Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1976 VK055_4540 putative transport protein AlphaFold + ColabFold – – 0.665 No Hit 0.0% —
1977 VK055_3630 arnF arnF AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. +14 total
0.665 No Hit 0.0% —
1978 VK055_2718 hypothetical protein AlphaFold + ColabFold – – 0.665 No Hit 0.0% —
1979 VK055_2232 extensin-like family protein AlphaFold + ColabFold – – 0.665 No Hit 0.0% —
1980 VK055_2097 DNA polymerase III, subunit gamma and tau dnaX AlphaFold + ColabFold
2.7.7.7
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +58 total
0.665 Hit 23.8% 2.90e-15
1981 VK055_1582 doxX family protein ColabFold – – 0.665 No Hit 0.0% —
1982 VK055_1537 hypothetical protein AlphaFold + ColabFold – – 0.665 No Hit 0.0% —
1983 VK055_0577 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.665 No Hit 0.0% —
1984 VK055_3857 mannonate dehydratase uxuA AlphaFold + ColabFold
4.2.1.8
GO:0006064The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. GO:0008927Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. GO:0008198Binding to a ferrous iron ion, Fe(II). +25 total
0.664 No Hit 0.0% —
1985 VK055_2750 SIR2-like domain protein AlphaFold + ColabFold – – 0.664 No Hit 0.0% —
1986 VK055_2382 translation elongation factor Ts tsf AlphaFold + ColabFold –
GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0005515Binding to a protein. GO:0006414The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. +14 total
0.664 Hit 36.1% 3.51e-12
1987 VK055_1411 glyoxylate reductase / hydroxypyruvate reductase AlphaFold + ColabFold
1.1.1.79 1.1.1.81
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016618Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+. GO:0030267Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. +36 total
0.663 Hit 37.5% 2.30e-06
1988 VK055_1201 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
0.663 No Hit 0.0% —
1989 VK055_1193 anthranilate synthase component I trpE AlphaFold + ColabFold
4.1.3.27
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0004049Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. GO:0046872Binding to a metal ion. +14 total
0.663 No Hit 0.0% —
1990 VK055_1023 efflux transporter, RND family, MFP subunit AlphaFold + ColabFold –
GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.663 No Hit 0.0% —
1991 VK055_0852 diguanylate cyclase domain protein AlphaFold + ColabFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +25 total
0.663 No Hit 0.0% —
1992 VK055_0729 nitronate monooxygenase family protein AlphaFold + ColabFold –
GO:0018580Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite.
0.663 No Hit 0.0% —
1993 VK055_0433 2OG-Fe(II) oxygenase superfamily protein AlphaFold + ColabFold –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0046872Binding to a metal ion.
0.663 No Hit 0.0% —
1994 VK055_4302 GHMP kinase N terminal domain protein AlphaFold + ColabFold
2.7.1.177
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +14 total
0.662 No Hit 0.0% —
1995 VK055_3288 alpha/beta hydrolase fold-3 domain protein AlphaFold + ColabFold
3.1.1.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.662 Hit 37.6% 2.15e-14
1996 VK055_2189 transcriptional regulator NrdR nrdR AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.662 No Hit 0.0% —
1997 VK055_0763 resiniferatoxin-binding, phosphotriesterase-related protein AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0009056A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
0.662 Hit 35.5% 3.60e-35
1998 VK055_0569 ribonucleoside hydrolase 1 AlphaFold + ColabFold
3.2.-.-
GO:0045437Catalysis of the reaction: H2O + uridine = ribofuranose + uracil. GO:0016799Catalysis of the hydrolysis of any N-glycosyl bond. GO:0015949The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. +47 total
0.662 No Hit 0.0% —
1999 VK055_0458 glyoxalase family protein AlphaFold + ColabFold –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
0.662 No Hit 0.0% —
2000 VK055_0214 outer membrane lipoprotein LolB lolB AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.662 No Hit 0.0% —
Page of 204 · 5081 total proteins