Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2451 VK055_0769 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.567 No Hit 0.0% —
2452 VK055_4846 NADH:ubiquinone oxidoreductase, membrane subunitK nuoK AlphaFold DB model + ColabFold model
7.1.1.-
GO:0042773The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0030964An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. +36 total
Mapped 3 N/A 0.566 No Hit 0.0% —
2453 VK055_3743 sensory box protein AlphaFold DB model + ColabFold model – – No map 0.566 0.456 No Hit 0.0% —
2454 VK055_3704 peptidoglycan synthetase penicillin-binding protein 1A AlphaFold DB model + ColabFold model
2.4.99.28 3.4.16.4
GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
No map 0.566 0.568 No Hit 0.0% —
2455 VK055_3094 endonuclease V nfi AlphaFold DB model + ColabFold model
3.1.21.7
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
No map 0.566 0.701 Hit 48.6% 7.59e-18
2456 VK055_4727 ethanolamine ammonia-lyase, putative regulatory subunit AlphaFold DB model + ColabFold model
4.3.1.7
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0008851Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
Mapped 1 0.565 0.293 No Hit 0.0% —
2457 VK055_4284 DNA mismatch repair endonuclease MutH mutH AlphaFold DB model + ColabFold model –
GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0006304The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
No map 0.565 0.313 No Hit 0.0% —
2458 VK055_3485 ribonuclease PH rph AlphaFold DB model + ColabFold model
2.7.7.56
GO:0009022Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0000049Binding to a transfer RNA. +36 total
No map 0.565 0.499 Hit 38.0% 6.71e-06
2459 VK055_2585 heme ABC exporter, ATP-binding protein CcmA ccmA7 AlphaFold DB model + ColabFold model
3.6.1.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0045900Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. +58 total
No map 0.565 0.5 Hit 35.0% 1.64e-13
2460 VK055_1658 aldose sugar dehydrogenase yliI AlphaFold DB model + ColabFold model – – Mapped 3 0.565 0.484 Hit 28.5% 1.37e-13
2461 VK055_1622 hypothetical protein ColabFold model – – No map N/A 0.565 No Hit 0.0% —
2462 VK055_1546 ribosomal protein S1 rpsA AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0003676Binding to a nucleic acid. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
No map N/A 0.565 Hit 46.0% 7.27e-08
2463 VK055_1043 primary amine oxidase maoA AlphaFold DB model + ColabFold model
1.4.3.-
GO:0005507Binding to a copper (Cu) ion. GO:0008131Catalysis of the reaction: a primary methyl amine + H2O + O2 = an aldehyde + H2O2 + NH4+. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +36 total
Chokepoint 8 0.565 0.985 Hit 28.1% 3.19e-32
2464 VK055_4344 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT AlphaFold DB model + ColabFold model
2.4.2.21
GO:0008939Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
Chokepoint 9 0.564 0.639 No Hit 0.0% —
2465 VK055_0711 putative membrane domain protein AlphaFold DB model + ColabFold model – – No map N/A 0.564 No Hit 0.0% —
2466 VK055_4644 ferredoxin, 2Fe-2S type, ISC system fdx AlphaFold DB model + ColabFold model –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. +36 total
No map N/A 0.563 Hit 41.1% 5.00e-14
2467 VK055_4332 precorrin-4 C11-methyltransferase cobM AlphaFold DB model + ColabFold model –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0046026Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5. +14 total
Chokepoint 1 0.563 0.655 No Hit 0.0% —
2468 VK055_4241 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.563 No Hit 0.0% —
2469 VK055_3985 glpF - glycerol MIP channel glpF AlphaFold DB model + ColabFold model –
GO:0015267Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.563 0.969 Hit 43.7% 7.28e-45
2470 VK055_0474 putative lysine decarboxylase family protein AlphaFold DB model + ColabFold model
3.2.2.n1
GO:0009691The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.563 0.365 No Hit 0.0% —
2471 VK055_0076 putative peptidase AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +14 total
No map 0.563 0.29 No Hit 0.0% —
2472 VK055_4839 nuoC AlphaFold DB model + ColabFold model
7.1.1.-
GO:0050136Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). +58 total
No map 0.562 0.836 Hit 44.5% 1.93e-32
2473 VK055_1698 glycosyl transferase family, helical bundle domain protein AlphaFold DB model + ColabFold model –
GO:0004048Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate. GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.562 0.584 No Hit 0.0% —
2474 VK055_1445 pyrimidine utilization transport protein G rutG AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015218Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. GO:0006864The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. +47 total
No map 0.562 0.98 Hit 32.4% 4.20e-11
2475 VK055_2598 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map N/A 0.561 No Hit 0.0% —
Page of 204 · 5081 total proteins