 0.005 No Hit 0.0% —
4979 VK055_3838 L-tartrate dehydratase, beta subunit ttdB AlphaFold DB model + ColabFold model
4.2.1.32
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0008730Catalysis of the reaction: L-tartrate = H2O + oxaloacetate.
Mapped 2 0.005 0.621 No Hit 0.0% —
4980 VK055_3678 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.005 0.352 No Hit 0.0% —
4981 VK055_3338 hypothetical protein ColabFold model – – No map 0.005 0.583 No Hit 0.0% —
4982 VK055_3337 ATP synthase F1, epsilon subunit atpC AlphaFold DB model + ColabFold model –
GO:0015986The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). GO:0046933Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in). GO:0045261OBSOLETE. The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. +36 total
No map 0.005 0.499 No Hit 0.0% —
4983 VK055_2454 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.005 No Hit 0.0% —
4984 VK055_2363 modulator of Rho-dependent transcription termination yaeO AlphaFold DB model + ColabFold model – – No map 0.005 0.048 No Hit 0.0% —
4985 VK055_2202 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 family protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
No map 0.005 0.589 No Hit 0.0% —
4986 VK055_2163 cytochrome o ubiquinol oxidase subunit IV cyoD AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009486Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]. GO:0015990The transport of protons against an electrochemical gradient, using energy from electron transport. +47 total
No map 0.005 0.922 No Hit 0.0% —
4987 VK055_1550 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.005 0.543 No Hit 0.0% —
4988 VK055_1493 hypothetical protein Experimental + AlphaFold DB model + ColabFold model – – No map 0.005 0.482 No Hit 0.0% —
4989 VK055_1488 sulfur relay, TusE/DsrC/DsvC family protein tusE AlphaFold DB model + ColabFold model
2.8.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +14 total
No map 0.005 0.752 No Hit 0.0% —
4990 VK055_0270 tonB protein energy transducer AlphaFold DB model + ColabFold model –
GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0031992The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell. +36 total
No map 0.005 0.038 No Hit 0.0% —
4991 VK055_0264 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.005 0.373 No Hit 0.0% —
4992 VK055_0226 dsrE/DsrF-like family protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map N/A 0.005 No Hit 0.0% —
4993 VK055_0179 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.005 0.355 No Hit 0.0% —
4994 VK055_0031 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.005 0.355 No Hit 0.0% —
4995 VK055_5160 endodeoxyribonuclease RusA family protein ColabFold model –
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0000287Binding to a magnesium (Mg) ion. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map N/A 0.004 No Hit 0.0% —
4996 VK055_5157 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.004 0.716 No Hit 0.0% —
4997 VK055_4502 emrA Membrane Fusion Protein AlphaFold DB model + ColabFold model –
GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.004 0.085 No Hit 0.0% —
4998 VK055_3915 GIY-YIG catalytic domain protein AlphaFold DB model + ColabFold model – – No map 0.004 0.234 No Hit 0.0% —
4999 VK055_3881 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.004 0.572 No Hit 0.0% —
5000 VK055_2695 hypothetical protein ColabFold model – – No map N/A 0.004 No Hit 0.0% —
Page of 204 · 5081 total proteins