Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1776 VK055_1342 4-hydroxythreonine-4-phosphate dehydrogenase pdxA3 AlphaFold DB model + ColabFold model –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
Chokepoint 1 0.748 0.536 No Hit 0.0% —
1777 VK055_0883 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.748 0.834 No Hit 0.0% —
1778 VK055_3809 sodium/pantothenate symporter panF AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015233Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +69 total
No map 0.747 0.862 Hit 25.3% 4.81e-15
1779 VK055_2153 ATP-dependent Clp protease, ATP-binding subunit ClpX clpX AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008270Binding to a zinc ion (Zn). GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +811 total
No map 0.747 0.613 Hit 62.2% 3.12e-07
1780 VK055_2024 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.747 No Hit 0.0% —
1781 VK055_3410 PTS system, lactose/cellobiose IIC component family protein AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +14 total
No map 0.746 0.902 No Hit 0.0% —
1782 VK055_3181 wzyE family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.746 0.862 No Hit 0.0% —
1783 VK055_0384 CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI cas5e AlphaFold DB model + ColabFold model –
GO:0043571Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0051607Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
No map 0.746 0.536 No Hit 0.0% —
1784 VK055_4403 cysN cysN AlphaFold DB model + ColabFold model
2.7.7.4
GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0006790The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. +47 total
Chokepoint 2 0.745 0.257 Hit 37.1% 2.19e-28
1785 VK055_3477 phosphoenolpyruvate phosphomutase family protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0046872Binding to a metal ion.
No map 0.745 0.652 No Hit 0.0% —
1786 VK055_1245 putative thiosulfate sulfur transferase AlphaFold DB model + ColabFold model –
GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
Mapped 3 0.745 0.142 Hit 28.7% 1.14e-19
1787 VK055_5106 hypothetical protein ColabFold model – – No map N/A 0.744 No Hit 0.0% —
1788 VK055_3672 aspartate-semialdehyde dehydrogenase asd2 AlphaFold DB model + ColabFold model –
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0009086OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0009097OBSOLETE. The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. +811 total
Mapped 1 0.744 0.538 No Hit 0.0% —
1789 VK055_1148 phage shock protein C pspC AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.744 No Hit 0.0% —
1790 VK055_0851 acetyltransferase family protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.744 0.203 No Hit 0.0% —
1791 VK055_2542 citrate-sodium symporter citS Experimental + ColabFold model –
GO:0008514OBSOLETE. Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015711The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. +58 total
No map 0.743 0.987 No Hit 0.0% —
1792 VK055_1294 leuE leucine RhtB transporter AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.743 0.653 No Hit 0.0% —
1793 VK055_0427 amidohydrolase family protein AlphaFold DB model + ColabFold model –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0004131Catalysis of the reaction: cytosine + H2O = uracil + NH4+. GO:0035888Catalysis of the reaction: H+ + H2O + isoguanine = NH4+ + xanthine. +14 total
No map 0.743 0.891 No Hit 0.0% —
1794 VK055_4800 fabB fabB AlphaFold DB model + ColabFold model
2.3.1.41
GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +14 total
Chokepoint 10 0.742 0.588 Hit 34.8% 3.54e-58
1795 VK055_4059 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +25 total
No map 0.742 0.557 Hit 29.9% 7.70e-24
1796 VK055_3478 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0004521Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.
No map N/A 0.742 No Hit 0.0% —
1797 VK055_3339 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.742 No Hit 0.0% —
1798 VK055_1552 formate transporter FocA focA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015724The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +47 total
No map 0.742 0.876 No Hit 0.0% —
1799 VK055_0613 benzoate 1,2-dioxygenase electron transfer component benC AlphaFold DB model + ColabFold model –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
Chokepoint 3 0.742 0.852 Hit 24.5% 1.17e-07
1800 VK055_1191 telomere recombination family protein AlphaFold DB model + ColabFold model –
GO:0003725Binding to double-stranded RNA.
No map 0.741 0.531 Hit 26.8% 8.15e-06
Page of 204 · 5081 total proteins