Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1801 VK055_1690 amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.697 No Hit 0.0% —
1802 VK055_0888 lacY lactose MFS transporter lacY AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +47 total
0.697 No Hit 0.0% —
1803 VK055_0734 dihydrouridine synthase family protein AlphaFold + ColabFold
1.6.99.1
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.697 No Hit 0.0% —
1804 VK055_0119 putative cyclic-di-GMP phosphodiesterase AdrB AlphaFold + ColabFold
3.1.4.52
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
0.697 No Hit 0.0% —
1805 VK055_0114 hypothetical protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.697 No Hit 0.0% —
1806 VK055_4213 hypothetical protein AlphaFold + ColabFold – – 0.696 No Hit 0.0% —
1807 VK055_3763 hypothetical protein ColabFold – – 0.696 No Hit 0.0% —
1808 VK055_3611 universal stress B family protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.696 No Hit 0.0% —
1809 VK055_3116 preprotein translocase, SecE subunit secE AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009306The controlled release of proteins from a cell. GO:0008320Enables the transfer of a protein from one side of a membrane to the other. +58 total
0.696 No Hit 0.0% —
1810 VK055_1802 citrate (Si)-synthase gltA AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004108OBSOLETE. Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. +25 total
0.696 Hit 25.1% 4.23e-23
1811 VK055_1514 FMN reductase ssuE AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046306The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. GO:0008752Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates.
0.696 No Hit 0.0% —
1812 VK055_0347 putative thiosulfate sulfurtransferase AlphaFold + ColabFold –
GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+.
0.696 No Hit 0.0% —
1813 VK055_0081 glucose-6-phosphate dehydrogenase zwf AlphaFold + ColabFold
1.1.1.49
GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0004345Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +36 total
0.696 Hit 38.3% 1.11e-88
1814 VK055_4863 L-rhamnonate dehydratase rhmD AlphaFold + ColabFold
4.2.1.90
GO:0009063The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. GO:0050032Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.695 No Hit 0.0% —
1815 VK055_4220 putative outer membrane factor of efflux pump AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. +25 total
0.695 No Hit 0.0% —
1816 VK055_3983 glycerol dehydrase gamma subunit dhaB3 Experimental + ColabFold
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
0.695 No Hit 0.0% —
1817 VK055_3974 hypothetical protein AlphaFold + ColabFold – – 0.695 No Hit 0.0% —
1818 VK055_2657 4-hydroxyphenylacetate permease hpaX AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:1900754The directed movement of a 4-hydroxyphenylacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:1901241Enables the transfer of 4-hydroxyphenylacetate from one side of a membrane to the other. +14 total
0.695 No Hit 0.0% —
1819 VK055_1519 aminopeptidase N pepN AlphaFold + ColabFold
3.4.11.2
GO:0008270Binding to a zinc ion (Zn). GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +25 total
0.695 Hit 32.7% 3.52e-10
1820 VK055_1016 astC AlphaFold + ColabFold
2.6.1.11 2.6.1.17
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +811 total
0.695 Hit 34.3% 2.28e-06
1821 VK055_0306 major Facilitator Superfamily protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.695 No Hit 0.0% —
1822 VK055_4579 pheA pheA AlphaFold + ColabFold
4.2.1.51 5.4.99.5
GO:0004106Catalysis of the reaction: chorismate = prephenate. GO:0009094The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. GO:0046417The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid. +25 total
0.694 No Hit 0.0% —
1823 VK055_2932 hypothetical protein AlphaFold + ColabFold – – 0.694 No Hit 0.0% —
1824 VK055_2242 tauD AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. +25 total
0.694 No Hit 0.0% —
1825 VK055_1945 glycerol kinase glpK AlphaFold + ColabFold –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +47 total
0.694 Hit 34.7% 8.86e-85
Page of 204 · 5081 total proteins