Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1951 VK055_3971 dihydroxyacetone kinase, phosphotransfer subunit AlphaFold DB model + ColabFold model
2.7.1.121
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0019563The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. +36 total
No map 0.702 0.049 No Hit 0.0% —
1952 VK055_3467 fructose-1,6-bisphosphatase, class II glpX AlphaFold DB model + ColabFold model –
GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. GO:0042132Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. +36 total
Mapped 2 0.702 0.467 No Hit 0.0% —
1953 VK055_2409 type II secretion system protein E gspE AlphaFold DB model + ColabFold model –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +47 total
No map 0.702 0.522 No Hit 0.0% —
1954 VK055_0846 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.702 No Hit 0.0% —
1955 VK055_0779 carboxymuconolactone decarboxylase family protein ColabFold model –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
No map 0.702 0.49 No Hit 0.0% —
1956 VK055_0630 bacterial extracellular solute-binding, 5 Middlefamily protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
No map 0.702 0.998 No Hit 0.0% —
1957 VK055_0402 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.702 0.67 No Hit 0.0% —
1958 VK055_0061 copper homeostasis protein cutC AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005507Binding to a copper (Cu) ion.
No map 0.702 0.329 Hit 50.3% 5.62e-48
1959 VK055_4652 ndk ndk AlphaFold DB model + ColabFold model
2.7.4.6
GO:0004550Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. GO:0006241The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. GO:0006228The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. +47 total
Chokepoint 8 0.701 0.721 Hit 51.4% 1.87e-18
1960 VK055_3612 phosphate transporter family protein AlphaFold DB model + ColabFold model –
GO:0005315Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006817The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
No map 0.701 0.913 Hit 28.4% 3.63e-08
1961 VK055_3321 potassium uptake protein kup AlphaFold DB model + ColabFold model –
GO:0015079Enables the transfer of potassium ions (K+) from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0071805A process in which a potassium ion is transported from one side of a membrane to the other.
No map 0.701 0.644 No Hit 0.0% —
1962 VK055_3241 metL metL AlphaFold DB model + ColabFold model –
GO:0004072Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004412Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. +1013 total
No map 0.701 0.893 No Hit 0.0% —
1963 VK055_3153 sugar phosphatase Experimental + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.701 0.325 No Hit 0.0% —
1964 VK055_2469 preprotein translocase, SecA subunit secA AlphaFold DB model + ColabFold model
7.4.2.8
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0017038The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. +912 total
No map 0.701 0.259 No Hit 0.0% —
1965 VK055_1530 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +14 total
No map 0.701 0.381 No Hit 0.0% —
1966 VK055_0495 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.701 No Hit 0.0% —
1967 VK055_0379 CRISPR-associated helicase Cas3 cas3 AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +58 total
No map 0.701 0.687 No Hit 0.0% —
1968 VK055_4735 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.700 0.988 No Hit 0.0% —
1969 VK055_3465 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.700 0.995 No Hit 0.0% —
1970 VK055_3255 yiiP fieF AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other. +1013 total
No map 0.700 0.985 Hit 23.5% 2.86e-09
1971 VK055_2573 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.7 No Hit 0.0% —
1972 VK055_2342 endonuclease/Exonuclease/phosphatase family protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
No map 0.700 0.178 No Hit 0.0% —
1973 VK055_1345 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.700 0.917 No Hit 0.0% —
1974 VK055_0956 ygjE tartrate/succinate DASS transporter TtdT tartrate/succinate DASS transporter AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.700 0.807 Hit 22.5% 6.16e-07
1975 VK055_0259 oppB oppB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.700 0.642 No Hit 0.0% —
Page of 204 · 5081 total proteins