Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4951 VK055_2711 merR regulatory family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.043 No Hit 0.0% —
4952 VK055_2017 short chain dehydrogenase family protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.043 Hit 40.9% 3.50e-11
4953 VK055_3791 dehydroshikimate reductase aroE AlphaFold + ColabFold –
GO:0004764Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0019632The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids.
0.042 No Hit 0.0% —
4954 VK055_4270 lysR transcriptional dual regulator AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
0.041 No Hit 0.0% —
4955 VK055_4242 fimbrial family protein AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.041 No Hit 0.0% —
4956 VK055_2816 PTS system, Lactose/Cellobiose specific IIB subunit AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.041 No Hit 0.0% —
4957 VK055_0981 hypothetical protein AlphaFold + ColabFold – – 0.04 No Hit 0.0% —
4958 VK055_0400 cytochrome c-type biogenesis protein CcmH ccmH AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
0.039 No Hit 0.0% —
4959 VK055_5089 type IV secretion system family protein AlphaFold + ColabFold – – 0.038 No Hit 0.0% —
4960 VK055_3325 asnC transcriptional repressor AsnC transcriptional dual regulator asnC AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.038 No Hit 0.0% —
4961 VK055_3163 DNA helicase II uvrD AlphaFold + ColabFold
5.6.2.4
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006268OBSOLETE. The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +1013 total
0.038 No Hit 0.0% —
4962 VK055_3090 heavy-metal resistance family protein AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.038 No Hit 0.0% —
4963 VK055_0709 ASCH domain protein ColabFold – – 0.038 No Hit 0.0% —
4964 VK055_0270 tonB protein energy transducer AlphaFold + ColabFold –
GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0031992The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell. +36 total
0.038 No Hit 0.0% —
4965 VK055_4233 fimbrial subunit type 1 fim2 AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.037 No Hit 0.0% —
4966 VK055_0646 hypothetical protein AlphaFold + ColabFold – – 0.037 No Hit 0.0% —
4967 VK055_0369 glyoxalase/Bleomycin resistance /Dioxygenase superfamily protein AlphaFold + ColabFold –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
0.036 No Hit 0.0% —
4968 VK055_2937 copper binding protein CutA cutA AlphaFold + ColabFold –
GO:0005507Binding to a copper (Cu) ion. GO:0010038Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.035 Hit 40.5% 7.82e-16
4969 VK055_4745 pyridoxal kinase AlphaFold + ColabFold
2.7.1.35
GO:0008478Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. GO:0009443Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.034 Hit 29.5% 4.41e-22
4970 VK055_1954 acetyltransferase family protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990189Catalysis of the reaction: acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-seryl-[protein]. +14 total
0.034 No Hit 0.0% —
4971 VK055_2287 minor fimbrial subunit, D-mannose specific adhesin fimH AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
0.033 No Hit 0.0% —
4972 VK055_4624 oxidoreductase NAD-binding domain protein AlphaFold + ColabFold
1.14.12.17
GO:0008941Catalysis of the reaction: 2 NO + 2 O2 + NAD(P)H + H+ = 2 nitrate + NAD(P)+. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +811 total
0.032 Hit 26.6% 8.27e-09
4973 VK055_0344 4-hydroxy-2-oxovalerate aldolase dmpG AlphaFold + ColabFold
4.1.3.39
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. GO:0008701Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. +58 total
0.032 Hit 26.5% 3.24e-07
4974 VK055_4229 fimbrial family protein AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.031 No Hit 0.0% —
4975 VK055_2782 hypothetical protein ColabFold – – 0.031 No Hit 0.0% —
Page of 204 · 5081 total proteins