Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_0001 lambda phage tail tape-measure family protein ColabFold model – – No map 0.6 No Hit 0.0% —
2 VK055_0002 putative kinase domain protein ColabFold model – – No map 0.911 No Hit 0.0% —
3 VK055_0003 hypothetical protein ColabFold model – – No map No pocket No Hit 0.0% —
4 VK055_0004 putative kinase domain protein ColabFold model – – No map 0.495 No Hit 0.0% —
5 VK055_0005 phage tail family protein ColabFold model – – No map 0.637 No Hit 0.0% —
6 VK055_0006 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.204 No Hit 0.0% —
7 VK055_0007 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.631 No Hit 0.0% —
8 VK055_0008 GDSL-like Lipase/Acylhydrolase family protein AlphaFold DB model + ColabFold model –
GO:0016788Catalysis of the hydrolysis of any ester bond.
No map 0.299 No Hit 0.0% —
9 VK055_0009 resolvase, N terminal domain protein AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0000150Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.088 No Hit 0.0% —
10 VK055_0010 helix-turn-helix domain of resolvase family protein ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0000150Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.206 No Hit 0.0% —
11 VK055_0011 hypothetical protein ColabFold model – – No map 0.533 No Hit 0.0% —
12 VK055_0012 hypothetical protein ColabFold model – – No map 0.48 No Hit 0.0% —
13 VK055_0013 outer membrane protein C ompC AlphaFold DB model + ColabFold model –
GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +25 total
No map 0.99 No Hit 0.0% —
14 VK055_0014 putative outer membrane protein N AlphaFold DB model + ColabFold model –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
No map 0.388 No Hit 0.0% —
15 VK055_0015 HD domain protein AlphaFold DB model + ColabFold model – – No map 0.152 No Hit 0.0% —
16 VK055_0016 cytosine-specific methyltransferase dcm AlphaFold DB model + ColabFold model
2.1.1.37
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003886Catalysis of the reaction: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
Mapped 1 0.205 Hit 26.0% 1.71e-06
17 VK055_0017 eamA-like transporter family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.988 No Hit 0.0% —
18 VK055_0018 DNA mismatch endonuclease of the very short patch (VSP) mismatch repair pathway AlphaFold DB model + ColabFold model
3.1.-.-
GO:0006298A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.292 No Hit 0.0% —
19 VK055_0019 conserved inner membrane protein yedI AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.943 No Hit 0.0% —
20 VK055_0020 diguanylate cyclase domain protein AlphaFold DB model + ColabFold model
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +47 total
Chokepoint 1 0.595 No Hit 0.0% —
21 VK055_0021 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.552 No Hit 0.0% —
22 VK055_0022 dextransucrase DSRB family protein AlphaFold DB model + ColabFold model – – No map 0.122 No Hit 0.0% —
23 VK055_0023 positive DNA-binding transcriptional regulator of capsular polysaccharide synthesis, activates its own expression rcsA AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.263 No Hit 0.0% —
24 VK055_0024 yedD-like family protein Experimental + ColabFold model – – No map 0.382 No Hit 0.0% —
25 VK055_0025 amylase amyK38 AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005509Binding to a calcium ion (Ca2+). +25 total
No map 0.712 No Hit 0.0% —
Page of 204 · 5081 total proteins