Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2301 VK055_2566 transaldolase tal3 AlphaFold DB model + ColabFold model
2.2.1.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004801Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
Mapped 1 0.612 0.128 Hit 60.4% 2.48e-134
2302 VK055_1914 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.612 0.767 Hit 37.1% 8.67e-10
2303 VK055_1567 thiol reductant ABC exporter, CydD subunit cydD AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042883The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +58 total
No map 0.612 0.682 Hit 42.4% 3.80e-10
2304 VK055_1304 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.612 No Hit 0.0% —
2305 VK055_0543 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.612 0.518 No Hit 0.0% —
2306 VK055_2398 periplasmic binding family protein AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1901678The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.611 0.546 No Hit 0.0% —
2307 VK055_0986 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.611 No Hit 0.0% —
2308 VK055_0878 urea ABC transporter, permease protein UrtC urtC AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +25 total
No map 0.611 0.905 No Hit 0.0% —
2309 VK055_4897 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.61 No Hit 0.0% —
2310 VK055_4283 integral membrane TerC family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.610 0.89 No Hit 0.0% —
2311 VK055_3960 lsrR transcriptional repressor AlphaFold DB model + ColabFold model –
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
No map 0.610 0.512 No Hit 0.0% —
2312 VK055_3481 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.61 No Hit 0.0% —
2313 VK055_5062 putative lipoate-protein ligase A AlphaFold DB model + ColabFold model –
GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
Chokepoint 10 0.608 0.933 No Hit 0.0% —
2314 VK055_4676 SEC-C motif family protein ColabFold model – – No map 0.608 0.87 No Hit 0.0% —
2315 VK055_2539 citrate (pro-3S)-lyase, beta subunit citE AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009346Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity. This enzyme has only been found in bacteria. GO:0006084The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. +25 total
Chokepoint 3 0.608 0.506 Hit 31.3% 1.87e-14
2316 VK055_3821 septum formation protein Maf maf2 AlphaFold DB model + ColabFold model
3.6.1.9
GO:0047429Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0036218Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate. +25 total
No map 0.607 0.19 Hit 43.2% 8.03e-33
2317 VK055_2641 2-oxo-3-deoxygalactonate kinase dgoK2 AlphaFold DB model + ColabFold model –
GO:0008671Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+. GO:0034194The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.
Chokepoint 1 0.607 0.286 No Hit 0.0% —
2318 VK055_0178 RNA pseudouridylate synthase family protein AlphaFold DB model + ColabFold model
5.4.99.28
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. +36 total
No map 0.607 0.598 Hit 45.9% 8.98e-10
2319 VK055_3137 NAD(P)H-flavin reductase fre AlphaFold DB model + ColabFold model
1.5.1.41
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0052875Catalysis of the reaction: reduced riboflavin + NAD(P)+ = riboflavin + NAD(P)H + 2 H+. This reaction can utilize NADH and NADPH. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Mapped 2 0.606 0.65 Hit 23.4% 7.88e-06
2320 VK055_2925 fimbrial family protein AlphaFold DB model + ColabFold model –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
No map 0.606 0.684 No Hit 0.0% —
2321 VK055_2888 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.606 No Hit 0.0% —
2322 VK055_5148 hypothetical protein ColabFold model – – No map N/A 0.605 No Hit 0.0% —
2323 VK055_3942 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0043022Binding to a ribosome. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map N/A 0.605 No Hit 0.0% —
2324 VK055_3074 sodium-dependent inorganic phosphate (Pi) transporter family protein pnaS AlphaFold DB model + ColabFold model –
GO:0044341The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005436Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).
No map 0.605 0.98 No Hit 0.0% —
2325 VK055_2824 2-dehydro-3-deoxyphosphogluconate aldolase Experimental + ColabFold model – – Chokepoint 2 0.605 0.706 No Hit 0.0% —
Page of 204 · 5081 total proteins