Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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161 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
51 VK055_3982 glycerol dehydrase beta subunit gldB Experimental + ColabFold
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
0.803 No Hit 0.0% —
52 VK055_0681 alpha/beta hydrolase fold family protein Experimental + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.786 Hit 33.3% 1.66e-11
53 VK055_0901 competence/damage-inducible CinA C-terminal domain protein Experimental + ColabFold – – 0.781 No Hit 0.0% —
54 VK055_5043 histidinol-phosphate transaminase hisC Experimental + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004400Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +36 total
0.775 Hit 30.1% 2.73e-08
55 VK055_0207 peptidyl-tRNA hydrolase pth Experimental + ColabFold –
GO:0004045Catalysis of the reaction: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H+.
0.769 Hit 35.2% 2.63e-20
56 VK055_2484 essential cell division FtsI; penicillin-bindingprotein 3 ftsI2 Experimental + ColabFold
3.4.16.4
GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0008955Catalysis of the reaction: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+. +811 total
0.756 No Hit 0.0% —
57 VK055_4026 ADP-ribose pyrophosphatase nudF Experimental + ColabFold
3.6.1.13
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0046872Binding to a metal ion. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +69 total
0.75 No Hit 0.0% —
58 VK055_2836 putative thioredoxin-like protein Experimental + ColabFold –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
0.741 No Hit 0.0% —
59 VK055_0721 putative gamma-glutamyltransferase ywrD Experimental + ColabFold – – 0.734 Hit 30.5% 1.52e-07
60 VK055_2702 hypothetical protein Experimental + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.73 No Hit 0.0% —
61 VK055_1906 3-phytase phyK Experimental + ColabFold
3.1.3.8
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0016158Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate. GO:0046872Binding to a metal ion. +14 total
0.725 No Hit 0.0% —
62 VK055_5132 AMP nucleosidase amn Experimental + ColabFold
3.2.2.4
GO:0044209The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008714Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine. +25 total
0.712 No Hit 0.0% —
63 VK055_2824 2-dehydro-3-deoxyphosphogluconate aldolase Experimental + ColabFold – – 0.706 No Hit 0.0% —
64 VK055_4360 L-fuculose phosphate aldolase fucA Experimental + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0006004The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. GO:0008738Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate.
0.703 No Hit 0.0% —
65 VK055_3981 glycerol dehydratase large subunit dhaB Experimental + ColabFold
4.2.1.30
GO:0031419Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. +14 total
0.699 No Hit 0.0% —
66 VK055_1549 phosphoserine transaminase serC Experimental + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004648Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. GO:0006564The chemical reactions and pathways resulting in the formation of L-serine.
0.699 Hit 47.8% 1.14e-118
67 VK055_3983 glycerol dehydrase gamma subunit dhaB3 Experimental + ColabFold
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
0.695 No Hit 0.0% —
68 VK055_1952 betaine aldehyde dehydrogenase betB Experimental + ColabFold
1.2.1.8
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion. +25 total
0.692 Hit 53.1% 3.58e-08
69 VK055_5026 6-phosphogluconate dehydrogenase gnd Experimental + ColabFold
1.1.1.44
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004616Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. +25 total
0.687 Hit 58.2% 7.21e-76
70 VK055_0860 4-hydroxythreonine-4-phosphate dehydrogenase pdxA Experimental + ColabFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0046872Binding to a metal ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.682 No Hit 0.0% —
71 VK055_3380 6-phospho-alpha-glucosidase aglB Experimental + ColabFold
3.2.1.122
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +47 total
0.681 No Hit 0.0% —
72 VK055_4046 cystathionine beta-lyase metC2 Experimental + ColabFold
4.4.1.13
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019346The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. GO:0004121OBSOLETE. Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate. +69 total
0.673 Hit 31.9% 4.89e-47
73 VK055_4003 urease, alpha subunit ureC Experimental + ColabFold
3.5.1.5
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0009039Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +47 total
0.672 No Hit 0.0% —
74 VK055_3340 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase glmU Experimental + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0000902The developmental process in which the size or shape of a cell is generated and organized. GO:0003977Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. +58 total
0.669 No Hit 0.0% —
75 VK055_2523 exported protein required for envelope biosynthesis and integrity lptD Experimental + ColabFold –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0061024A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. +47 total
0.656 No Hit 0.0% —
Page of 7 · 161 total proteins