Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 / 5081 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1976 VK055_5071 diguanylate cyclase domain protein AlphaFold DB model + ColabFold model
2.7.7.65
GO:0005515Binding to a protein. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+.
Chokepoint 1 0.699 0.608 No Hit 0.0% —
1977 VK055_2465 dephospho-CoA kinase coaE AlphaFold DB model + ColabFold model
2.7.1.24
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004140Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+. GO:0015937The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. +14 total
Mapped 1 0.699 0.48 Hit 45.9% 7.74e-25
1978 VK055_0961 3-oxoadipate enol-lactonase pcaD AlphaFold DB model + ColabFold model –
GO:0042952A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates. GO:0047570Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate.
Chokepoint 2 0.699 0.536 Hit 29.4% 4.84e-07
1979 VK055_0414 3-oxoacid CoA-transferase, B subunit AlphaFold DB model + ColabFold model –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
Chokepoint 2 0.699 0.415 Hit 49.8% 2.06e-69
1980 VK055_0111 essential cell division FtsI; penicillin-bindingprotein 3 ftsI AlphaFold DB model + ColabFold model
3.4.16.4
GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0008955Catalysis of the reaction: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+. +811 total
No map 0.699 0.202 No Hit 0.0% —
1981 VK055_4606 positive regulator of sigma(E), RseC/MucC familyprotein AlphaFold DB model + ColabFold model – – No map N/A 0.698 No Hit 0.0% —
1982 VK055_1228 lichenan-specific phosphotransferase enzyme IIB component licB AlphaFold DB model + ColabFold model
2.7.1.196
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map N/A 0.698 No Hit 0.0% —
1983 VK055_0969 indole-3-acetyl-aspartic acid hydrolase iaaH Experimental + ColabFold model –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.698 0.378 No Hit 0.0% —
1984 VK055_2419 type 4 prepilin-like proteins leader peptide-processing enzyme outO AlphaFold DB model + ColabFold model
2.1.1.- 3.4.23.43
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004190Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
No map 0.697 0.133 No Hit 0.0% —
1985 VK055_1738 formimidoylglutamase hutG AlphaFold DB model + ColabFold model
3.5.3.8
GO:0016813Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. GO:0050415Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide. GO:0019556OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide. +58 total
Chokepoint 1 0.697 0.413 Hit 23.1% 1.19e-08
1986 VK055_1667 molybdopterin biosynthesis AlphaFold DB model + ColabFold model
2.10.1.1
GO:0032324The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.697 0.787 Hit 43.4% 9.54e-32
1987 VK055_4191 urease accessory protein UreG ureG2 AlphaFold DB model + ColabFold model –
GO:0016151Binding to a nickel (Ni) cation. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. +36 total
No map 0.696 0.433 No Hit 0.0% —
1988 VK055_3763 hypothetical protein ColabFold model – – No map N/A 0.696 No Hit 0.0% —
1989 VK055_3116 preprotein translocase, SecE subunit secE AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009306The controlled release of proteins from a cell. GO:0008320Enables the transfer of a protein from one side of a membrane to the other. +58 total
No map N/A 0.696 No Hit 0.0% —
1990 VK055_2026 periplasmic binding family protein AlphaFold DB model + ColabFold model – – No map 0.696 0.457 No Hit 0.0% —
1991 VK055_1514 FMN reductase ssuE AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046306The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. GO:0008752Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates.
Mapped 3 N/A 0.696 No Hit 0.0% —
1992 VK055_3974 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.695 No Hit 0.0% —
1993 VK055_2789 putative cytoplasmic protein AlphaFold DB model + ColabFold model –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
No map 0.695 0.302 No Hit 0.0% —
1994 VK055_1495 DNA helicase IV helD AlphaFold DB model + ColabFold model
5.6.2.4
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
No map 0.695 0.491 No Hit 0.0% —
1995 VK055_1163 hutD family protein AlphaFold DB model + ColabFold model – – No map 0.695 0.184 No Hit 0.0% —
1996 VK055_4819 acetyltransferase family protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.694 0.343 No Hit 0.0% —
1997 VK055_3608 SAM-dependent methyltransferase family protein AlphaFold DB model + ColabFold model
2.1.1.242
GO:0031167The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. GO:0008990Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.694 0.447 No Hit 0.0% —
1998 VK055_0854 glutaminase A glsA AlphaFold DB model + ColabFold model
3.5.1.2
GO:0006541The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0006537OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. +14 total
Mapped 1 0.694 0.895 Hit 45.3% 2.34e-22
1999 VK055_1037 2Fe-2S iron-sulfur cluster binding domain protein AlphaFold DB model + ColabFold model –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +36 total
No map 0.693 0.352 Hit 26.7% 2.04e-09
2000 VK055_0938 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.693 0.455 No Hit 0.0% —
Page of 204 · 5081 total proteins