Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2401 VK055_4577 3-deoxy-7-phosphoheptulonate synthase AlphaFold DB model + ColabFold model
2.5.1.54
GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). GO:0003849Catalysis of the reaction: D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +47 total
Chokepoint 1 0.583 0.669 No Hit 0.0% —
2402 VK055_2948 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA pgaA AlphaFold DB model + ColabFold model –
GO:1901515Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other. GO:0005515Binding to a protein.
No map 0.583 0.239 No Hit 0.0% —
2403 VK055_2922 hlyD secretion family protein AlphaFold DB model + ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map N/A 0.583 No Hit 0.0% —
2404 VK055_2514 L-ribulose-5-phosphate 4-epimerase araD AlphaFold DB model + ColabFold model
5.1.3.4
GO:0008270Binding to a zinc ion (Zn). GO:0008742Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate. GO:0019569The chemical reactions and pathways resulting in the breakdown of L-arabinose into D-xylulose 5-phosphate. +36 total
Mapped 1 0.583 0.405 No Hit 0.0% —
2405 VK055_2460 nicotinate-nucleotide diphosphorylase nadC AlphaFold DB model + ColabFold model
2.4.2.19
GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. GO:0004514Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate. +25 total
Chokepoint 1 0.583 0.283 Hit 38.6% 1.05e-13
2406 VK055_0383 CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI cas7 Experimental + ColabFold model – – No map 0.583 0.855 No Hit 0.0% —
2407 VK055_4616 haloacid dehalogenase-like hydrolase family protein AlphaFold DB model + ColabFold model
3.1.3.27
GO:0046872Binding to a metal ion. GO:0008962Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.
No map 0.582 0.665 No Hit 0.0% —
2408 VK055_2263 putative receptor AlphaFold DB model + ColabFold model – – No map 0.582 0.098 No Hit 0.0% —
2409 VK055_1751 blue light-responsive regulator of YcgE ycgF2 AlphaFold DB model + ColabFold model –
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0009882The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
No map 0.582 0.806 No Hit 0.0% —
2410 VK055_1001 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.582 0.542 No Hit 0.0% —
2411 VK055_0034 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase pgsA AlphaFold DB model + ColabFold model
2.7.8.5
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. GO:0008444Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+. +36 total
Mapped 1 0.582 0.599 Hit 41.3% 1.83e-08
2412 VK055_4264 maltoporin periplasmic N-terminal extension family protein AlphaFold DB model + ColabFold model – – No map 0.581 0.968 No Hit 0.0% —
2413 VK055_2685 branched-chain amino acid transport system / permease component family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.581 0.882 No Hit 0.0% —
2414 VK055_2492 hypothetical protein ColabFold model – – No map N/A 0.581 No Hit 0.0% —
2415 VK055_1418 hypothetical protein ColabFold model – – No map N/A 0.581 No Hit 0.0% —
2416 VK055_0818 melibiase family protein AlphaFold DB model + ColabFold model – – No map 0.581 0.251 No Hit 0.0% —
2417 VK055_3730 argD AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +25 total
No map 0.580 0.552 Hit 38.6% 1.06e-07
2418 VK055_2867 ribosomal protein S18 rpsR AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +25 total
No map N/A 0.58 No Hit 0.0% —
2419 VK055_2321 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.58 No Hit 0.0% —
2420 VK055_2097 DNA polymerase III, subunit gamma and tau dnaX AlphaFold DB model + ColabFold model
2.7.7.7
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. +58 total
No map 0.580 0.665 Hit 23.8% 2.90e-15
2421 VK055_4564 phage lambda replication host DNA synthesis heatshock protein repair grpE AlphaFold DB model + ColabFold model –
GO:0000774Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0051087Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. +36 total
No map N/A 0.579 Hit 35.8% 3.15e-16
2422 VK055_4031 quinol monooxygenase monomer ygiN AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.579 0.728 No Hit 0.0% —
2423 VK055_3058 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
No map N/A 0.579 Hit 43.2% 1.75e-14
2424 VK055_2123 cyclodextrin-binding protein cycB AlphaFold DB model + ColabFold model –
GO:0015144Enables the transfer of carbohydrate from one side of a membrane to the other. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0055052A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP. +47 total
No map 0.579 0.892 No Hit 0.0% —
2425 VK055_1644 hypothetical protein ColabFold model – – No map N/A 0.579 No Hit 0.0% —
Page of 204 · 5081 total proteins