Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2401 VK055_1129 hypothetical protein ColabFold – – 0.591 No Hit 0.0% —
2402 VK055_1120 hypothetical protein AlphaFold + ColabFold – – 0.591 No Hit 0.0% —
2403 VK055_0980 putative aTP synthase subunit epsilon AlphaFold + ColabFold – – 0.591 No Hit 0.0% —
2404 VK055_3399 hypothetical protein AlphaFold + ColabFold – – 0.59 No Hit 0.0% —
2405 VK055_3220 glutamate racemase murI AlphaFold + ColabFold
5.1.1.3
GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0008881Catalysis of the reaction: L-glutamate = D-glutamate. GO:0036361OBSOLETE. Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. +47 total
0.59 No Hit 0.0% —
2406 VK055_2846 AIG2-like family protein AlphaFold + ColabFold –
GO:0061929Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.59 No Hit 0.0% —
2407 VK055_4237 phage integrase family protein AlphaFold + ColabFold –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
0.589 No Hit 0.0% —
2408 VK055_4079 nupG nucleoside MFS transporter nupG AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005337Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +69 total
0.589 No Hit 0.0% —
2409 VK055_2775 inosose dehydratase iolE AlphaFold + ColabFold
4.2.1.44
GO:0030145Binding to a manganese ion (Mn). GO:0050114Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O. GO:0019310The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. +14 total
0.589 No Hit 0.0% —
2410 VK055_2202 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 family protein AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
0.589 No Hit 0.0% —
2411 VK055_2102 hypothetical protein AlphaFold + ColabFold –
GO:1990238Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
0.589 No Hit 0.0% —
2412 VK055_0197 hypothetical protein AlphaFold + ColabFold – – 0.589 No Hit 0.0% —
2413 VK055_4800 fabB fabB AlphaFold + ColabFold
2.3.1.41
GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +14 total
0.588 Hit 34.8% 3.54e-58
2414 VK055_4756 hypothetical protein AlphaFold + ColabFold – – 0.588 No Hit 0.0% —
2415 VK055_3366 bacterial regulatory, gntR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.588 No Hit 0.0% —
2416 VK055_2820 addiction module toxin, RelE/StbE family protein AlphaFold + ColabFold – – 0.588 No Hit 0.0% —
2417 VK055_4939 cytidine deaminase cdd Experimental + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004126Catalysis of the reaction: cytidine + H+ + H2O = uridine + NH4 and deoxycytidine + H+ + H2O = deoxyuridine + NH4+. GO:0008270Binding to a zinc ion (Zn). +25 total
0.587 Hit 33.0% 8.75e-10
2418 VK055_4368 ABC transporter family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.587 Hit 38.2% 3.26e-29
2419 VK055_3266 rhamnulose-1-phosphate aldolase rhaD AlphaFold + ColabFold
4.1.2.19
GO:0008994Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. GO:0019301The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.587 No Hit 0.0% —
2420 VK055_1982 hypothetical protein AlphaFold + ColabFold – – 0.587 No Hit 0.0% —
2421 VK055_0042 putative ferritin-1 AlphaFold + ColabFold
1.16.3.2
GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008199Binding to a ferric iron ion, Fe(III). GO:0006879A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. +47 total
0.587 No Hit 0.0% —
2422 VK055_5083 P-type DNA transfer ATPase VirB11 virB11 AlphaFold + ColabFold –
GO:0044097The controlled release of proteins or DNA by a cell, via the type IV secretion system. GO:0043684A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.586 No Hit 0.0% —
2423 VK055_4529 hypothetical protein AlphaFold + ColabFold – – 0.586 No Hit 0.0% —
2424 VK055_4032 flavodoxin-like fold family protein AlphaFold + ColabFold
1.6.5.10
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008753Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol.
0.586 No Hit 0.0% —
2425 VK055_2385 protein-P-II uridylyltransferase glnD AlphaFold + ColabFold –
GO:0008773Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. +36 total
0.586 No Hit 0.0% —
Page of 204 · 5081 total proteins